Protein Alignment VGAT and SLC38A3

DIOPT Version :9

• Sequence 1: NP_610938.1
• Gene: VGAT / 36574
• FlyBaseID: FBgn0033911
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_006832.1
• Gene: SLC38A3 / 10991
• HGNCID: 18044
• Length: 504
• Species: Homo sapiens
• Alignment Length: 478
• Identity: 97/478 - (20%)
• Similarity: 191/478 - (39%)
• Gaps: 114/478 - (23%)

  Fly   125 EGSSFV------------CEGEGGGGCKIDEFQAAWNVTNAIQGMFIVSLPFAVLHGG-YWAIVA 176
            ||.||:            .||:...|..:      :|::|||.|..|:.|.:|:.:.| ...:..
Human    44 EGKSFLQKSPSKEPHFTDFEGKTSFGMSV------FNLSNAIMGSGILGLAYAMANTGIILFLFL 102

  Fly   177 MVGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYVAIAKVCFGPKLGARAVSIAQLIELL--M 239
            :..:|.:..|:..:|::        :..:|.:| :|..:....||.. |..|.::|..::.:  |
Human   103 LTAVALLSSYSIHLLLK--------SSGVVGIR-AYEQLGYRAFGTP-GKLAAALAITLQNIGAM 157

  Fly   240 TCILYVVVCG-DLLAGTYPQGSFDSRSW-------MLFVGI-FLLPMGFLKSLKMV---STLSFW 292
            :..||::... .|:..|:......:..|       ::.|.: .:||:..::.|..:   |..|..
Human   158 SSYLYIIKSELPLVIQTFLNLEEKTSDWYMNGNYLVILVSVTIILPLALMRQLGYLGYSSGFSLS 222

  Fly   293 CTMSHIVINAVILGY------CLL------QIGDWGW-----SKVRFSIDME------------- 327
            |.:..::  |||  |      |.|      ..|::..     .||:..::.|
Human   223 CMVFFLI--AVI--YKKFHVPCPLPPNFNNTTGNFSHVEIVKEKVQLQVEPEASAFCTPSYFTLN 283

  Fly   328 -NFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWMLDWSHIAAAV------FKAGFGYICFLTF 385
             ....::.::.|::.....:..:...:.|.|| ..|...|:::.||      ..|.|||   |||
Human   284 SQTAYTIPIMAFAFVCHPEVLPIYTELKDPSK-KKMQHISNLSIAVMYIMYFLAALFGY---LTF 344

  Fly   386 QNDTQQVITNNLHSQG----FKGM---VNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFP 443
            .|..:..:   ||:..    |..:   |...::....|:.|:..:.....:::..|   |..:|.
Human   345 YNGVESEL---LHTYSKVDPFDVLILCVRVAVLTAVTLTVPIVLFPVRRAIQQMLF---PNQEFS 403

  Fly   444 TIWNLDGELKVWGLGFRVGVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKIKGHL 508
            .:.:         :...||::....|:.||.|:...:.|.||:.:...|.||:|..|:.:|   :
Human   404 WLRH---------VLIAVGLLTCINLLVIFAPNILGIFGVIGATSAPFLIFIFPAIFYFRI---M 456

  Fly   509 LDQKEIAKDYLIIGLGVLFGVIG 531
            ..:||.|:....| |.:.|.::|
Human   457 PTEKEPARSTPKI-LALCFAMLG 478

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	90/447 (20%)
SLC38A3	NP_006832.1	Aa_trans	64..491	CDD:279788	92/458 (20%)
		SdaC	64..486	CDD:223884	92/458 (20%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0814
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810