Protein Alignment VGAT and SLC38A4

DIOPT Version :9

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_001137296.1
• Gene: SLC38A4 / 55089
• HGNCID: 14679
• Length: 547
• Species: Homo sapiens
• Alignment Length: 601
• Identity: 117/601 - (19%)
• Similarity: 212/601 - (35%)
• Gaps: 217/601 - (36%)

  Fly    82 TNDGEGGGD---GDGEYRNEYQSTSFNEYDGRYQQ--TDGFRQGSIASEGSSFVCEGEGGGGCKI 141
            ::.||...|   |.|.......|:.|...|...|:  |:||.                  |..|:
Human    17 SSSGESAPDSYIGIGNSEKAAMSSQFANEDTESQKFLTNGFL------------------GKKKL 63

  Fly   142 DEF------------QAAWNVTNAIQGMFIVSLPFAVLHGG-YWAIVAMVGIAHICCYTGKVLVQ 193
            .::            .:::|::|||.|..|:.|.:|:.:.| ...|:.::.:|.:..|:..:|::
Human    64 ADYADEHHPGTTSFGMSSFNLSNAIMGSGILGLSYAMANTGIILFIIMLLAVAILSLYSVHLLLK 128

  Fly   194 CLYEPDPATGQMVRVRDSYVAIAKVCFG--PKLGARAVSIAQLIELLMTCILYVVV--------- 247
            ...|    .|.::     |..:.:..||  .|:|| .|||.......|:..|:::.
Human   129 TAKE----GGSLI-----YEKLGEKAFGWPGKIGA-FVSITMQNIGAMSSYLFIIKYELPEVIRA 183

  Fly   248 -------CGD-LLAGTYPQGSFDSRSWMLFVGI-FLLPMGFLKSLKMVS-TLSFWCTMSHIVINA 302
                   .|: .|.|.|         .::||.: .:||:..||:|..:. |..|..|.....::.
Human   184 FMGLEENTGEWYLNGNY---------LIIFVSVGIILPLSLLKNLGYLGYTSGFSLTCMVFFVSV 239

  Fly   303 VILGYCLLQIGDWGWSKVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSH 367
            ||            :.|.:....:.....|:|.:.|:.|..:.:..|..|. :.|..|:|:|::|
Human   240 VI------------YKKFQIPCPLPVLDHSVGNLSFNNTLPMHVVMLPNNS-ESSDVNFMMDYTH 291

  Fly   368 ----------IAAAVFKAGFGYIC---------FLTFQNDTQQVITNNLHSQGFKGMVNFFLVIK 413
                      ...::..:|..|..         :..|.:.|...|.               :::.
Human   292 RNPAGLDENQAKGSLHDSGVEYEAHSDDKCEPKYFVFNSRTAYAIP---------------ILVF 341

  Fly   414 ALLSYP--LPYYAACELLERNFFRGPPKTKFPTIWNLD--------------------GEL---- 452
            |.:.:|  ||.|:  ||.:|:      :.|..|:.|:.                    ||:
Human   342 AFVCHPEVLPIYS--ELKDRS------RRKMQTVSNISITGMLVMYLLAALFGYLTFYGEVEDEL 398

  Fly   453 -----KVWGLGF-----RVGVIVSTIL-------------------------------------- 469
                 ||:.|..     |:.|:|:..|
Human   399 LHAYSKVYTLDIPLLMVRLAVLVAVTLTVPIVLFPIRTSVITLLFPKRPFSWIRHFLIAAVLIAL 463

  Fly   470 ---MAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKI---KGHLLDQKEIAKDYLIIGLGVLFG 528
               :.|.:|....:.||||:.:.|||.||.|..|::|:   :.....||..|..:|::|:..:.|
Human   464 NNVLVILVPTIKYIFGFIGASSATMLIFILPAVFYLKLVKKETFRSPQKVGALIFLVVGIFFMIG 528

  Fly   529 VIG------IYDSGNA 538
            .:.      |||..|:
Human   529 SMALIIIDWIYDPPNS 544

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	99/527 (19%)
SLC38A4	NP_001137296.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		3/12 (25%)
		SdaC	71..534	CDD:223884	99/517 (19%)
		SLC5-6-like_sbd	73..535	CDD:294310	99/516 (19%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810