Protein Alignment VGAT and SLC32A1

DIOPT Version :10

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_542119.1
• Gene: SLC32A1 / 140679
• HGNCID: 11018
• Length: 525
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 217/470 - (46%)
• Similarity: 301/470 - (64%)
• Gaps: 26/470 - (5%)

  Fly    84 DGEGGGDGDGEYRNEYQSTSFNEYDGRYQQTDGFRQGSIASEGSSFVCEGEGGGG-------CKI 141
            :||..||...|        :..|.|..||:..|   ..:...||.   :..||||       .||
Human    66 EGEPCGDEGAE--------APVEGDIHYQRGSG---APLPPSGSK---DQVGGGGEFGGHDKPKI 116

  Fly   142 DEFQAAWNVTNAIQGMFIVSLPFAVLHGGYWAIVAMVGIAHICCYTGKVLVQCLYEPDPATGQMV 206
            ..::|.|||||||||||::.||:|:|||||..:..::..|.:||||||:|:.|||| :...|::|
Human   117 TAWEAGWNVTNAIQGMFVLGLPYAILHGGYLGLFLIIFAAVVCCYTGKILIACLYE-ENEDGEVV 180

  Fly   207 RVRDSYVAIAKVCFGPK---LGARAVSIAQLIELLMTCILYVVVCGDLLAGTYPQGSFDSRSWML 268
            ||||||||||..|..|:   ||.|.|::||:|||:|||||||||.|:|:..::|......:||.:
Human   181 RVRDSYVAIANACCAPRFPTLGGRVVNVAQIIELVMTCILYVVVSGNLMYNSFPGLPVSQKSWSI 245

  Fly   269 FVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDWGWSKVRFSIDMENFPISL 333
            .....|||..|||:||.||..|..||::|.|||.:::.|||.:..||.|.||:|.||::.||||:
Human   246 IATAVLLPCAFLKNLKAVSKFSLLCTLAHFVINILVIAYCLSRARDWAWEKVKFYIDVKKFPISI 310

  Fly   334 GVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAAVFKAGFGYICFLTFQNDTQQVITNNLH 398
            |:||||||||||||:|||||...|:|:.|::|:||||.|.|..|..:.:||:.::|::|||:||.
Human   311 GIIVFSYTSQIFLPSLEGNMQQPSEFHCMMNWTHIAACVLKGLFALVAYLTWADETKEVITDNLP 375

  Fly   399 SQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTIWNLDGELKVWGLGFRVGV 463
            . ..:.:||.|||.|||||||||::||.|:||::.|:...:..||..::.||.||.|||..|..:
Human   376 G-SIRAVVNIFLVAKALLSYPLPFFAAVEVLEKSLFQEGSRAFFPACYSGDGRLKSWGLTLRCAL 439

  Fly   464 IVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKIKGHLLDQKEIAKDYLIIGLGVLFG 528
            :|.|:||||::|||::|||..||.||..|.|:.|..||:::....|...::..|..|..:|.:..
Human   440 VVFTLLMAIYVPHFALLMGLTGSLTGAGLCFLLPSLFHLRLLWRKLLWHQVFFDVAIFVIGGICS 504

  Fly   529 VIGIYDSGNALINAF 543
            |.|...|...||.|:
Human   505 VSGFVHSLEGLIEAY 519

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:444915	195/391 (50%)
SLC32A1	NP_542119.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	83..107		8/29 (28%)
		Aa_trans	115..512	CDD:279788	197/398 (49%)