Protein Alignment VGAT and SLC38A2

DIOPT Version :10

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_061849.2
• Gene: SLC38A2 / 54407
• HGNCID: 13448
• Length: 506
• Species: Homo sapiens
• Alignment Length: 537
• Identity: 110/537 - (20%)
• Similarity: 191/537 - (35%)
• Gaps: 159/537 - (29%)

  Fly   101 STSFNEYDGRYQQTDGF------RQGSIAS-------EGSSFVCEGEGGGGCKIDEF-------- 144
            |.|.:|....|.....|      :|.::.|       |..:|:.|...|......||
Human    10 SISPDEDSSSYSSNSDFNYSYPTKQAALKSHYADVDPENQNFLLESNLGKKKYETEFHPGTTSFG 74

  Fly   145 QAAWNVTNAIQGMFIVSLPFAVLHGG---YWAIVAMVGI-----AHICCYTGKVLVQCLYE---- 197
            .:.:|::|||.|..|:.|.:|:.:.|   :..::..|.|     .|:...|.......|||
Human    75 MSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSLYSVHLLLKTANEGGSLLYEQLGY 139

  Fly   198 -----------PDPATGQMVRVRDSYVAIAKVCFGPKLGARAVSIAQLIELL-----MTCILYVV 246
                       ....|.|.:....||:.|.|           ..:..:|:.|     .|.:.|
Human   140 KAFGLVGKLAASGSITMQNIGAMSSYLFIVK-----------YELPLVIQALTNIEDKTGLWY-- 191

  Fly   247 VCGDLLAGTYPQGSFDSRSWMLFVG-IFLLPMGFLKSLKMV---STLSFWCTM------------ 295
                 |.|.|         .:|.|. :.:||:...::|..:   |.||..|.:
Human   192 -----LNGNY---------LVLLVSLVVILPLSLFRNLGYLGYTSGLSLLCMVFFLIVVICKKFQ 242

  Fly   296 ------SHIVINAVILGYCLLQ-----------IGDWGWSKVRFSIDMENFPISLGVIVFSYTSQ 343
                  :.::||..| ...|.|           :.:....:..:.|.......::.:::||:...
Human   243 VPCPVEAALIINETI-NTTLTQPTALVPALSHNVTENDSCRPHYFIFNSQTVYAVPILIFSFVCH 306

  Fly   344 -IFLPTLEGNMIDRSKFNWMLDWSHIA-AAVF-----KAGFGYICFLTFQNDTQQVITNNLHS-Q 400
             ..||..| .:.|||: ..|::.|.|: .|:|     .|.|||:.|.      :.|.:..||: .
Human   307 PAVLPIYE-ELKDRSR-RRMMNVSKISFFAMFLMYLLAALFGYLTFY------EHVESELLHTYS 363

  Fly   401 GFKG------MVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLDGELKVWGLG- 458
            ...|      :|...:::...|:.|:..:             |.::....:.....:...|...
Human   364 SILGTDILLLIVRLAVLMAVTLTVPVVIF-------------PIRSSVTHLLCASKDFSWWRHSL 415

  Fly   459 FRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKIKGHLLDQKEIAKD------ 517
            ..|.::..|.|:.||:|....:.||||:...:||.||.|..|:||     |.:||..|.
Human   416 ITVSILAFTNLLVIFVPTIRDIFGFIGASAASMLIFILPSAFYIK-----LVKKEPMKSVQKIGA 475

  Fly   518 --YLIIGLGVLFGVIGI 532
              :|:.|:.|:.|.:.:
Human   476 LFFLLSGVLVMTGSMAL 492

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:444915	98/481 (20%)
SLC38A2	NP_061849.2	Regulates protein turnover upon amino acid deprivation. /evidence=ECO:0000250	1..96		20/85 (24%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		4/12 (33%)
		SLC5-6-like_sbd	69..495	CDD:444915	97/478 (20%)