DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and slc32a1

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_001004943.1	Gene:	slc32a1 / 448348	XenbaseID:	XB-GENE-489830	Length:	518	Species:	Xenopus tropicalis

Alignment Length:	502	Identity:	219/502 - (43%)
Similarity:	300/502 - (59%)	Gaps:	42/502 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    49 HSQQAQHKAMEAGMDGGDTTEMSSNPFRNAGSWTNDGEGGGDGDGEYRNEYQSTSFNEYDGRYQQ 113
            |.|..|...::..:..||.|                    .:||..|                 |
Frog    54 HRQGLQMDILKTEVPSGDPT--------------------AEGDSHY-----------------Q 81

  Fly   114 TDGFRQGSIASEGSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVLHGGYWAIVAMV 178
            .||....|.||:......|....|..||..::|.|||||||||||::.||:|:|||||..:..::
Frog    82 RDGTGPPSSASKDEGLCSELSSYGKPKITAWEAGWNVTNAIQGMFVLGLPYAILHGGYLGLFLII 146

  Fly   179 GIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYVAIAKVCFG---PKLGARAVSIAQLIELLMT 240
            ..|.:||||||:|:.|||| :...|:.||||||||.||..|..   ||||.|.|::||:|||:||
Frog   147 FAAVVCCYTGKILIACLYE-ENEDGETVRVRDSYVDIANACCAPRFPKLGGRVVNVAQIIELVMT 210

  Fly   241 CILYVVVCGDLLAGTYPQGSFDSRSWMLFVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINAVIL 305
            |||||||.|:|:..::|......:||.:.....|||..|||:||.||..|..||::|.|||.:::
Frog   211 CILYVVVSGNLMYNSFPSLPISQKSWSIIATAMLLPCAFLKNLKAVSKFSLLCTLAHFVINVLVI 275

  Fly   306 GYCLLQIGDWGWSKVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAA 370
            .|||.:..||.|.||:|.||::.||||:|:||||||||||||:|||||....:|:.|::|:||||
Frog   276 AYCLSRARDWAWDKVKFYIDVKKFPISIGIIVFSYTSQIFLPSLEGNMQSPKEFHCMMNWTHIAA 340

  Fly   371 AVFKAGFGYICFLTFQNDTQQVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFR 435
            .:.|..|..:.:||:.::|::|||:||.|. .:.:||.|||.|||||||||::||.|:||::.|:
Frog   341 CILKGLFALVAYLTWADETKEVITDNLPST-IRAVVNLFLVAKALLSYPLPFFAAVEVLEKSLFQ 404

  Fly   436 GPPKTKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYF 500
            ...:..||..:..||.||.|||..|..::|.|:||||::|||::|||..||.||..|.|:.|..|
Frog   405 EGARAFFPNCYGGDGRLKSWGLTLRCALVVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLF 469

  Fly   501 HIKIKGHLLDQKEIAKDYLIIGLGVLFGVIGIYDSGNALINAFEIGL 547
            |:|:....|...::..|..|..:|.:..|.|...|...||.||...:
Frog   470 HLKLLWRKLQWHQVFFDVSIFVIGSICSVSGFVHSLEGLIEAFRFNI 516

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	195/391 (50%)
slc32a1	NP_001004943.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	66..98		12/68 (18%)
slc32a1	NP_001004943.1	Aa_trans	108..505	CDD:279788	197/398 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	405	1.000	Domainoid score	I705
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56451
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1744
OMA	1	1.010	-	-		QHG52048
OrthoDB	1	1.010	-	-		D321223at33208
OrthoFinder	1	1.000	-	-		FOG0007337
OrthoInspector	1	1.000	-	-		oto102203
Panther	1	1.100	-	-	LDO	PTHR48017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2046
SonicParanoid	1	1.000	-	-		X361
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110