DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc38a7

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_766346.1	Gene:	Slc38a7 / 234595	MGIID:	2679005	Length:	463	Species:	Mus musculus

Alignment Length:	569	Identity:	111/569 - (19%)
Similarity:	196/569 - (34%)	Gaps:	160/569 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QIPERKDYEQPPGSTAQQHHHSQQAQHKAMEAGMDGGDTTEMSSNPFRNAGSWTNDGEGG-GDGD 92
            |:....||.:...||                   |.|:...:..:|..:... .::||.. ||.|
Mouse     3 QVSINSDYSEWASST-------------------DAGERARLLQSPCVDVVP-KSEGEASPGDPD 47

  Fly    93 GEYRNEYQSTSFNEYDGRYQQTDGFRQGSIASEGSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGM 157
                                      .|:.::.|:.|:                   |.||..|.
Mouse    48 --------------------------SGTTSTLGAVFI-------------------VVNACLGA 67

  Fly   158 FIVSLPFAV-LHGGYWAIVAM-VGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYVAIAKVCF 220
            .:::.|.|. ..||..|.:|: :|:.........:|..|....:..|.|.|        :..||
Mouse    68 GLLNFPAAFSTAGGVAAGIALQMGMLVFIISGLVILAYCSQASNERTYQEV--------VWAVC- 123

  Fly   221 GPKLGARAVSIAQLIELLMTCILYVVVCGD------LLAGTYPQGSFDSRSW--------MLFVG 271
             .||......:|..:....|||.::::.||      .:....|.|:..| .|        .|...
Mouse   124 -GKLTGVLCEVAIAVYTFGTCIAFLIIIGDQQDKIIAVMSKEPDGASGS-PWYTDRKFTISLTAF 186

  Fly   272 IFLLPM------GFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGWSKVRFSIDMENFP 330
            :|:||:      ||.|....:|.:..|...:.|:|..:           |...::|.. |:...|
Mouse   187 LFILPLSIPKEIGFQKYASFLSVVGTWYVTAIIIIKYI-----------WPDKEMRPG-DILTRP 239

  Fly   331 IS-------LGVIVFSYTSQIFLPTLEGNMIDRSKFNW-------MLDWSHIAAAVFKAGFGYIC 381
            .|       :..|.|.:...:....:..:|.......|       |:    ||.||: .|.|...
Mouse   240 ASWMAVFNAMPTICFGFQCHVSSVPVFNSMRQPEVKTWGGVVTAAMV----IALAVY-MGTGICG 299

  Fly   382 FLTFQNDTQQVITNNLHSQGFK-GMVNFFLVIKALLSYPLPYYAACELLERNF--FRGPP----- 438
            ||||.......:..:..|:... .:...|:::..|.|||:.::....::|..:  ::|.|
Mouse   300 FLTFGAAVDPDVLRSYPSEDVAVAVARAFIILSVLTSYPILHFCGRAVVEGLWLRYKGMPVEEDV 364

  Fly   439 -----KTKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPC 498
                 :....|:        ||        .:.|:|:|:|||....::..||......: ||:|.
Mouse   365 GRERRRRVLQTL--------VW--------FLLTLLLALFIPDIGKVISVIGGLAACFI-FIFPG 412

  Fly   499 YFHIKIKGHLLDQKEIAKDYLIIGLGVLFGVIGIYDSGNALINAFEIGL 547
            ...|:.|...:::.:.|..:.::..|||...:|.:..|....||..:.|
Mouse   413 LCLIQAKLSEMEEVKPASWWALVSYGVLLVTLGAFIFGQTTANAIFVDL 461

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	91/437 (21%)
Slc38a7	NP_766346.1	SLC5-6-like_sbd	49..458	CDD:382020	97/472 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167848933
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740