DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc38a2

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	XP_006242344.1	Gene:	Slc38a2 / 29642	RGDID:	69420	Length:	535	Species:	Rattus norvegicus

Alignment Length:	573	Identity:	123/573 - (21%)
Similarity:	209/573 - (36%)	Gaps:	163/573 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 TEM---SSNPFRNAGSWTNDGEGGGDGDGEYRNEYQSTSFNEYDGRYQQTDGFRQGSIASEGSSF 129
            |||   :.:|..::.|:::      :||..|....:..:...:   |...|        .|..:|
  Rat     4 TEMGRFNISPDEDSSSYSS------NGDFNYSYPTKQAALKSH---YVDVD--------PENQNF 51

  Fly   130 VCEGEGGGGCKIDEF--------QAAWNVTNAIQGMFIVSLPFAVLHGG---YWAIVAMVGI--- 180
            :.|...|......:|        .:.:|::|||.|..|:.|.:|:.:.|   :..::..|.|
  Rat    52 LLESNLGKKKYETDFHPGTTSFGMSVFNLSNAIVGSGILGLSYAMANTGIALFIILLTFVSIFSL 116

  Fly   181 --AHICCYTGKVLVQCLYE---------------PDPATGQMVRVRDSYVAIAKVCFGPKLGARA 228
              .|:...|.......|||               ....|.|.:....||:.|.|
  Rat   117 YSVHLLLKTANEGGSLLYEQLGHKAYGLAGKLAASGSITMQNIGAMSSYLFIVK----------- 170

  Fly   229 VSIAQLIELLMTC-----ILYVVVCGDLLAGTYPQGSFDSRSWMLFVGIFLLPMGFLKSLKMV-- 286
            ..:..:|:.||..     :.|  :.||.|.             :|...:.:||:..|::|..:
  Rat   171 YELPLVIKALMNIEDTNGLWY--LNGDYLV-------------LLVSFVLILPLSLLRNLGYLGY 220

  Fly   287 -STLSFWCTMSHIVINAVILGYC-------------LLQIGDWGWSKV--RFSIDMENFPISLGV 335
             |.||..|.:..:::..|::..|             ||....:....:  :|.|..   |:.:.:
  Rat   221 TSGLSLLCMIFFLIVVGVVVFVCRKCILKALSGHPALLTSAIFCCQVICKKFQIPC---PVEVAL 282

  Fly   336 I----VFSYTSQIFLPTLEGN--MIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDTQQVIT 394
            :    |....:|:.|..|..|  ..|..:..:.:..|....||....|.::|     :.....|.
  Rat   283 MANETVNGTFTQVALAALASNSTAADTCRPRYFIFNSQTVYAVPILTFSFVC-----HPAVLPIY 342

  Fly   395 NNLHSQGFKGMVN-----FF-----LVIKALLSYPLPYY--AACELLER-NFFRGP--------- 437
            ..|.|:..:.|:|     ||     .::.||..| |.:|  ...|||.. :...|.
  Rat   343 EELKSRSRRRMMNVSKISFFAMFLMYLLAALFGY-LTFYEHVESELLHTYSAIVGTDILLLVVRL 406

  Fly   438 ----------PKTKFP---TIWNLDGELK--VWGLGFRVGVIVSTI-----LMAIFIPHFSILMG 482
                      |...||   ::.:|....|  .|   ||..||..||     |:.||:|....:.|
  Rat   407 AVLVAVTLTVPVVIFPIRSSVTHLLCPTKEFSW---FRHSVITVTILAFTNLLVIFVPTIRDIFG 468

  Fly   483 FIGSFTGTMLSFIWPCYFHIKI--KGHLLDQKEI-AKDYLIIGLGVLFGVIGI 532
            |||:....||.||.|..|:||:  |..:...::| |..:|:.|:.|:.|.:|:
  Rat   469 FIGASAAAMLIFILPSAFYIKLVKKEPMRSVQKIGALCFLLSGVVVMIGSMGL 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	109/494 (22%)
Slc38a2	XP_006242344.1	SdaC	64..516	CDD:223884	107/489 (22%)
Slc38a2	XP_006242344.1	SLC5-6-like_sbd	69..518	CDD:294310	106/486 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352545
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740