DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment VGAT and slc38a10

DIOPT Version :9

Sequence 1:	NP_610938.1	Gene:	VGAT / 36574	FlyBaseID:	FBgn0033911	Length:	549	Species:	Drosophila melanogaster
Sequence 2:	XP_004916417.2	Gene:	slc38a10 / 100488480	XenbaseID:	XB-GENE-958197	Length:	1066	Species:	Xenopus tropicalis

Alignment Length:	419	Identity:	101/419 - (24%)
Similarity:	169/419 - (40%)	Gaps:	74/419 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   149 NVTNAIQGMFIVSLPFAVLHGGYWAIVAMVGIAHICCYTGKVLVQCLYEPDPATGQMVRVRDSYV 213
            |:.|:|.|:.::::||.....|   |:....:..:|.:  .....|::....|:   |..|.:|.
Frog    11 NIVNSIVGVSVLTMPFCFKQCG---IILGTLLLMLCAW--MTHQSCMFLVKSAS---VSKRRTYA 67

  Fly   214 AIAKVCFGPKLGARAVSIAQLIELLMTCILYVVVCGDL-------LAGTYPQGSFDSRSWMLF-V 270
            .:|...:| |.|...|..:.:..:|.|||.:.||.|||       |.|......|  |.::|| |
Frog    68 GLAFNAYG-KAGKMMVETSMIGLMLGTCIAFYVVIGDLGSSFFARLLGLQVTEGF--RVFLLFSV 129

  Fly   271 GI-FLLP-------MGFLKSLKMVSTLSFWCTMSHIVINAVILGYCLLQIGDW--GWSKVRFSID 325
            .: .:||       |..::|...::.:.:...|..||:::...|   |..|.|  ..|.||:...
Frog   130 SLCIVLPLSLQRNMMASIQSFSAMALMFYTVFMFVIVLSSFKHG---LFSGQWLKHVSYVRWEGV 191

  Fly   326 MENFPISLGVIVFSYTSQIFLPTLEGNMIDRSKFNWM-----LDWSHIAAAVFKAG-FGYICFLT 384
            ....|| .| :.|:..||: |||.:.  :|......|     |..:.:.......| |||:.|
Frog   192 FRCIPI-YG-MSFACQSQV-LPTYDS--LDEPSVKIMSSIFALSLNVVTTFYITVGFFGYVSF-- 249

  Fly   385 FQNDTQQVITN---NLHSQGFKGMVNFFLVIKALLSYPLPYYAACELLERNFFRGPPKTKFPTIW 446
                |:.:..|   |..|.....|:....::...:.:|:......:.|....|....|
Frog   250 ----TESIAGNVLVNFPSNLVTEMIRVGFMMSVAVGFPMMILPCRQALNTLLFEQQQK------- 303

  Fly   447 NLDGELKVWG----LGFRV---GVIVSTILMAIFIPHFSILMGFIGSFTGTMLSFIWPCYFHIKI 504
              ||.....|    |.|:|   .|:..|:|..|.||:...::|..|:..|:::..|.|...:.||
Frog   304 --DGTFTAGGYMPPLRFKVLTLVVVFGTMLGGILIPNVETILGLTGATMGSLICLICPALIYKKI 366

  Fly   505 KGHLLDQKEIAKDYLIIGLGVLFGVIGIY 533
                  .|:......|:|:|::..||..|
Frog   367 ------HKKGLTSQFILGVGLVILVISTY 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
VGAT	NP_610938.1	SLC5-6-like_sbd	144..533	CDD:382020	100/417 (24%)
slc38a10	XP_004916417.2	SLC5-6-like_sbd	3..393	CDD:382020	101/419 (24%)
slc38a10	XP_004916417.2	PTZ00121	<396..1013	CDD:173412
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910