Protein Alignment VGAT and SLC36A3

DIOPT Version :10

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_001138489.1
• Gene: SLC36A3 / 285641
• HGNCID: 19659
• Length: 511
• Species: Homo sapiens
• Alignment Length: 449
• Identity: 90/449 - (20%)
• Similarity: 161/449 - (35%)
• Gaps: 98/449 - (21%)

  Fly   139 CKIDEFQAAWNVTNAIQGMFIVSLPFAVLHG---------------GYWAIVAMVGIAHICCYTG 188
            |.:.....|.:::..:|..| |:...|.::|               |.|.:...   ..:.| :|
Human    89 CMVILLNCAQHLSQRLQKTF-VNYGEATMYGLETCPNTWLRAHAVWGRWNLALS---PRLEC-SG 148

  Fly   189 KVLVQC---LYEPDPATGQMVRVRDSYVAIAKVCFGPKLGARAVSIAQLIELLMTCILYVVVCGD 250
            |:...|   |.....:..|..||...|             ...||...:|..|..|.:|.:...|
Human   149 KISAHCNPHLQGSSNSPAQASRVAGIY-------------RYTVSFLLVITQLGFCSVYFMFMAD 200

  Fly   251 LLAGTYPQGS-----------------FDSRSWMLFVGIFLLPMGFLKSLKMVSTLSFWCTMSHI 298
            .|.....:..                 .|.|.:||.:..||:.:.|:::||::|..|....::.:
Human   201 NLQQMVEKAHVTSNICQPREILTLTPILDIRFYMLIILPFLILLVFIQNLKVLSVFSTLANITTL 265

  Fly   299 VINAVILGYCLLQI---------GDWGWSKVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNMI 354
            ...|:|..|.:..|         .:|           :.|.:..|..:|::.....:..|:..|.
Human   266 GSMALIFEYIMEGIPYPSNLPLMANW-----------KTFLLFFGTAIFTFEGVGMVLPLKNQMK 319

  Fly   355 DRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDTQQVITNNLHSQGFKGMVNFFLVIKALLSYP 419
            ...:|:::|........:.....|.:.::.|.:|||..||.||.:......|.....|....:|.
Human   320 HPQQFSFVLYLGMSIVIILYILLGTLGYMKFGSDTQASITLNLPNCWLYQSVKLMYSIGIFFTYA 384

  Fly   420 LPYYAACELLERNFFRGPPKTKFP-------TIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHF 477
            |.::...|::            .|       ..|.|..:|.|     |..::..|.:.||.||..
Human   385 LQFHVPAEII------------IPFAISQVSESWALFVDLSV-----RSALVCLTCVSAILIPRL 432

  Fly   478 SILMGFIGSFTGTMLSFIWPCYFHIKI-KGHLLDQKEIAKDYLIIGLGVLFGVIGIYDS 535
            .:::..:||.:.:.|:.|.|....|.| ....:....||||.:|..:|:|..:.|.|.:
Human   433 DLVISLVGSVSSSALALIIPALLEIVIFYSEDMSCVTIAKDIMISIVGLLGCIFGTYQA 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:444915	88/440 (20%)
SLC36A3	NP_001138489.1	SLC5-6-like_sbd	41..492	CDD:444915	90/449 (20%)