Protein Alignment VGAT and SLC36A1

DIOPT Version :9

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: XP_011535882.1
• Gene: SLC36A1 / 206358
• HGNCID: 18761
• Length: 482
• Species: Homo sapiens
• Alignment Length: 491
• Identity: 113/491 - (23%)
• Similarity: 190/491 - (38%)
• Gaps: 83/491 - (16%)

  Fly    96 RNE-YQSTSFNEYDGRYQQTDGFRQGSIASEGS--SFVCEGEGGGGCKIDEFQAAWNVTNAIQGM 157
            ||| |...|..:.......::|.  .:::|.||  .|      |.......||...::.....|.
Human    13 RNEDYHDYSSTDVSPEESPSEGL--NNLSSPGSYQRF------GQSNSTTWFQTLIHLLKGNIGT 69

  Fly   158 FIVSLPFAVLHGGYWAIV------AMVGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYVAIA 216
            .::.||.||.:.|   ||      .::||..:.|.  .:||:|.:.      ...|:..|:|...
Human    70 GLLGLPLAVKNAG---IVMGPISLLIIGIVAVHCM--GILVKCAHH------FCRRLNKSFVDYG 123

  Fly   217 -KVCFG------------PKLGARAVSIAQLIELLMTCILYVVVCGDLLAGTYPQ---------- 258
             .|.:|            ...|.|.|....::..|..|.:|.|    .||..:.|
Human   124 DTVMYGLESSPCSWLRNHAHWGRRVVDFFLIVTQLGFCCVYFV----FLADNFKQVIEAANGTTN 184

  Fly   259 -----------GSFDSRSWMLFVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQI 312
                       .:.|||.:||....||:.:.|:::|:.:|..|....::.:|...:|..:.:.:|
Human   185 NCHNNETVILTPTMDSRLYMLSFLPFLVLLVFIRNLRALSIFSLLANITMLVSLVMIYQFIVQRI 249

  Fly   313 GDWGWSKVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGF 377
            .|  .|.:......:.:|:..|..:||:.....:..||..|.|..||..:|....:...:.....
Human   250 PD--PSHLPLVAPWKTYPLFFGTAIFSFEGIGMVLPLENKMKDPRKFPLILYLGMVIVTILYISL 312

  Fly   378 GYICFLTFQNDTQQVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKF 442
            |.:.:|.|..:.|..||.||.:......|.....|....:|.|.:|...|::...|....|:
Human   313 GCLGYLQFGANIQGSITLNLPNCWLYQSVKLLYSIGIFFTYALQFYVPAEIIIPFFVSRAPE--- 374

  Fly   443 PTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKI--- 504
                  ..||.| .|..|..::..|.::||.||...:::..:||.:.:.|:.|.|....:..
Human   375 ------HCELVV-DLFVRTVLVCLTCILAILIPRLDLVISLVGSVSSSALALIIPPLLEVTTFYS 432

  Fly   505 KGHLLDQKEIAKDYLIIGLGVLFGVIGIYDSGNALI 540
            :|  :....|.||.||..||.:..|:|.|::...||
Human   433 EG--MSPLTIFKDALISILGFVGFVVGTYEALYELI 466

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	99/431 (23%)
SLC36A1	XP_011535882.1	SLC5-6-like_sbd	53..459	CDD:294310	99/434 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158533
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740