DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and Slc36a1

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_569099.1	Gene:	Slc36a1 / 155205	RGDID:	619801	Length:	475	Species:	Rattus norvegicus

Alignment Length:	515	Identity:	112/515 - (21%)
Similarity:	190/515 - (36%)	Gaps:	110/515 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 MSSNPFRNAGSWTNDGEGGGDGDGEYRNEYQSTSFNEYDGRYQQTDGFRQGSI--ASEGSSFVCE 132
            ||:...||                |..::|.||..:..:...:....|..||.  ..|.||...
  Rat     1 MSTQRLRN----------------EDYHDYSSTDVSPEESPSEGLGSFSPGSYQRLGENSSMTW- 48

  Fly   133 GEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVLHGGYW---AIVAMVGIAHICCYTGKVLVQC 194
                       ||...::.....|..::.||.||.:.|..   ..:.::||..:.|.  .:||:|
  Rat    49 -----------FQTLIHLLKGNIGTGLLGLPLAVKNAGLLLGPLSLLVIGIVAVHCM--GILVKC 100

  Fly   195 LY---------------------EPDPATGQMVRVRDSYVAIAKVCFGPKLGARAVSIAQLIELL 238
            .:                     |..|:|  .:|....:            |.|.|....::..|
  Rat   101 AHHLCRRLNKPFLDYGDTVMYGLECSPST--WIRNHSHW------------GRRIVDFFLVVTQL 151

  Fly   239 MTCILYVVVCGDLLAGTYPQ---------------------GSFDSRSWMLFVGIFLLPMGFLKS 282
            ..|.:|.|    .||..:.|                     .:.|||.:||....||:.:.|:::
  Rat   152 GFCCVYFV----FLADNFKQVIEAANGTTTNCNNNETVILTPTMDSRLYMLTFLPFLVLLSFIRN 212

  Fly   283 LKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGWSKVRFSIDMENFPISLGVIVFSYTS-QIFL 346
            |:::|..|....:|..|...:|..:.:.:|.|  .|.:......:.:|:..|..:|::.. .:.|
  Rat   213 LRILSIFSLLANISMFVSLIMIYQFIVQRIPD--PSHLPLVAPWKTYPLFFGTAIFAFEGIGVVL 275

  Fly   347 PTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDTQQVITNNLHSQGFKGMVNFFLV 411
            | ||..|.|..||..:|........|.....|.:.:|.|..|.:..||.||.:......|.....
  Rat   276 P-LENKMKDSQKFPLILYLGMAIITVLYISLGSLGYLQFGADIKGSITLNLPNCWLYQSVKLLYS 339

  Fly   412 IKALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPH 476
            |....:|.|.:|.|.|::........|: :|..:.:|..         |..::..|.::|:.||.
  Rat   340 IGIFFTYALQFYVAAEIIIPAIVSRVPE-RFELVVDLSA---------RTAMVCVTCVLAVLIPR 394

  Fly   477 FSILMGFIGSFTGTMLSFIWPCYFHI-KIKGHLLDQKEIAKDYLIIGLGVLFGVIGIYDS 535
            ..:::..:||.:.:.|:.|.|....: ...|..:....|.||.||..||.:..|:|.|:|
  Rat   395 LDLVISLVGSVSSSALALIIPPLLEVTTYYGEGISPLTITKDALISILGFVGFVVGTYES 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	96/435 (22%)
Slc36a1	NP_569099.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32		8/46 (17%)
Slc36a1	NP_569099.1	SLC5-6-like_sbd	47..452	CDD:382020	96/449 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166352539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740