Protein Alignment cg and ZNF93

DIOPT Version :10

• Sequence 1: NP_001097306.2
• Gene: cg / 36571
• FlyBaseID: FBgn0000289
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_112495.2
• Gene: ZNF93 / 81931
• HGNCID: 13169
• Length: 620
• Species: Homo sapiens
• Alignment Length: 511
• Identity: 146/511 - (28%)
• Similarity: 236/511 - (46%)
• Gaps: 81/511 - (15%)

  Fly   288 KERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQE 352
            :::|:.|.||||:|.....|.||.::||||:|:||..|||:|.:...||||..:|:.|:||:|.:
Human   169 EKKPFKCIECGKAFNQFSTLITHKKIHTGEKPYICEECGKAFKYSSALNTHKRIHTGEKPYKCDK 233

  Fly   353 CKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQEN 417
            |.|:|.....|..|..:|:.::|:.|:|||:||.....|..|.|.|.||:||.|||||::|.|.:
Human   234 CDKAFIASSTLSKHEIIHTGKKPYKCEECGKAFNQSSTLTKHKKIHTGEKPYKCEECGKAFNQSS 298

  Fly   418 HLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMRRV 481
            .|..|.:.|....|:||.|||.:|.....|..|.||| |:.|:.|..|||.|:...||..| ..:
Human   299 TLTKHKKIHTGEKPYVCEECGKAFKYSRILTTHKRIHTGEKPYKCNKCGKAFIASSTLSRH-EFI 362

  Fly   482 HTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTI 546
            |.|::.:.|..||:.|:..:.|.:|.| .|.|..|...       ::..:|..:.:...:|.::.
Human   363 HMGKKHYKCEECGKAFIWSSVLTRHKR-VHTGEKPYKC-------EECGKAFKYSSTLSSHKRSH 419

  Fly   547 T--------------VVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTG 597
            |              |.|:       |:|..:.....:..:.|.|||.|||...:|..|.::|||
Human   420 TGEKPYKCEECGKAFVASS-------TLSKHEIIHTGKKPYKCEECGKAFNQSSSLTKHKKIHTG 477

  Fly   598 DKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNL-VGQSPVPVQIISSTGQVMSQTTLVQAA 661
            :|....:.|.            .:.|..:.:|.:..: .|:.|...:   ..|:..:|::
Human   478 EKPYKCEECG------------KAFNQSSSLTKHKKIHTGEKPYKCE---ECGKAFNQSS----- 522

  Fly   662 NSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANK-----PKSHFCA 721
                     |.:....:|          .:::..:.::..:..|:.:....:|     .|.:.|.
Human   523 ---------TLIKHKKIH----------TREKPYKCEECGKAFHLSTHLTTHKILHTGEKPYRCR 568

  Fly   722 SCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCE-CGKAFFQKNHLMLHQRQHLETKP 776
            .|||.|.....|..|.:.|..    .:.:.|: |||||...:.|..|:..|...||
Human   569 ECGKAFNHSATLSSHKKIHSG----EKPYECDKCGKAFISPSSLSRHEIIHTGEKP 620

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	35/82 (43%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:463886	14/24 (58%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		C2H2 Zn finger	575..595	CDD:275368	9/19 (47%)
		C2H2 Zn finger	720..740	CDD:275368	7/19 (37%)
		C2H2 Zn finger	752..771	CDD:275368	8/19 (42%)
ZNF93	NP_112495.2	KRAB	4..62	CDD:214630
		C2H2 Zn finger	147..167	CDD:275368
		COG5048	170..612	CDD:227381	142/500 (28%)
		C2H2 Zn finger	175..195	CDD:275368	9/19 (47%)
		C2H2 Zn finger	203..223	CDD:275368	9/19 (47%)
		C2H2 Zn finger	231..251	CDD:275368	6/19 (32%)
		C2H2 Zn finger	259..279	CDD:275368	9/19 (47%)
		C2H2 Zn finger	287..307	CDD:275368	9/19 (47%)
		C2H2 Zn finger	315..335	CDD:275368	8/19 (42%)
		C2H2 Zn finger	343..363	CDD:275368	8/20 (40%)
		C2H2 Zn finger	371..391	CDD:275368	7/20 (35%)
		C2H2 Zn finger	399..419	CDD:275368	2/26 (8%)
		C2H2 Zn finger	427..447	CDD:275368	4/26 (15%)
		C2H2 Zn finger	455..475	CDD:275368	9/19 (47%)
		C2H2 Zn finger	483..503	CDD:275368	3/31 (10%)
		C2H2 Zn finger	511..531	CDD:275368	3/36 (8%)
		C2H2 Zn finger	539..559	CDD:275368	2/19 (11%)
		C2H2 Zn finger	567..587	CDD:275368	7/19 (37%)
		C2H2 Zn finger	595..615	CDD:275368	8/19 (42%)