DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc36a2

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_647555.2	Gene:	Slc36a2 / 246235	RGDID:	620492	Length:	481	Species:	Rattus norvegicus

Alignment Length:	489	Identity:	115/489 - (23%)
Similarity:	189/489 - (38%)	Gaps:	91/489 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 SFNEYDGRYQQTDGFRQGSIASEGSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVL 167
            ||.|...:.|..|.......:||.|    |...|    |..||...::.....|..|:.||.||.
  Rat    22 SFPESAKKVQSQDPNPVNGSSSESS----EKTKG----ITGFQTLVHLVKGNMGTGILGLPLAVK 78

  Fly   168 HGG-YWAIVAMVGIAHICCYTGKVLVQC-------LYEPDPATGQMVRVRDSYVAIAKVCFGPKL 224
            :.| ....::::.:..|.|:...:||:|       |.:|....|..|        :..:...|..
  Rat    79 NAGILMGPLSLLVMGLIACHCMHILVRCAQRFCHRLNKPFMDYGDTV--------MHGLASSPNT 135

  Fly   225 --------GARAVSIAQLIELLMTCILYVVVCGDLLAGTYP-----------------QGSFDSR 264
                    |...||...::..|..|.:|:|...|.|.....                 ..:.|||
  Rat   136 WLQSHAHWGRHVVSFFLIVTQLGFCCVYIVFLADNLKQVVEAVNSTTISCHKNETVVLTPTIDSR 200

  Fly   265 SWMLFVGIFLLPMG---FLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGWSKVRFSIDM 326
            .:||   .||..:|   |:::|::::..|....:|.:|...:|..|.:..|.|  .|::......
  Rat   201 LYML---AFLPVLGLLVFIRNLRVLTIFSLLANVSMLVSLVIIAQYIIQGIPD--PSQLPLVASW 260

  Fly   327 ENFPISLGVIVFSYTS-QIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDTQ 390
            :.:|:..|..:||:.| .:.|| ||..|.|..:|..:|..............|.:.:|.|.:|.:
  Rat   261 KTYPLFFGTAIFSFESIGVVLP-LENKMKDARRFPTILSLGMSIITTLYIAIGALGYLRFGDDIK 324

  Fly   391 QVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTI-------WNL 448
            ..||.||.:......|....|:..|.:|.|.:|...|::            .|..       |.|
  Rat   325 ASITLNLPNCWLYQSVKLLYVVGILCTYALQFYVPAEII------------IPLAVSQVSKRWAL 377

  Fly   449 DGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHI-KIKGHLLDQK 512
            ..:|.:     |:.::..|.::||.||...:::..:||.:.:.|:.|.|....: ...|..:...
  Rat   378 PVDLSI-----RLALVCLTCMLAILIPRLDLVLSLVGSVSSSALALIIPPLLEVTTYYGEGMSPL 437

  Fly   513 EIAKDYLIIGLGVLFGVIGIYD-------SGNAL 539
            .|.||.||..||.:..|:|.|.       |||:|
  Rat   438 TITKDALISILGFMGFVVGTYQALDELIRSGNSL 471

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	99/433 (23%)
Slc36a2	NP_647555.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	26..49		6/26 (23%)
Slc36a2	NP_647555.2	SLC5-6-like_sbd	50..461	CDD:382020	102/445 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352542
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740