DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc38a6

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_001013117.1	Gene:	Slc38a6 / 299139	RGDID:	1310330	Length:	457	Species:	Rattus norvegicus

Alignment Length:	487	Identity:	98/487 - (20%)
Similarity:	180/487 - (36%)	Gaps:	134/487 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   118 RQGSIASEGSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVLHGGYWAI-VAMVGIA 181
            |||   |.|:||        |..:      :||.|||.|..|:.|.:.:.:.|.... ..::.:|
  Rat    40 RQG---SSGASF--------GLSV------FNVMNAIMGSGILGLAYVMANTGILGFSFLLLLVA 87

  Fly   182 HICCYTGKVLV-QCLYEPDPATGQMVRVRDSYVAIAKVCFG--PKLGARAVSIAQLIELLMTCIL 243
            .:..|:..:|: .|::          ....||..:....||  .|:......|.|.|..:.:.:|
  Rat    88 LLASYSVHLLLAMCIH----------TAVTSYEDLGLFAFGLPGKVVVAGTIIIQNIGAMSSYLL 142

  Fly   244 YV-----VVCGDLLAGTYPQGSFDSRSW---------MLFVGIF----LLP----MGFLKSLK-- 284
            .:     ....::|...:      |.:|         ::.|||.    |||    :|:..||.
  Rat   143 IIKTELPAAISEVLPSDH------SGAWYLDGQMLLIIICVGIVFPLSLLPKIGFLGYTSSLSFF 201

  Fly   285 ------MVSTLSFW---CTMSHIVINAVILGYCLLQIGDWGWSKVRFSIDMENFPISLGVIVFSY 340
                  :|..:..|   |.::...||||                  |.|..........:..||.
  Rat   202 FMVFFALVVVIKKWAVPCPLTLNCINAV------------------FQISNATDDCKPKLFHFSK 248

  Fly   341 TSQIFLPTLEGNMIDRSKF------------NWMLDWSHIAAAV------FKAGFGYICFL-TFQ 386
            .|...:||:..:.:..:..            ..|.:.::.|.|:      ..|.|||:.|. ..:
  Rat   249 ESVYAIPTMAFSFLCHTSVLPIYCELRSPSKKRMQNVTNTAIALSFLVYFVSALFGYLTFYDKVE 313

  Fly   387 NDTQQVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLDGE 451
            ::..|..:..|........|...::...||:.||.::.|.:.|....|     :.:|..| :...
  Rat   314 SELLQGYSKYLPHDAAVMAVKLCILFAVLLTVPLIHFPARKALMMILF-----SNYPFSW-IRHS 372

  Fly   452 LKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKI-KGHLLDQKEIA 515
            |....|    .:|:  :|:||::|....:.|.:|:.|.|.|.|::|..|::|: :...|..|::
  Rat   373 LTTLAL----NIII--VLLAIYVPDIRNVFGVVGASTSTCLIFVFPGLFYLKLSREDFLSWKKL- 430

  Fly   516 KDYLIIGLGVLFGVIGIYDSGNALINAFEIGL 547
                        |.:.:..:| .::.:|.:.|
  Rat   431 ------------GALSLLSTG-TVVGSFSLVL 449

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	87/445 (20%)
Slc38a6	NP_001013117.1	SLC5-6-like_sbd	45..452	CDD:294310	94/479 (20%)
Slc38a6	NP_001013117.1	SdaC	45..447	CDD:223884	93/475 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810