DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and zbtb4

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_001339146.2	Gene:	zbtb4 / 798710	ZFINID:	ZDB-GENE-100318-5	Length:	1570	Species:	Danio rerio

Alignment Length:	698	Identity:	150/698 - (21%)
Similarity:	254/698 - (36%)	Gaps:	180/698 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   223 ATTLLGDILPGISVQVQKVIQGLEDNEDSQG---EAPNLKLE---------------------PG 263
            :||....||..:|.:..: .||::|.|:|:|   :|.:|.:|                     |.
Zfish   153 STTETAHILFNLSARAYQ-DQGVKDPENSKGKKRKANSLHVELSLPLPSINPHSSSSTPPPHSPS 216

  Fly   264 TLEL--SPKTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCG 326
            ::.|  ||.|....|.|.| ..|..|.|  ..|..|.:.|.....||.|.|:|.|.|...|.|||
Zfish   217 SVSLTSSPLTHPTASFHDS-FRAVPKPE--LLCGVCHRLFSTASSLTVHMRLHRGGRVLSCRHCG 278

  Fly   327 KSFAHKHCLNTHLLLHSTERPYQCQECKKSFTL--KHHLLTHSRV------HSRERPFVCQECGR 383
            |:|.|...|.:|   .:|     |::...:|.:  |...|....|      .:.|...:.||...
Zfish   279 KAFIHNKRLQSH---EAT-----CRQGLPAFPVPPKEEPLEEGEVEGERTDEAAEPEQLGQETRP 335

  Fly   384 AFPLK--RHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQ 446
            ..|.|  |.|...   ||     ....||::...::|.:.....|   ..:.|:.|..|:.....
Zfish   336 GQPAKKVRDLTAR---HA-----EALTCGDTLGDDDHFVKVVDGH---IIYFCSVCERSYMTLSS 389

  Fly   447 LVNHGRIHG---KIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVR 508
            |..|..:|.   |.|  |..|.|.|........| ...||||:.:.|:.|.|.|.|...|..|.:
Zfish   390 LKRHSNVHSWRRKYP--CHFCDKVFALAEYRTKH-EVWHTGERRYQCIFCWEAFPTYYNLKTHQK 451

  Fly   509 TAHNGVNPNTSSATIIANQQLQQ-----AHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTD---- 564
            ..| |:||...|:...||...:|     ..:.....::..:.....|.|....|||..:||
Zfish   452 AFH-GINPGLISSEKTANGGYKQKVNALKLYRLLPMRSLKRPYKTYSQPMADGLLTSDSTDNLHL 515

  Fly   565 -ANGVARPQFVCRECGSAF----------NSREALALHLRLHTGDK--SLMTDLCALTAALPGHF 616
             .:| :.||.:..:...:|          ...|...:.|.:..|.:  |..||:     .|....
Zfish   516 SVDG-SLPQPLDTKKLESFLKDLQNQDIKAETEGFPIRLDIEQGTEIASPQTDM-----TLEAGQ 574

  Fly   617 LSTASLNPGTVVTANPNLVGQSP-VPVQIISSTGQVMSQTTLVQAANSTHPQAVV--TAVPTMPV 678
            :..:.|.|    :.|.|..||:| .|.:.:||          |.|...:.|..::  |||.:..:
Zfish   575 VEDSDLWP----SGNNNDKGQTPKCPERAVSS----------VIAFARSKPSVIMHSTAVSSSVI 625

  Fly   679 HGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNG 743
                     |.:.:...:::::..::|.::..                      :.:|:::.|.
Zfish   626 ---------VHRNKTDSEERKRSPEKHQLAKT----------------------IKKHSQKEPT- 658

  Fly   744 GCTVRTHVCECGKAFFQKNHL--------------MLHQRQHLETKPAISQQQEAATQQQLATAG 794
                        :|:.:.|.:              .||:.:.:..|...|:....|...::..:|
Zfish   659 ------------EAYREWNAVGLDPEVSKIRHPTEKLHKGRKVHHKTESSKTIPLAVGSEVKGSG 711

  Fly   795 EQQQVQVQIMPDGQIHGKVIKYEICRNVMP-----------EDQQQEQ 831
            ...|:.|:|..:..:...:.:.::.|:..|           :|:|:||
Zfish   712 PLCQITVRIGEEAIVKRSISETDLRRDKSPTRSKPKKSNLLQDKQREQ 759

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	27/91 (30%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		zf-H2C2_2	306..331	CDD:290200	13/24 (54%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	5/27 (19%)
		zf-H2C2_2	362..385	CDD:290200	5/28 (18%)
		C2H2 Zn finger	378..398	CDD:275368	6/21 (29%)
		zf-H2C2_2	390..415	CDD:290200	5/24 (21%)
		C2H2 Zn finger	406..426	CDD:275368	3/19 (16%)
		SIR2	<425..>465	CDD:294129	10/42 (24%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	461..482	CDD:275368	5/20 (25%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	29/133 (22%)
		C2H2 Zn finger	575..595	CDD:275368	3/29 (10%)
		C2H2 Zn finger	720..740	CDD:275368	1/19 (5%)
		C2H2 Zn finger	752..771	CDD:275368	4/32 (13%)
zbtb4	XP_001339146.2	C2H2 Zn finger	246..266	CDD:275368	7/19 (37%)
		C2H2 Zn finger	274..290	CDD:275368	8/15 (53%)
		C2H2 Zn finger	377..397	CDD:275368	5/19 (26%)
		C2H2 Zn finger	405..425	CDD:275368	5/20 (25%)
		C2H2 Zn finger	433..451	CDD:275368	7/17 (41%)
		PTZ00121	<630..946	CDD:173412	20/165 (12%)
		C2H2 Zn finger	955..975	CDD:275368
		C2H2 Zn finger	981..1002	CDD:275368
		C2H2 Zn finger	1056..1076	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100