DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and SLC38A10

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	XP_011522590.1	Gene:	SLC38A10 / 124565	HGNCID:	28237	Length:	1134	Species:	Homo sapiens

Alignment Length:	421	Identity:	98/421 - (23%)
Similarity:	175/421 - (41%)	Gaps:	83/421 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 NVTNAIQGMFIVSLPFAVLHGGYWAIVAMVGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYV 213
            |:.|:|.|:.::::||.....|    :.:..:..:.| :......|::....|:   :..|.:|.
Human    14 NIVNSIVGVSVLTMPFCFKQCG----IVLGALLLVFC-SWMTHQSCMFLVKSAS---LSKRRTYA 70

  Fly   214 AIAKV-------CFGPKLGARAVSIAQLIELLMTCILYVVVCGDL-------LAGTYPQGSFDSR 264
            .:.:.       .:| |.|...|..:.:..:|.|||.:.||.|||       |.|....|:|  |
Human    71 GLGEAPSPQAFHAYG-KAGKMLVETSMIGLMLGTCIAFYVVIGDLGSNFFARLFGFQVGGTF--R 132

  Fly   265 SWMLF-VGI-FLLP-------MGFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDW--GWS 318
            .::|| |.: .:||       |..::|...::.|.:...|..||::::..|   |..|.|  ..|
Human   133 MFLLFAVSLCIVLPLSLQRNMMASIQSFSAMALLFYTVFMFVIVLSSLKHG---LFSGQWLRRVS 194

  Fly   319 KVRFSIDMENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAA------VFKAGF 377
            .||:.......|| .| :.|:..||: |||.:.  :|......|   |.|.|:      .|....
Human   195 YVRWEGVFRCIPI-FG-MSFACQSQV-LPTYDS--LDEPSVKTM---SSIFASSLNVVTTFYVMV 251

  Fly   378 GYICFLTFQNDTQQVITNNLHSQGFKGMVNFFLVIKALLSYP---LPYYAA-----CELLERN-- 432
            |:..:::|...|...:..:..|.....|:....::...:.:|   ||...|     ||..:::
Human   252 GFFGYVSFTEATAGNVLMHFPSNLVTEMLRVGFMMSVAVGFPMMILPCRQALSTLLCEQQQKDGT 316

  Fly   433 FFRG--PPKTKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFI 495
            |..|  .|..:|..:              .:.|:..|::..|.||:...::|..|:..|:::.||
Human   317 FAAGGYMPPLRFKAL--------------TLSVVFGTMVGGILIPNVETILGLTGATMGSLICFI 367

  Fly   496 WPCYFHIKIKGHLLDQKEIAKDYLIIGLGVL 526
            .|...:.||..:.|..:.:    |.:|||||
Human   368 CPALIYKKIHKNALSSQVV----LWVGLGVL 394

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	98/421 (23%)
SLC38A10	XP_011522590.1	SLC5-6-like_sbd	6..388	CDD:294310	92/413 (22%)
		SdaC	14..404	CDD:223884	98/421 (23%)
		BASP1	488..690	CDD:283191
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810