DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment VGAT and unc-47

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_499255.1	Gene:	unc-47 / 176431	WormBaseID:	WBGene00006783	Length:	486	Species:	Caenorhabditis elegans

Alignment Length:	500	Identity:	209/500 - (41%)
Similarity:	291/500 - (58%)	Gaps:	47/500 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MSSNPFRNAGSWTN--------------------------DGEGGGDGDGEYRNE-YQSTSFNEY 107
            |:||.|:|..:|||                          .||.|.:.....|.| .|.:..:|
Worm     1 MASNRFQNLQNWTNKHVFSNSLDYWNQELNEVPSYQNQPQTGESGSNPPPHDRLEPIQESVVSE- 64

  Fly   108 DGRYQQTDGFRQGSIASEGSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVLHGGYW 172
               ..|.|...:...|.:      :|.|.....|...||||||||||||||||.||.||..||:|
Worm    65 ---QPQKDDINKQEEAKD------DGHGEASEPISALQAAWNVTNAIQGMFIVGLPIAVKVGGWW 120

  Fly   173 AIVAMVGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYVAIAKVCFGPKLGARAVSIAQLIEL 237
            :|.||||:|::|.:||.:|::||||      ..|:.|.:|..||.. :.|..| :.|..|||.||
Worm   121 SIGAMVGVAYVCYWTGVLLIECLYE------NGVKKRKTYREIADF-YKPGFG-KWVLAAQLTEL 177

  Fly   238 LMTCILYVVVCGDLLAGTYPQGSFDSRSWMLFVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINA 302
            |.|||:|:|:..|||...:|  |.|...||:.....||...||..|::||.|||:..:||:::|.
Worm   178 LSTCIIYLVLAADLLQSCFP--SVDKAGWMMITSASLLTCSFLDDLQIVSRLSFFNAISHLIVNL 240

  Fly   303 VILGYCLLQIGDWGWSKVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSH 367
            :::.|||..:..|.:|.:.||:::...|..:|::||.|||.||||.|||||.:.::||.||.|||
Worm   241 IMVLYCLSFVSQWSFSTITFSLNINTLPTIVGMVVFGYTSHIFLPNLEGNMKNPAQFNVMLKWSH 305

  Fly   368 IAAAVFKAGFGYICFLTFQNDTQQVITNNLHSQGFKGMVNFFLVIKALLSYPLPYYAACELLERN 432
            |||||||..||.:.||||...||:.|:|:|.:|.||.:||..||:|||||||||:|||.:||:.|
Worm   306 IAAAVFKVVFGMLGFLTFGELTQEEISNSLPNQSFKILVNLILVVKALLSYPLPFYAAVQLLKNN 370

  Fly   433 FFRGPPKTKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWP 497
            .|.|.|:|.|.:.::.|..|:.|.:..|:.:::.|:.:|:.:|:...|||.:|:.||||||||||
Worm   371 LFLGYPQTPFTSCYSPDKSLREWAVTLRIILVLFTLFVALSVPYLVELMGLVGNITGTMLSFIWP 435

  Fly   498 CYFHIKIKGHLLDQKEIAKDYLIIGLGVLFGVIGIYDSGNALINA 542
            ..||:.||...|:..|...|..||.:|....:.|:|.|...|:.|
Worm   436 ALFHLYIKEKTLNNFEKRFDQGIIIMGCSVCISGVYFSSMELLRA 480

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	184/388 (47%)
unc-47	NP_499255.1	Aa_trans	88..475	CDD:279788	187/396 (47%)
unc-47	NP_499255.1	SdaC	90..471	CDD:223884	184/390 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159314
Domainoid	1	1.000	355	1.000	Domainoid score	I516
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H56451
Inparanoid	1	1.050	365	1.000	Inparanoid score	I1260
Isobase	1	0.950	-	0	Normalized mean entropy	S2954
OMA	1	1.010	-	-		QHG52048
OrthoDB	1	1.010	-	-		D321223at33208
OrthoFinder	1	1.000	-	-		FOG0007337
OrthoInspector	1	1.000	-	-		oto20078
orthoMCL	1	0.900	-	-		OOG6_100570
Panther	1	1.100	-	-	LDO	PTHR48017
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2046
SonicParanoid	1	1.000	-	-		X361
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	17	16.790