DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and slc38a7

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_001003648.1	Gene:	slc38a7 / 445254	ZFINID:	ZDB-GENE-040801-266	Length:	465	Species:	Danio rerio

Alignment Length:	528	Identity:	113/528 - (21%)
Similarity:	187/528 - (35%)	Gaps:	133/528 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    72 SNPFR----NAGSWTNDGEGGGDGDGEYRNEYQSTSFNEYDGRYQQTDGFRQGSIASEGSSFVCE 132
            |.|.|    .||.|     |..:..||.....||.|.:......|..|.  :|..:|.|:.|:
Zfish     2 SRPDRAINSEAGDW-----GYSEDAGERAWLLQSPSVDSVQPPSQSDDS--RGGTSSLGAVFI-- 57

  Fly   133 GEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAV-LHGGYWAIVAMVGIAHICCYTGKV-LVQCL 195
                             |.||..|..:::.|.|. :.||..|.|.:.........||.| |..|.
Zfish    58 -----------------VVNAALGAGLLNFPAAFNMAGGITAGVTLQMCMMAFIITGLVILAYCS 105

  Fly   196 YEPDPATGQMVRVRDSYVAIAKVCFGPKLGARAVSIAQLIELLMTCILYVVVCGDLLAGTYPQGS 260
            ...:.:|.|.|        :..|| |..||. ...:|..:....|||.::::.||.|....  |:
Zfish   106 QVSNESTYQEV--------VRAVC-GKALGV-ICELAIAVYTFGTCIAFLIIIGDQLDKLI--GA 158

  Fly   261 FDSRS-------W--------MLFVGIFLLPMGFLKSL---KMVSTLSFWCTMSHIVINAVILGY 307
            .::.|       |        .|...:.:||:...|.:   |..||||...|....:|  ||:.|
Zfish   159 INNESEKEISLHWYTDRKFTITLTSVLIILPLSIPKEIGFQKYASTLSVIGTWYVTII--VIVKY 221

  Fly   308 C---------LLQIGDWGWSKVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWML 363
            .         ::.:....|:      |:.|   ::..|.|.:...:....:..:|.......|
Zfish   222 IWPSKDVSPGIIPVRPASWT------DVFN---AMPTICFGFQCHVSSVPVFNSMKKPEIRPW-- 275

  Fly   364 DWSHIAAAVFKAGFGY----IC-FLTFQNDTQQVITNNLHSQGFK-GMVNFFLVIKALLSYPLPY 422
             |..:..::....|.|    :| ||:|.:...|.:..:..|.... .:...|::|..:.|||:.:
Zfish   276 -WGVVTISMIICLFVYTGTGVCGFLSFGSSVSQDVLMSYPSDDVAVAIARAFIIICVVTSYPILH 339

  Fly   423 YAACELLERNFFRGPPKTKFPTIWNLDGE----------------LKVWGLGFRVGVIVSTILMA 471
            :....:||..:.|            ..||                ..||        ...|:::|
Zfish   340 FCGRAVLEGLWLR------------FKGEEVETDVAKERRRRILQTLVW--------FCLTLILA 384

  Fly   472 IFIPHFSILMGFIGSFTGTMLSFIWP--CYFHIKIKGHLLDQKEIAKDYLIIGLGVLFGVIGIYD 534
            :|||....::..||......: |::|  |....|:..|  |.:..:.: .::..||:...||.:.
Zfish   385 LFIPDIGRVISLIGGLAACFI-FVFPGLCLIQAKLSEH--DVRSNSWN-AMVAYGVIMVTIGAFI 445

  Fly   535 SGNALINA 542
            .|....||
Zfish   446 FGQTTTNA 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	92/441 (21%)
slc38a7	NP_001003648.1	SLC5-6-like_sbd	47..454	CDD:294310	99/476 (21%)
slc38a7	NP_001003648.1	SdaC	47..446	CDD:223884	96/467 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170594488
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740