DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and ZNF341

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001269862.1	Gene:	ZNF341 / 84905	HGNCID:	15992	Length:	854	Species:	Homo sapiens

Alignment Length:	753	Identity:	168/753 - (22%)
Similarity:	250/753 - (33%)	Gaps:	227/753 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QNPPPFGYTWGFADNGNRAAESVLEISPNINYTVSGESMPYLLSTDGSLAVQKDVKGLTAGGKNN 69
            |.|||...:.|.....|.....|:|:     |:.:..     |:..|::.:|  ..|:.......
Human   195 QPPPPPPQSLGPPGRPNPGGNGVVEV-----YSAAAP-----LAGSGTVEIQ--ALGMQPYPPLE 247

  Fly    70 VVRRMFVVNDPSFP------PGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAAA 128
            |..:  .|..|.:|      ||.|.....|                          |..||...:
Human   248 VPNQ--CVEPPVYPTPTVYSPGKQGFKPKG--------------------------PNPAAPMTS 284

  Fly   129 AAGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFSSIG---ALHLTQEECNEILIK--- 187
            |.|             |::....:..|:.|..:..|:....:.|   |..|....|::...|
Human   285 ATG-------------GTVATFDSPATLKTRRAKGARGLPEAAGKPKAQKLKCSYCDKSFTKNFD 336

  Fly   188 --------------RAIAAG-----------HHQTHTITAADGSHHHASGGTPSFCSV------- 220
                          :.||.|           |.|||.:...  .|   ||||.|..||
Human   337 LQQHIRSHTGEKPFQCIACGRAFAQKSNVKKHMQTHKVWPP--GH---SGGTVSRNSVTVQVMAL 396

  Fly   221 ------GGATTLLGDILPGISVQVQKVIQGLEDNEDSQGEAPNLK----LEPGTL-ELSP---KT 271
                  ...:|.||..|||....     |.|....:.:|:.|..|    ::...| :..|   .|
Human   397 NPSRQEDEESTGLGQPLPGAPQP-----QALSTAGEEEGDKPESKQVVLIDSSYLCQFCPSKFST 456

  Fly   272 ELQESMHFSETDATIKKERPYSC--DECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHC 334
            ..|...|.::.    |.|:.|.|  ..|.::|........|.:.|..|..:.|..|||.|...:.
Human   457 YFQLKSHMTQH----KNEQVYKCVVKSCAQTFPKLDTFLEHIKSHQEELSYRCHLCGKDFPSLYD 517

  Fly   335 LNTHLLLHS---------TERPYQCQECKKSFT----LKHHLLTHSRVHSRERPFVCQECGRAFP 386
            |..|...||         ....|:|.:|...::    |:|||.|  ..|:    |.|..|.:.||
Human   518 LGVHQYSHSLLPQHSPKKDNAVYKCVKCVNKYSTPEALEHHLQT--ATHN----FPCPHCQKVFP 576

  Fly   387 LKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHG 451
            .:|:|..|...|.....:.|:.|.:.|.:|::|.:|:..|....|:.|:.|.::|.||.:|..|.
Human   577 CERYLRRHLPTHGSGGRFKCQVCKKFFRREHYLKLHAHIHSGEKPYKCSVCESAFNRKDKLKRHM 641

  Fly   452 RIHG-----KIPHSC-TVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTA 510
            .||.     |.|.|. |.|.|||.:...|.:|:.. |:|.:.|.|..|.:.|..:|.|.:|.| |
Human   642 LIHEPFKKYKCPFSTHTGCSKEFNRPDKLKAHILS-HSGMKLHKCALCSKSFSRRAHLAEHQR-A 704

  Fly   511 HNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVC 575
            |.|                                                        ..:|.|
Human   705 HTG--------------------------------------------------------NYKFRC 713

  Fly   576 RECGSAFNSREALALHLRLHTG---DKSLMTDLCALTAALPGHFLSTASLNPG--TVVTANPNLV 635
            ..|...|:..:.|..| |...|   ||.|.|.......|.|      .|...|  .|:|..|:
Human   714 AGCAKGFSRHKYLKDH-RCRLGPQKDKDLQTRRPPQRRAAP------RSCGSGGRKVLTPLPD-- 769

  Fly   636 GQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAV 673
               |:.::.:..||..:....:........|.||::.|
Human   770 ---PLGLEELKDTGAGLVPEAVPGKPPFAEPDAVLSIV 804

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	26/98 (27%)
		C2H2 Zn finger	294..314	CDD:275368	4/21 (19%)
		zf-H2C2_2	306..331	CDD:290200	8/24 (33%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	7/23 (30%)
		zf-H2C2_2	362..385	CDD:290200	7/22 (32%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	6/24 (25%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		SIR2	<425..>465	CDD:294129	15/45 (33%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..482	CDD:275368	7/21 (33%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	20/114 (18%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
ZNF341	NP_001269862.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	152..217		6/21 (29%)
		COG5048	323..729	CDD:227381	114/483 (24%)
		C2H2 Zn finger	324..344	CDD:275368	2/19 (11%)
		C2H2 Zn finger	352..372	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	399..434		9/39 (23%)
		C2H2 Zn finger	447..467	CDD:275368	4/19 (21%)
		C2H2 Zn finger	475..497	CDD:275368	4/21 (19%)
		C2H2 Zn finger	505..525	CDD:275368	7/19 (37%)
		C2H2 Zn finger	542..562	CDD:275370	7/21 (33%)
		C2H2 Zn finger	568..588	CDD:275368	7/19 (37%)
		C2H2 Zn finger	596..616	CDD:275368	6/19 (32%)
		C2H2 Zn finger	624..644	CDD:275368	7/19 (37%)
		C2H2 Zn finger	652..677	CDD:275368	9/25 (36%)
		C2H2 Zn finger	685..705	CDD:275368	7/20 (35%)
		C2H2 Zn finger	713..730	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	731..763		9/37 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100