Protein Alignment VGAT and SLC38A8

DIOPT Version :10

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_001073911.1
• Gene: SLC38A8 / 146167
• HGNCID: 32434
• Length: 435
• Species: Homo sapiens
• Alignment Length: 517
• Identity: 112/517 - (21%)
• Similarity: 186/517 - (35%)
• Gaps: 179/517 - (34%)

  Fly   113 QTDGFR-----------QGSIASEGSSFVCEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAV 166
            ||.|.|           ..:::|.|:.|:.. :...|..:..|..|::....:...|:|.|...|
Human     4 QTPGSRGLPEKPHPATAAATLSSMGAVFILM-KSALGAGLLNFPWAFSKAGGVVPAFLVELVSLV 67

  Fly   167 --LHG----GYWAIVAMVGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYVAIAKVCFGPKLG 225
              :.|    ||.|.|:  |.|   .|.|.|...|    .||.|:          :.:.||
Human    68 FLISGLVILGYAAAVS--GQA---TYQGVVRGLC----GPAIGK----------LCEACF----- 108

  Fly   226 ARAVSIAQLIELLMTCILYVVVCGD--------LLAGTYPQGS---FDSRSWMLFVGIF-LLPM- 277
                    |:.|||..:.::.|.||        ||:||.|...   .|.|..:..:.:. :||:
Human   109 --------LLNLLMISVAFLRVIGDQLEKLCDSLLSGTPPAPQPWYADQRFTLPLLSVLVILPLS 165

  Fly   278 -----GFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDW---------------GWSKVRF 322
                 .|.|...::.||:. |.::.:    :.:.|.|     |               .|:.| |
Human   166 APREIAFQKYTSILGTLAA-CYLALV----ITVQYYL-----WPQGLVRESHPSLSPASWTSV-F 219

  Fly   323 SIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWML--DWSHIAAAVFKAGFGYICFLTF 385
            |:    ||    .|.|.:.......::..:|..||..:|.|  ..|.:|..:..:..|...||||
Human   220 SV----FP----TICFGFQCHEAAVSIYCSMRKRSLSHWALVSVLSLLACCLIYSLTGVYGFLTF 276

  Fly   386 QNDTQQVITNNLHSQGFKGMVNFFLVIKALLS------YPLPYYAACELLERNFFR-------GP 437
            ..   :|..:.|.|.....||  .:|.:.|.:      ||:..:....::: :|:|       ||
Human   277 GT---EVSADVLMSYPGNDMV--IIVARVLFAVSIVTVYPIVLFLGRSVMQ-DFWRRSCLGGWGP 335

  Fly   438 PKTKFPTIWNLDGELKVWGLGFRVGV----IVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWP- 497
            .....|:           ||..|:.:    :..|:.||:|:|..|.::..||..:...: ||:|
Human   336 SALADPS-----------GLWVRMPLTILWVTVTLAMALFMPDLSEIVSIIGGISSFFI-FIFPG 388

  Fly   498 -CYFHIKIKGHLLDQKEIAKDYLIIGLGV------------LFGVIGIYDSGNALINAFEIG 546
             |                    ||..:||            ::||:.:      |:..|..|
Human   389 LC--------------------LICAMGVEPIGPRVKCCLEVWGVVSV------LVGTFIFG 424

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:444915	101/460 (22%)
SLC38A8	NP_001073911.1	SLC5-6-like_sbd	23..431	CDD:444915	108/498 (22%)