DRSC/TRiP Functional Genomics Resources

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Protein Alignment cg and ZNF646

DIOPT Version :9

Sequence 1:NP_001097306.2 Gene:cg / 36571 FlyBaseID:FBgn0000289 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_055514.3 Gene:ZNF646 / 9726 HGNCID:29004 Length:1832 Species:Homo sapiens


Alignment Length:944 Identity:217/944 - (22%)
Similarity:328/944 - (34%) Gaps:280/944 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 GYTWGFADNGNRAAESVLEISPNINYTVSGESMPYLLSTDGSL-AVQKDVKGLTAGGKNNVVRRM 74
            |.|.|..:.|..  |.|.|.:|       ..|.|..||....| .:|::|:.|.:.|..::....
Human   908 GMTEGSEEEGEE--EGVAEAAP-------ARSPPLQLSEAELLNQLQREVEALDSAGYGHICGCC 963

  Fly    75 FVVNDPSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPA--TAAAAAAAAGGD---- 133
            ....|..  ...:|...:..:.|...|..:...|.. |...::||..  ....:.:..|||    
Human   964 GQTYDDL--GSLERHHQSQSSGTTADKAPSPLGVAG-DAMEMVVDSVLEDIVNSVSGEGGDAKSQ 1025

  Fly   134 ----SGLAHHHTLTNG-SIVDA--------KTGQTVLTAGSAAAKSHFSSIGALHLTQE----EC 181
                :.|.....:..| |:::|        :.|:|....||..  :|    ..:|.|.:    .|
Human  1026 EGAGTPLGDSLCIQGGESLLEAQPRPFRCNQCGKTYRHGGSLV--NH----RKIHQTGDFLCPVC 1084

  Fly   182 NEILIKRAIAAGHHQTHTITAADGSHHHASGGTPSFCSVGGATTLLGDILPGISVQVQKVIQGLE 246
            :......|....|.:.|  ....||.... |..|.  :.|.:...:|.|..|.|.:.|.:.    
Human  1085 SRCYPNLAAYRNHLRNH--PRCKGSEPQV-GPIPE--AAGSSELQVGPIPEGGSNKPQHMA---- 1140

  Fly   247 DNEDSQGEA------PNLKLEP------------------GTLELSPKTELQESMHFSETDATIK 287
              |:..|:|      ..||:||                  |. |:.|:.|..|.  ..:|:|:  
Human  1141 --EEGPGQAEVEKLQEELKVEPLEEVARVKEEVWEETTVKGE-EIEPRLETAEK--GCQTEAS-- 1198

  Fly   288 KERPYSCDECGKSFLLKH------HLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTER 346
            .|||:||:.||:|:  ||      |..:|...|.|     |..|.|.|::...|..|..:|:..|
Human  1199 SERPFSCEVCGRSY--KHAGSLINHRQSHQTGHFG-----CQACSKGFSNLMSLKNHRRIHADPR 1256

  Fly   347 PYQCQECKKSFTLKHHLLTHSRVH------------SRE-RPFVCQECGRAFPLKRHLVTHSKFH 398
            .::|.||.|:|.|:..|.:|.|||            :|| |||.|.:|||.:.....|:.|.:.|
Human  1257 RFRCSECGKAFRLRKQLASHQRVHMERRGGGGTRKATREDRPFRCGQCGRTYRHAGSLLNHRRSH 1321

  Fly   399 -AGERPYVCEECGESFAQENHLIMHSRFHG---------SLNPFV-CAECGASFPRKFQLVNHGR 452
             .|:  |.|..|.::::....|..|.|.|.         |....| ||.||.|||.:..|..|.|
Human  1322 ETGQ--YSCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRTAVRCALCGRSFPGRGSLERHLR 1384

  Fly   453 IH---------------GKIPHSCTVCGKEFLQKR----TLVSHMR--------------RVHTG 484
            .|               |.......:.|.:.|:.:    ..|.|:.              |..:.
Human  1385 EHEETEREPANGQGGLDGTAASEANLTGSQGLETQLGGAEPVPHLEDGVPRPGERSQSPIRAASS 1449

  Fly   485 EQAHPCVSCGEG---------------------FLTKAELHQ---HVRTAHNG---VN-PNTSSA 521
            |...| :|.|.|                     |||::|..:   |....|.|   :| |..|..
Human  1450 EAPEP-LSWGAGKAGGWPVGGGLGNHSGGWVPQFLTRSEEPEDSVHRSPCHAGDCQLNGPTLSHM 1513

  Fly   522 TIIANQ----QLQQAHHHQAGQ--QTHPQTITVVSNPGNST------------LLTVSTT--DAN 566
            ....|:    |||...|....|  :|:.|:.:::::..|.|            |..|:|.  ..|
Human  1514 DSWDNRDNSSQLQPGSHSSCSQCGKTYCQSGSLLNHNTNKTDRHYCLLCSKEFLNPVATKSHSHN 1578

  Fly   567 GVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTAN 631
            .:....|.|.:||.||.|.:.||.||:.|..                                  
Human  1579 HIDAQTFACPDCGKAFESHQELASHLQAHAR---------------------------------- 1609

  Fly   632 PNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQ 696
                |.|.||.|:         :......|.:...|.|      :|..|:.|.......:...:.
Human  1610 ----GHSQVPAQM---------EEARDPKAGTGEDQVV------LPGQGKAQEAPSETPRGPGES 1655

  Fly   697 QQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNG--GCTV------------ 747
            .::.:..|.|.|:|..:|.:...|..||:.:.....|:.|.:.|..|  .|::            
Human  1656 VERARGGQAVTSMAAEDKERPFRCTQCGRSYRHAGSLLNHQKAHTTGLYPCSLCPKLLPNLLSLK 1720

  Fly   748 ---RTHV------CE-CGKAFFQKNHLMLHQRQH 771
               |||.      |. |||||.....|..|.|.|
Human  1721 NHSRTHTDPKRHCCSICGKAFRTAARLEGHGRVH 1754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cgNP_001097306.2 COG5048 287..>371 CDD:227381 33/101 (33%)
C2H2 Zn finger 294..314 CDD:275368 8/25 (32%)
zf-H2C2_2 306..331 CDD:290200 8/24 (33%)
C2H2 Zn finger 322..342 CDD:275368 6/19 (32%)
C2H2 Zn finger 350..370 CDD:275368 9/19 (47%)
zf-H2C2_2 362..385 CDD:290200 14/35 (40%)
C2H2 Zn finger 378..398 CDD:275368 6/19 (32%)
zf-H2C2_2 390..415 CDD:290200 7/25 (28%)
C2H2 Zn finger 406..426 CDD:275368 5/19 (26%)
SIR2 <425..>465 CDD:294129 15/64 (23%)
C2H2 Zn finger 434..454 CDD:275368 10/19 (53%)
C2H2 Zn finger 461..482 CDD:275368 5/38 (13%)
C2H2 Zn finger 490..509 CDD:275368 8/42 (19%)
lambda-1 491..>603 CDD:212564 39/159 (25%)
C2H2 Zn finger 575..595 CDD:275368 10/19 (53%)
C2H2 Zn finger 720..740 CDD:275368 5/19 (26%)
C2H2 Zn finger 752..771 CDD:275368 9/19 (47%)
ZNF646NP_055514.3 C2H2 Zn finger 10..31 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..47
C2H2 Zn finger 50..70 CDD:275368
zf-C2H2 75..97 CDD:333835
C2H2 Zn finger 77..97 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 94..200
C2H2 Zn finger 241..261 CDD:275368
C2H2 Zn finger 268..288 CDD:275368
C2H2 Zn finger 296..316 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..346
C2H2 Zn finger 376..396 CDD:275368
C2H2 Zn finger 403..423 CDD:275368
C2H2 Zn finger 467..487 CDD:275368
C2H2 Zn finger 494..514 CDD:275368
C2H2 Zn finger 577..597 CDD:275368
C2H2 Zn finger 619..639 CDD:275368
C2H2 Zn finger 646..663 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..810
C2H2 Zn finger 823..843 CDD:275368
C2H2 Zn finger 850..870 CDD:275368
C2H2 Zn finger 883..901 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 901..931 8/31 (26%)
C2H2 Zn finger 1054..1074 CDD:275368 5/25 (20%)
C2H2 Zn finger 1081..1101 CDD:275368 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1148 12/53 (23%)
C2H2 Zn finger 1205..1225 CDD:275368 7/21 (33%)
C2H2 Zn finger 1232..1252 CDD:275368 6/19 (32%)
C2H2 Zn finger 1260..1280 CDD:275368 9/19 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1294 4/19 (21%)
C2H2 Zn finger 1301..1321 CDD:275368 6/19 (32%)
C2H2 Zn finger 1328..1348 CDD:275368 5/19 (26%)
C2H2 Zn finger 1366..1386 CDD:275368 10/19 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1377..1481 15/104 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1509..1529 5/19 (26%)
C2H2 Zn finger 1533..1552 CDD:275368 3/18 (17%)
C2H2 Zn finger 1559..1579 CDD:275368 3/19 (16%)
C2H2 Zn finger 1587..1611 CDD:275368 11/61 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1606..1672 16/118 (14%)
C2H2 Zn finger 1679..1699 CDD:275368 5/19 (26%)
C2H2 Zn finger 1706..1726 CDD:275368 2/19 (11%)
zf-H2C2_2 1718..1743 CDD:372612 9/24 (38%)
C2H2 Zn finger 1734..1754 CDD:275368 9/19 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1781..1832
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24388
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
11.100

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