DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc36a2

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_694810.2	Gene:	Slc36a2 / 246049	MGIID:	1891430	Length:	478	Species:	Mus musculus

Alignment Length:	447	Identity:	104/447 - (23%)
Similarity:	179/447 - (40%)	Gaps:	76/447 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 IDEFQAAWNVTNAIQGMFIVSLPFAVLHGG-YWAIVAMVGIAHICCYTGKVLVQC-------LYE 197
            |..||...::.....|..|:.||.||.:.| ....::::.:..|.|:...:||:|       |.:
Mouse    49 ITGFQTLVHLVKGNMGTGILGLPLAVKNAGILMGPLSLLVMGLIACHCMHILVRCAQRFCHRLNK 113

  Fly   198 PDPATGQMVRVRDSYVAIAKVCFGPKL--------GARAVSIAQLIELLMTCILYVVVCGDLLAG 254
            |....|..|        :..:.|.|..        |.|.||...::..|..|.:|:|...|.|..
Mouse   114 PFMDYGDTV--------MHGLAFSPNAWLQNHAHWGRRVVSFFLIVTQLGFCCVYIVFLADNLKQ 170

  Fly   255 TYP-----------------QGSFDSRSWMLFVGIFLLPMG---FLKSLKMVSTLSFWCTMSHIV 299
            ...                 ..:.|||.:||   .||..:|   |:::|::::..|....:|.:|
Mouse   171 VVEAVNSTTISCHKNETVVLTPTMDSRLYML---SFLPVLGLLVFVRNLRVLTIFSLLANISMLV 232

  Fly   300 INAVILGYCLLQIGDWGWSKVRFSIDMENFPISLGVIVFSYTS-QIFLPTLEGNMIDRSKFNWML 363
            ...:|..|.:.:|.|  .|::......:.:|:..|..:||:.| .:.|| ||..|.|...|..:|
Mouse   233 SLVIIAQYIIQEIPD--ASQLPLVASWKTYPLFFGTAIFSFESIGVVLP-LENKMKDARGFPTIL 294

  Fly   364 DWSHIAAAVFKAGFGYICFLTFQNDTQQVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAACEL 428
            ..............|.:.:|.|.:|.:..||.||.:......|....|:..|.:|.|.:|...|:
Mouse   295 SLGMSIITTLYIAIGALGYLRFGDDIKASITLNLPNCWLYQSVKLLYVVGILCTYALQFYVPAEI 359

  Fly   429 LERNFFRGPPKTKFPTI-------WNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGS 486
            :            .|..       |.|..:|.:     |:.::..|.::||.||...:::..:||
Mouse   360 I------------IPLAVSQVSKRWALPVDLSI-----RLALVCLTCMLAILIPRLDLVLSLVGS 407

  Fly   487 FTGTMLSFIWPCYFH-IKIKGHLLDQKEIAKDYLIIGLGVLFGVIGIYDSGNALINA 542
            .:.:.|:.|.|.... :...|..:....:.||.||..||.:..|:|.|.:.:.||.:
Mouse   408 VSSSALALIIPPLLEVVTYYGEGISPLTVTKDALISILGFMGFVVGTYQALDELIKS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	100/433 (23%)
Slc36a2	NP_694810.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
Slc36a2	NP_694810.2	SLC5-6-like_sbd	48..458	CDD:294310	102/439 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848934
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740