DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and SLC36A4

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	NP_689526.2	Gene:	SLC36A4 / 120103	HGNCID:	19660	Length:	504	Species:	Homo sapiens

Alignment Length:	512	Identity:	112/512 - (21%)
Similarity:	189/512 - (36%)	Gaps:	131/512 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    83 NDGEGGGDGDGEYRNEYQSTSFNEYDGRYQQTDGFRQGSIASEGSSFVCEGEGGGGCKIDEFQAA 147
            |:....|..|.|:..|....     ...||..|        .||.|||              |..
Human    28 NEQNFDGTSDEEHEQELLPV-----QKHYQLDD--------QEGISFV--------------QTL 65

  Fly   148 WNVTNAIQGMFIVSLPFAVLHGGYWAIV------AMVGIAHICCYTGKVLVQCLYEPDPATGQMV 206
            .::.....|..::.||.|:.:.|   ||      ..:||..:.|.  .:||:|.:      ...:
Human    66 MHLLKGNIGTGLLGLPLAIKNAG---IVLGPISLVFIGIISVHCM--HILVRCSH------FLCL 119

  Fly   207 RVRDSYVAIA-KVCFGPKL------------GARAVSIAQLIELLMTCILYVVVCGDLLAGTY-- 256
            |.:.|.:..: .|.|..::            |...|....:|..|..|.:|:|...:.:...:
Human   120 RFKKSTLGYSDTVSFAMEVSPWSCLQKQAAWGRSVVDFFLVITQLGFCSVYIVFLAENVKQVHEG 184

  Fly   257 ------------------PQGSFDSRSWMLFVGIFLLPMGFLKSLKMVSTLSFWCTMSHIVINAV 303
                              .:.|.|.|.:||....|::.:.|::.||.:..|||...:|..|...:
Human   185 FLESKVFISNSTNSSNPCERRSVDLRIYMLCFLPFIILLVFIRELKNLFVLSFLANVSMAVSLVI 249

  Fly   304 ILGYCLLQIGD-------WGWSKVRFSIDMENFPISLGVIVFSYTS-QIFLPTLEGNMIDRSKFN 360
            |..|.:..:.|       .||.|         :|:..|..||::.. .:.|| ||..|.:..:|.
Human   250 IYQYVVRNMPDPHNLPIVAGWKK---------YPLFFGTAVFAFEGIGVVLP-LENQMKESKRFP 304

  Fly   361 WMLD-WSHIAAAVF--KAGFGYICFLTFQNDTQQVITNNLHS-----QGFKGMVNFFLVIKALLS 417
            ..|: ...|...::  .|..||:|   |.::.:..||.||..     |..|.:.:|.:.:    :
Human   305 QALNIGMGIVTTLYVTLATLGYMC---FHDEIKGSITLNLPQDVWLYQSVKILYSFGIFV----T 362

  Fly   418 YPLPYYAACELLERNFFRGPPKTKFPTIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMG 482
            |.:.:|...|::....     .:||.|.|.     ::...|.|..::..|...||.||...|::.
Human   363 YSIQFYVPAEIIIPGI-----TSKFHTKWK-----QICEFGIRSFLVSITCAGAILIPRLDIVIS 417

  Fly   483 FIGSFTGTMLSFIWPCYFHIKIKGHLLDQKE------IAKDYLIIGLGVLFGVIGIY 533
            |:|:.:.:.|:.|.|....|     |...||      :.|:..|...||:..::|.|
Human   418 FVGAVSSSTLALILPPLVEI-----LTFSKEHYNIWMVLKNISIAFTGVVGFLLGTY 469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	98/449 (22%)
SLC36A4	NP_689526.2	SLC5-6-like_sbd	58..476	CDD:294310	103/469 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165158534
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740