DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc38a9

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_001030328.1	Gene:	Slc38a9 / 310091	RGDID:	1311881	Length:	559	Species:	Rattus norvegicus

Alignment Length:	492	Identity:	93/492 - (18%)
Similarity:	179/492 - (36%)	Gaps:	130/492 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   126 GSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVLHGGY---WAIVAMVGIAHI-CCY 186
            ||::..:....|..|.......:.:.|.:.|..|:|:|:.:...|:   ..::.::|:..: |||
  Rat   101 GSAYKLKSYTEGYRKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIVLMGLLTLYCCY 165

  Fly   187 TGKVLVQCLYEPDPATGQMVRVRDSYVAIAKVCFGPKLGARAVSIAQLIELLMTCILYVVVCGDL 251
            ........:...|..|.:       |..:.|..|| ..|..:..:..|:.|:...|:|.|:..:.
  Rat   166 RVVKSRSMIVTSDTTTWE-------YPDVCKHYFG-SFGQWSSLLFSLVSLIGAMIVYWVLMSNF 222

  Fly   252 LAGT----------------------------------YPQGS----FDS--------RSW---- 266
            |..|                                  :|..|    ::|        |.|
  Rat   223 LFNTGKFIFNFIHHINDTDTVLSTNNSSPVICPSAGSGHPDNSSMIFYNSDTEVRLFERWWDKSK 287

  Fly   267 ---MLFVGIFLLPM------GFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGW-SKVR 321
               ...:|: |||:      .|.....::.|:|....:..:.:.|:.||:.|    ::.| :...
  Rat   288 TVPFYLIGL-LLPLLNFKSPSFFSKFNILGTVSVLYLIFIVTLKAIRLGFHL----EFHWFAPTE 347

  Fly   322 FSID--MENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLT 384
            |.:.  ...||...||:..::.....:.||..|  ::::.|.:.|.. ||..:....:.||..|.
  Rat   348 FFVPEIRAQFPQLTGVLTLAFFIHNCIITLLKN--NKNQENNVRDLC-IAYMLVTLTYLYIGVLV 409

  Fly   385 FQNDTQQVITNNLHSQGFKGMVNF------------FLVIKALLSYP-LPYYAACELLERNFFRG 436
            |.:.....:..:...|.|  :.||            .|:.:.:..|| |.|.|..:||...|
  Rat   410 FASFPSPPLPKDCIEQNF--LDNFPSSDTLSFIARICLLFQMMTVYPLLGYLARVQLLGHIF--- 469

  Fly   437 PPKTKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFH 501
              ...:|:|:::        |...:.::.:.:.||.|.|:...::.:.|:..|....||:|...:
  Rat   470 --GDIYPSIFHV--------LILNLIIVGAGVTMACFYPNIGGIIRYSGAACGLAFVFIYPSLIY 524

  Fly   502 I------------KIKGHLLDQKEIAKDYLIIGLGVL 526
            |            |:..|::        .:|:||..|
  Rat   525 ILSQHQEERLTWPKLVFHII--------IIILGLANL 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	89/474 (19%)
Slc38a9	NP_001030328.1	SLC5-6-like_sbd	114..555	CDD:382020	90/479 (19%)
Slc38a9	NP_001030328.1	Important for arginine binding and amino acid transport. /evidence=ECO:0000250\|UniProtKB:Q08BA4	128..133		1/4 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900