DRSC/TRiP Functional Genomics Resources

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Protein Alignment cg and ZNF646

DIOPT Version :10

Sequence 1:NP_001097306.2 Gene:cg / 36571 FlyBaseID:FBgn0000289 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_055514.3 Gene:ZNF646 / 9726 HGNCID:29004 Length:1832 Species:Homo sapiens


Alignment Length:937 Identity:215/937 - (22%)
Similarity:328/937 - (35%) Gaps:266/937 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    11 GYTWGFADNGNRAAESVLEISPNINYTVSGESMPYLLSTDGSL-AVQKDVKGLTAGGKNNVVRRM 74
            |.|.|..:.|..  |.|.|.:|       ..|.|..||....| .:|::|:.|.:.|..::....
Human   908 GMTEGSEEEGEE--EGVAEAAP-------ARSPPLQLSEAELLNQLQREVEALDSAGYGHICGCC 963

  Fly    75 FVVNDPSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPA--TAAAAAAAAGGDSGLA 137
            ....|..  ...:|...:..:.|...|..:...|.. |...::||..  ....:.:..|||:...
Human   964 GQTYDDL--GSLERHHQSQSSGTTADKAPSPLGVAG-DAMEMVVDSVLEDIVNSVSGEGGDAKSQ 1025

  Fly   138 HHHTLTNGSIVDAKTGQTVLTAG------SAAAKS--HFSSI---GALHLTQE----ECNEILIK 187
            .......|..:..:.|:::|.|.      :...|:  |..|:   ..:|.|.:    .|:.....
Human  1026 EGAGTPLGDSLCIQGGESLLEAQPRPFRCNQCGKTYRHGGSLVNHRKIHQTGDFLCPVCSRCYPN 1090

  Fly   188 RAIAAGHHQTHTITAADGSHHHASGGTPSFCSVGGATTLLGDILPGISVQVQKVIQGLEDNEDSQ 252
            .|....|.:.|  ....||.... |..|.  :.|.:...:|.|..|.|.:.|.:.      |:..
Human  1091 LAAYRNHLRNH--PRCKGSEPQV-GPIPE--AAGSSELQVGPIPEGGSNKPQHMA------EEGP 1144

  Fly   253 GEA------PNLKLEP--------------GTL---ELSPKTELQESMHFSETDATIKKERPYSC 294
            |:|      ..||:||              .|:   |:.|:.|..|.  ..:|:|:  .|||:||
Human  1145 GQAEVEKLQEELKVEPLEEVARVKEEVWEETTVKGEEIEPRLETAEK--GCQTEAS--SERPFSC 1205

  Fly   295 DECGKSFLLKH------HLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQEC 353
            :.||:|:  ||      |..:|...|.|     |..|.|.|::...|..|..:|:..|.::|.||
Human  1206 EVCGRSY--KHAGSLINHRQSHQTGHFG-----CQACSKGFSNLMSLKNHRRIHADPRRFRCSEC 1263

  Fly   354 KKSFTLKHHLLTHSRVH------------SRE-RPFVCQECGRAFPLKRHLVTHSKFH-AGERPY 404
            .|:|.|:..|.:|.|||            :|| |||.|.:|||.:.....|:.|.:.| .|:  |
Human  1264 GKAFRLRKQLASHQRVHMERRGGGGTRKATREDRPFRCGQCGRTYRHAGSLLNHRRSHETGQ--Y 1326

  Fly   405 VCEECGESFAQENHLIMHSRFHG---------SLNPFV-CAECGASFPRKFQLVNHGRIH----- 454
            .|..|.::::....|..|.|.|.         |....| ||.||.|||.:..|..|.|.|     
Human  1327 SCPTCPKTYSNRMALKDHQRLHSENRRRRAGRSRRTAVRCALCGRSFPGRGSLERHLREHEETER 1391

  Fly   455 ----------GKIPHSCTVCGKEFLQKR----TLVSHMR--------------RVHTGEQAHPCV 491
                      |.......:.|.:.|:.:    ..|.|:.              |..:.|...| :
Human  1392 EPANGQGGLDGTAASEANLTGSQGLETQLGGAEPVPHLEDGVPRPGERSQSPIRAASSEAPEP-L 1455

  Fly   492 SCGEG---------------------FLTKAELHQ---HVRTAHNG---VN-PNTSSATIIANQ- 527
            |.|.|                     |||::|..:   |....|.|   :| |..|......|: 
Human  1456 SWGAGKAGGWPVGGGLGNHSGGWVPQFLTRSEEPEDSVHRSPCHAGDCQLNGPTLSHMDSWDNRD 1520

  Fly   528 ---QLQQAHHHQAGQ--QTHPQTITVVSNPGNST------------LLTVSTT--DANGVARPQF 573
               |||...|....|  :|:.|:.:::::..|.|            |..|:|.  ..|.:....|
Human  1521 NSSQLQPGSHSSCSQCGKTYCQSGSLLNHNTNKTDRHYCLLCSKEFLNPVATKSHSHNHIDAQTF 1585

  Fly   574 VCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQS 638
            .|.:||.||.|.:.||.||:.|..                                      |.|
Human  1586 ACPDCGKAFESHQELASHLQAHAR--------------------------------------GHS 1612

  Fly   639 PVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQ 703
            .||.|:         :......|.:...|.|      :|..|:.|.......:...:..::.:..
Human  1613 QVPAQM---------EEARDPKAGTGEDQVV------LPGQGKAQEAPSETPRGPGESVERARGG 1662

  Fly   704 QHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNG--GCTV---------------RTHV 751
            |.|.|:|..:|.:...|..||:.:.....|:.|.:.|..|  .|::               |||.
Human  1663 QAVTSMAAEDKERPFRCTQCGRSYRHAGSLLNHQKAHTTGLYPCSLCPKLLPNLLSLKNHSRTHT 1727

  Fly   752 ------CE-CGKAFFQKNHLMLHQRQH 771
                  |. |||||.....|..|.|.|
Human  1728 DPKRHCCSICGKAFRTAARLEGHGRVH 1754

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cgNP_001097306.2 COG5048 287..>371 CDD:227381 33/101 (33%)
C2H2 Zn finger 294..314 CDD:275368 8/25 (32%)
zf-H2C2_2 306..331 CDD:463886 8/24 (33%)
C2H2 Zn finger 322..342 CDD:275368 6/19 (32%)
C2H2 Zn finger 350..370 CDD:275368 9/19 (47%)
C2H2 Zn finger 378..398 CDD:275368 6/19 (32%)
C2H2 Zn finger 406..426 CDD:275368 5/19 (26%)
C2H2 Zn finger 434..454 CDD:275368 10/19 (53%)
C2H2 Zn finger 461..482 CDD:275368 5/38 (13%)
C2H2 Zn finger 490..509 CDD:275368 8/42 (19%)
C2H2 Zn finger 575..595 CDD:275368 10/19 (53%)
C2H2 Zn finger 720..740 CDD:275368 5/19 (26%)
C2H2 Zn finger 752..771 CDD:275368 9/19 (47%)
ZNF646NP_055514.3 C2H2 Zn finger 10..31 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 26..47
C2H2 Zn finger 50..70 CDD:275368
zf-C2H2 75..97 CDD:395048
C2H2 Zn finger 77..97 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 94..200
C2H2 Zn finger 241..261 CDD:275368
C2H2 Zn finger 268..288 CDD:275368
C2H2 Zn finger 296..316 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 313..346
C2H2 Zn finger 376..396 CDD:275368
C2H2 Zn finger 403..423 CDD:275368
C2H2 Zn finger 467..487 CDD:275368
C2H2 Zn finger 494..514 CDD:275368
C2H2 Zn finger 577..597 CDD:275368
C2H2 Zn finger 619..639 CDD:275368
C2H2 Zn finger 646..663 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 660..810
C2H2 Zn finger 823..843 CDD:275368
C2H2 Zn finger 850..870 CDD:275368
C2H2 Zn finger 883..901 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 901..931 8/31 (26%)
C2H2 Zn finger 1054..1074 CDD:275368 3/19 (16%)
C2H2 Zn finger 1081..1101 CDD:275368 3/19 (16%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1103..1148 12/53 (23%)
C2H2 Zn finger 1205..1225 CDD:275368 7/21 (33%)
C2H2 Zn finger 1232..1252 CDD:275368 6/19 (32%)
C2H2 Zn finger 1260..1280 CDD:275368 9/19 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1274..1294 4/19 (21%)
C2H2 Zn finger 1301..1321 CDD:275368 6/19 (32%)
C2H2 Zn finger 1328..1348 CDD:275368 5/19 (26%)
C2H2 Zn finger 1366..1386 CDD:275368 10/19 (53%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1377..1481 15/104 (14%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1509..1529 5/19 (26%)
C2H2 Zn finger 1533..1552 CDD:275368 3/18 (17%)
C2H2 Zn finger 1559..1579 CDD:275368 3/19 (16%)
C2H2 Zn finger 1587..1611 CDD:275368 11/61 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1606..1672 16/118 (14%)
C2H2 Zn finger 1679..1699 CDD:275368 5/19 (26%)
C2H2 Zn finger 1706..1726 CDD:275368 2/19 (11%)
C2H2 Zn finger 1734..1754 CDD:275368 9/19 (47%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1781..1832
Blue background indicates that the domain is not in the aligned region.

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