Protein Alignment VGAT and SLC36A1

DIOPT Version :10

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: XP_047272876.1
• Gene: SLC36A1 / 206358
• HGNCID: 18761
• Length: 507
• Species: Homo sapiens
• Alignment Length: 546
• Identity: 123/546 - (22%)
• Similarity: 208/546 - (38%)
• Gaps: 104/546 - (19%)

  Fly    43 TAQQHHHSQQAQHKAMEA-GMDGGDT--TEMSSNPFRNAGSWTNDGEGGGDGDGEYRNEYQSTSF 104
            ||.....:...:.||..| |::.|..  ..||:...||                |..::|.||..
Human     2 TASTPEATPNMELKAPAAGGLNAGPVPPAAMSTQRLRN----------------EDYHDYSSTDV 50

  Fly   105 NEYDGRYQQTDGFRQGSIASEGS--SFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVL 167
            :..:   ..::|.  .:::|.||  .|      |.......||...::.....|..::.||.||.
Human    51 SPEE---SPSEGL--NNLSSPGSYQRF------GQSNSTTWFQTLIHLLKGNIGTGLLGLPLAVK 104

  Fly   168 HGGYWAIV------AMVGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYVAIA-KVCFG---- 221
            :.|   ||      .::||..:.|.  .:||:|.:.      ...|:..|:|... .|.:|
Human   105 NAG---IVMGPISLLIIGIVAVHCM--GILVKCAHH------FCRRLNKSFVDYGDTVMYGLESS 158

  Fly   222 --------PKLGARAVSIAQLIELLMTCILYVVVCGDLLAGTYPQ-------------------- 258
                    ...|.|.|....::..|..|.:|.|    .||..:.|
Human   159 PCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFV----FLADNFKQVIEAANGTTNNCHNNETVIL 219

  Fly   259 -GSFDSRSWMLFVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGWSKVRF 322
             .:.|||.:||....||:.:.|:::|:.:|..|....::.:|...:|..:.:.:|.|  .|.:..
Human   220 TPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRIPD--PSHLPL 282

  Fly   323 SIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQN 387
            ....:.:|:..|..:||:.....:..||..|.|..||..:|....:...:.....|.:.:|.|..
Human   283 VAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISLGCLGYLQFGA 347

  Fly   388 DTQQVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLDGEL 452
            :.|..||.||.:......|.....|....:|.|.:|...|::...|....|:         ..||
Human   348 NIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPE---------HCEL 403

  Fly   453 KVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKI---KGHLLDQKEI 514
            .| .|..|..::..|.::||.||...:::..:||.:.:.|:.|.|....:..   :|  :....|
Human   404 VV-DLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYSEG--MSPLTI 465

  Fly   515 AKDYLIIGLGVLFGVIGIYDSGNALI 540
            .||.||..||.:..|:|.|::...||
Human   466 FKDALISILGFVGFVVGTYEALYELI 491

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:444915	99/431 (23%)
SLC36A1	XP_047272876.1	SLC5-6-like_sbd	78..484	CDD:444915	99/434 (23%)