DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc36a4

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_758493.2	Gene:	Slc36a4 / 234967	MGIID:	2442595	Length:	500	Species:	Mus musculus

Alignment Length:	489	Identity:	106/489 - (21%)
Similarity:	189/489 - (38%)	Gaps:	115/489 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 NE--YDGRYQQTDGFRQGSIASEGSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVL 167
            ||  :||   .:|..::.::......:..:|:.|    |...|...::.....|..::.||.|:.
Mouse    25 NEQNFDG---SSDEEQEQTLVPIQKHYQLDGQHG----ISFLQTLVHLLKGNIGTGLLGLPLAIK 82

  Fly   168 HGGYWAIV------AMVGIAHICCYTGKVLVQCLY-----EPDPATGQMVRVRDSYVAIAKVCFG 221
            :.|   ||      ..:||..:.|.  .:||:|.:     ......|....|..:..|....|..
Mouse    83 NAG---IVLGPISLVFIGIISVHCM--HILVRCSHFLCQRFKKSTLGYSDTVSFAMEASPWSCLQ 142

  Fly   222 PKL--GARAVSIAQLIELLMTCILYVVVC--------------------GDLLAGTYPQGSFDSR 264
            .:.  |...|....:|..|..|.:|:|..                    |..|:....:.|.|.|
Mouse   143 RQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEGFLGSTPIVSNGSDLSHACERRSVDLR 207

  Fly   265 SWML-FVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGD-------WGWSKVR 321
            .:|| |:.:.:| :.|::.||.:..|||...:|......:|..|.:..:.|       .||.|
Mouse   208 VYMLCFLPLIIL-LVFIRELKNLFVLSFLANISMAASLVIIYQYVVRNMPDPHNLPIVAGWKK-- 269

  Fly   322 FSIDMENFPISLGVIVFSYTS-QIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFK------AGFGY 379
                   :|:..|..||::.. .:.|| ||..|.:..:|...|   :|..|:..      |..||
Mouse   270 -------YPLFFGTAVFAFEGIGVVLP-LENQMRESKRFPQAL---NIGMAIVTVLYISLATLGY 323

  Fly   380 ICFLTFQNDTQQVITNNLHS-----QGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPK 439
            :|   |:::.:..||.||..     |..|.:.:|.:.:    :|.:.:|...|::.      |..
Mouse   324 MC---FRDEIKGSITLNLPQDMWLYQSVKILYSFGIFV----TYSIQFYVPAEIII------PGV 375

  Fly   440 T-KFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIK 503
            | :....|.     ::...|.|..::..|...||.||...|::.|:|:.:.:.|:.|.|
Mouse   376 TARLHAKWK-----RICEFGIRSLLVSITCAGAILIPRLDIVISFVGAVSSSTLALILP------ 429

  Fly   504 IKGHLLDQKEIAKDY-----LIIGLGVLF-GVIG 531
               .|::....:||:     ::..:.:.| ||:|
Mouse   430 ---PLVEILTFSKDHYNIWMILKNISIAFTGVVG 460

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	98/448 (22%)
Slc36a4	NP_758493.2	SLC5-6-like_sbd	54..469	CDD:294310	100/457 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848932
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740