DRSC/TRiP Functional Genomics Resources

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Protein Alignment cg and ZNF628

DIOPT Version :9

Sequence 1:NP_001097306.2 Gene:cg / 36571 FlyBaseID:FBgn0000289 Length:837 Species:Drosophila melanogaster
Sequence 2:NP_149104.3 Gene:ZNF628 / 89887 HGNCID:28054 Length:1059 Species:Homo sapiens


Alignment Length:653 Identity:159/653 - (24%)
Similarity:214/653 - (32%) Gaps:235/653 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly   292 YSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKS 356
            |.|.||||||.....|..|.|.||||||:.|..|.|:|.....|..|...|:.||||||.:|.|:
Human    36 YECGECGKSFRWSSRLLHHQRTHTGERPYKCPDCPKAFKGSSALLYHQRGHTGERPYQCPDCPKA 100

  Fly   357 FTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIM 421
            |.....|..|..||:..|.|:|.:||.||....|...|.:.|.|||||.|.:|.::|...:.|..
Human   101 FKRSSLLQIHRSVHTGLRAFICGQCGLAFKWSSHYQYHLRQHTGERPYPCPDCPKAFKNSSSLRR 165

  Fly   422 HSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMR------ 479
            |...|....|:.|..||.||.:...|..|.|:| |:.|..|.:|.|.|.....|:.|.|      
Human   166 HRHVHTGERPYTCGVCGKSFTQSTNLRQHQRVHTGERPFRCPLCPKTFTHSSNLLLHQRTHGAAP 230

  Fly   480 ------------------------------RVHT------------------------------- 483
                                          :.|:                               
Human   231 APGTASAAPPPQSREPGKVFVCDAYLQRHLQPHSPPAPPAPPPPPPPVVPELFLAAAETTVELVY 295

  Fly   484 ----------------------GEQAHP----------------------------------CVS 492
                                  |..|.|                                  |:.
Human   296 RCDGCEQGFSSEELLLEHQPCPGPDAAPQPQEAPAEAPKADQPPSPLPQPPPPAAAPAPGFACLP 360

  Fly   493 CGEGFLTKAEL--HQHVRTAHNGVNPNTSS--------ATIIANQQ--LQQA------HHHQAGQ 539
            ||:.|.|.|.|  |||...|..|......|        |:::|:||  :::|      ...:|.:
Human   361 CGKSFRTVAGLSRHQHSHGAAGGQAFRCGSCDGSFPQLASLLAHQQCHVEEAAAGRPPPQAEAAE 425

  Fly   540 QTHPQTITVVSNP-------------------------GNSTLLTVSTTDANGVARPQFVCRECG 579
            .|.||.....:.|                         ..|:.|.....|..| .|| :.|.|||
Human   426 VTCPQEPLAPAAPVPPPPPSAPASAERPYKCAECGKSFKGSSGLRYHLRDHTG-ERP-YQCGECG 488

  Fly   580 SAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQI 644
            .||.....||:|.|:|||.::.....|.||.....|:.....|:.|    ..|...|:       
Human   489 KAFKRSSLLAIHQRVHTGLRAFTCGQCGLTFKWSSHYQYHLRLHSG----ERPYACGE------- 542

  Fly   645 ISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSV 709
               .|:....|:.::                     :.:|: |..:                   
Human   543 ---CGKAFRNTSCLR---------------------RHRHV-HTGE------------------- 563

  Fly   710 APANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCE-CGKAFFQKNHLMLHQRQHLE 773
                  :.|.|..|||.||....|.||.|.|..    .|...|. |.|.|...::|:||||.|..
Human   564 ------RPHACGVCGKSFAQTSNLRQHQRVHTG----ERPFRCPLCPKTFTHSSNLLLHQRTHSA 618

  Fly   774 TKP 776
            .:|
Human   619 ERP 621

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
cgNP_001097306.2 COG5048 287..>371 CDD:227381 36/78 (46%)
C2H2 Zn finger 294..314 CDD:275368 10/19 (53%)
zf-H2C2_2 306..331 CDD:290200 13/24 (54%)
C2H2 Zn finger 322..342 CDD:275368 6/19 (32%)
C2H2 Zn finger 350..370 CDD:275368 6/19 (32%)
zf-H2C2_2 362..385 CDD:290200 9/22 (41%)
C2H2 Zn finger 378..398 CDD:275368 7/19 (37%)
zf-H2C2_2 390..415 CDD:290200 11/24 (46%)
C2H2 Zn finger 406..426 CDD:275368 5/19 (26%)
SIR2 <425..>465 CDD:294129 14/40 (35%)
C2H2 Zn finger 434..454 CDD:275368 8/19 (42%)
C2H2 Zn finger 461..482 CDD:275368 7/56 (13%)
C2H2 Zn finger 490..509 CDD:275368 10/20 (50%)
lambda-1 491..>603 CDD:212564 41/154 (27%)
C2H2 Zn finger 575..595 CDD:275368 10/19 (53%)
C2H2 Zn finger 720..740 CDD:275368 10/19 (53%)
C2H2 Zn finger 752..771 CDD:275368 9/19 (47%)
ZNF628NP_149104.3 C2H2 Zn finger 38..58 CDD:275368 10/19 (53%)
COG5048 <43..213 CDD:227381 68/169 (40%)
C2H2 Zn finger 66..86 CDD:275368 6/19 (32%)
C2H2 Zn finger 94..114 CDD:275368 6/19 (32%)
C2H2 Zn finger 122..142 CDD:275368 7/19 (37%)
C2H2 Zn finger 150..170 CDD:275368 5/19 (26%)
C2H2 Zn finger 178..198 CDD:275368 8/19 (42%)
zf-C2H2 204..226 CDD:306579 7/21 (33%)
C2H2 Zn finger 206..226 CDD:275368 7/19 (37%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 226..247 0/20 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 260..280 1/19 (5%)
C2H2 Zn finger 297..314 CDD:275368 0/16 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 312..351 3/38 (8%)
C2H2 Zn finger 361..378 CDD:275370 9/16 (56%)
C2H2 Zn finger 388..408 CDD:275368 5/19 (26%)
COG5048 <453..642 CDD:227381 55/236 (23%)
C2H2 Zn finger 456..476 CDD:275368 2/19 (11%)
C2H2 Zn finger 484..504 CDD:275368 10/19 (53%)
C2H2 Zn finger 512..532 CDD:275368 4/19 (21%)
C2H2 Zn finger 540..560 CDD:275368 4/51 (8%)
C2H2 Zn finger 568..588 CDD:275368 10/19 (53%)
C2H2 Zn finger 596..616 CDD:275368 9/19 (47%)
C2H2 Zn finger 624..644 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 644..674
4 X approximate tandem repeats. /evidence=ECO:0000250|UniProtKB:Q8CJ78 818..864
Interaction with TAF4B. /evidence=ECO:0000250|UniProtKB:Q8CJ78 943..1059
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

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