Protein Alignment VGAT and SLC38A9

DIOPT Version :9

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_001336311.1
• Gene: SLC38A9 / 153129
• HGNCID: 26907
• Length: 561
• Species: Homo sapiens
• Alignment Length: 502
• Identity: 94/502 - (18%)
• Similarity: 188/502 - (37%)
• Gaps: 127/502 - (25%)

  Fly   126 GSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVLHGGY---WAIVAMVGIAHI-CCY 186
            ||::..:....|..|.......:.:.|.:.|..|:|:|:.:...|:   ..::.::|:..: |||
Human   102 GSAYKLQSYTEGYGKNTSLVTIFMIWNTMMGTSILSIPWGIKQAGFTTGMCVIILMGLLTLYCCY 166

  Fly   187 TGKVLVQCLYEPDPATGQMVRVRDSYVAIAKVCFGPKLGARAVSIAQLIELLMTCILY------- 244
            ........::..|..:.:       |..:.:..|| ..|..:..:..|:.|:...|:|
Human   167 RVVKSRTMMFSLDTTSWE-------YPDVCRHYFG-SFGQWSSLLFSLVSLIGAMIVYWVLMSNF 223

  Fly   245 ----------------------------VVVCGDLLAGTYPQGS-------------FD-----S 263
                                        .|:|....:|.:|..|             |:     |
Human   224 LFNTGKFIFNFIHHINDTDTILSTNNSNPVICPSAGSGGHPDNSSMIFYANDTGAQQFEKWWDKS 288

  Fly   264 RSWMLFVGIFLLPM------GFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGW----- 317
            |:...::...|||:      .|.....::.|:|....:..:...||.||:.|    ::.|
Human   289 RTVPFYLVGLLLPLLNFKSPSFFSKFNILGTVSVLYLIFLVTFKAVRLGFHL----EFHWFIPTE 349

  Fly   318 ---SKVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGY 379
               .::||     .||...||:..::.....:.||..|  ::.:.|.:.|.. ||..:....:.|
Human   350 FFVPEIRF-----QFPQLTGVLTLAFFIHNCIITLLKN--NKKQENNVRDLC-IAYMLVTLTYLY 406

  Fly   380 ICFLTFQNDTQQVITNNLHSQGFKGMVNF------------FLVIKALLSYP-LPYYAACELLER 431
            |..|.|.:.....::.:...|.|  :.||            ||:.:.:..|| |.|.|..:||..
Human   407 IGVLVFASFPSPPLSKDCIEQNF--LDNFPSSDTLSFIARIFLLFQMMTVYPLLGYLARVQLLGH 469

  Fly   432 NFFRGPPKTKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIW 496
            .|     ...:|:|:::        |...:.::.:.::||.|.|:...::.:.|:..|....||:
Human   470 IF-----GDIYPSIFHV--------LILNLIIVGAGVIMACFYPNIGGIIRYSGAACGLAFVFIY 521

  Fly   497 PCYFHIKIKGHLLDQKEIAKDYLIIGLGVLFGVIGIYDSGNALINAF 543
            |...:| |..|  .::.:....||..:.::  ::|:   .|.::..|
Human   522 PSLIYI-ISLH--QEERLTWPKLIFHVFII--ILGV---ANLIVQFF 560

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	88/472 (19%)
SLC38A9	NP_001336311.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30
		SLC5-6-like_sbd	115..556	CDD:320982	90/483 (19%)
		Important for arginine binding and amino acid transport. /evidence=ECO:0000250|UniProtKB:Q08BA4	129..134		1/4 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900