DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Y32F6A.4

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_505680.2	Gene:	Y32F6A.4 / 179456	WormBaseID:	WBGene00012529	Length:	519	Species:	Caenorhabditis elegans

Alignment Length:	524	Identity:	117/524 - (22%)
Similarity:	191/524 - (36%)	Gaps:	147/524 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 SFNEYDGRYQQTDGFRQG---SIASEGSSFVCEGEGGGGCKIDE----FQAA---WNVTNAIQGM 157
            ||:.....|...|..|:.   |..|...|:..|......|.:|.    |..|   |.||    |:
Worm     2 SFSLSRENYAFEDSCRKSTRTSSCSRRDSWNGETRSSSHCDVDMSKPFFNPAGLNWFVT----GL 62

  Fly   158 F---------IVSLPFAVLHGGYW-AIVAMVGIAHICCYTGKVL---VQCLYEPDPATGQMVRVR 209
            |         ||:||.|::...:| .::..|.:..:..||..||   ...|....|....  ..|
Worm    63 FVVGDLAGGGIVALPTAIIQAEFWTGLIVCVILIGVVTYTAYVLGLSWNILLSTWPEYRH--HCR 125

  Fly   210 DSYVAIAKVCFGPKLGARAVSIAQLIELLMTCILYVVVCGD-----------LLA---------- 253
            ..|         |::|.||:.        .||.|.|.:|.|           |||
Worm   126 KPY---------PEIGGRAMG--------KTCQLLVSICIDVTQFMISVVYLLLASKNIMNMIIA 173

  Fly   254 --GTYPQGSFDSRSWMLFVGIFLLPMGFLKSLKMVSTLSFW-------CTMSHIVINAVILGYCL 309
              ||:    ......:|.|...|||:.||||.:     .||       .|.|..|| .:|:|
Worm   174 FSGTH----ISFCILILIVATCLLPLCFLKSPQ-----DFWWAVVIAMMTTSAAVI-LIIVG--- 225

  Fly   310 LQIGDWG----WSKVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAA 370
             .|.|:|    ::|:. .....|..:|:|.::||.......||::.:|....:|         ..
Worm   226 -SIIDYGKCAPFAKLP-PFRTTNLFLSMGTLLFSVGGHSAFPTIQHDMKQPKEF---------TR 279

  Fly   371 AVFKA----GFGYI--C---FLTFQNDTQQVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAAC 426
            :||.|    .|.||  |   :|.:.:..:..|..::.:...:..:|..:.:..:|:..:.:....
Worm   280 SVFLAFTIMAFMYIPVCIMGYLVYGDSLRDSIIPSIQTVWIQQAINIMITVHCILTLTIVFNPLM 344

  Fly   427 ELLERNFF---RGPPKTKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFT 488
            :.:|..|.   |..||...                .|.|::|:.:.:|..:|.|..|:..:|..|
Worm   345 QEVEELFHVPQRFGPKRAI----------------VRTGIMVAVVFVAESVPTFGPLLDLVGGST 393

  Fly   489 GTMLSFIWPCYFHIKIKGHLLDQKEIAK---------DYLIIG------LGVLFGVIGIYDSGNA 538
            .|:.|.|.||.|:|.:..:...::...|         |.:...      :.::..:||:...|.|
Worm   394 LTLTSVIMPCLFYIYLNAYKRKEEITGKPGNGPVGWRDVITFNQKPTLCICIIIMIIGLIGGGCA 458

  Fly   539 LINA 542
            ..:|
Worm   459 TFSA 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	103/465 (22%)
Y32F6A.4	NP_505680.2	SLC5-6-like_sbd	54..415	CDD:382020	97/423 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D570025at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100570
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.720