DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and ZNF142

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001353219.1	Gene:	ZNF142 / 7701	HGNCID:	12927	Length:	1887	Species:	Homo sapiens

Alignment Length:	702	Identity:	156/702 - (22%)
Similarity:	234/702 - (33%)	Gaps:	189/702 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   165 KSHFSSIGA----LHLTQEECNEILIKRAIAAGH-HQTHTITAADGSHHHASGGTPSFCSVGGAT 224
            |||.::..|    |...||.|:.....|.....| .:||.:.|.:..||.        |.:..||
Human   473 KSHTAAAAAEPLPLRCFQEGCSYAAPDRKAFIKHLKETHGVRAVECRHHS--------CPMLFAT 529

  Fly   225 TLLGDILPGISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKE 289
                                                          .|..|:.|        |..
Human   530 ----------------------------------------------AEAMEAHH--------KSH 540

  Fly   290 RPYSCDEC-----GKSFLLKHHLTTH-------------------------ARVHTGERPHICTH 324
            ..:.|..|     .|....||....|                         .::|..|:.|.|..
Human   541 YAFHCPHCDFACSNKHLFRKHKKQGHPGSEELRCTFCPFATFNPVAYQDHVGKMHAHEKIHQCPE 605

  Fly   325 CGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFT------LKHHLLTHSRVHSRERPFVCQECGR 383
            |..:.|||..|..|:|||:.|:|::|:.|  .||      |..|:||||..    :.::|.|||.
Human   606 CNFATAHKRVLIRHMLLHTGEKPHKCELC--DFTCRDVSYLSKHMLTHSNT----KDYMCTECGY 664

  Fly   384 AFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLV 448
            ....|.:|..|.:.|||:..|.|.:|.....:.:.|..|...|.. ...:|..|..:..||::|.
Human   665 VTKWKHYLRVHMRKHAGDLRYQCNQCSYRCHRADQLSSHKLRHQG-KSLMCEVCAFACKRKYELQ 728

  Fly   449 NH--GRIHGKIP---HSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVR 508
            .|  .:.|...|   :.|..|..:...|:.::||....||..:...|..|.....:...|..|.|
Human   729 KHMASQHHPGTPAPLYPCHYCSYQSRHKQAVLSHENCKHTRLREFHCALCDYRTFSNTTLLFHKR 793

  Fly   509 TAHNGVNPNTSSATIIANQQLQQAHH----------------------HQAGQQTHP---QTITV 548
            .||..|..:.:.....|:|:.:.|..                      |:.|....|   |.:..
Human   794 KAHGYVPGDQAWQLRYASQEPEGAMQGPTPPPDSEPSNQLSARPEGPGHEPGTVVDPSLDQALPE 858

  Fly   549 VSNPGNSTLLTVSTT----DANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALT 609
            :|...|:.....|..    |..|...|..|  |.||.....|||.:.|...|     ...|..:|
Human   859 MSEEVNTGRQEGSEAPHGGDLGGSPSPAEV--EEGSCTLHLEALGVELESVT-----EPPLEEVT 916

  Fly   610 AALPGHFLSTASLNP--------------GTV-VTANPNLVGQSPVPVQIISSTGQVMSQTTLVQ 659
            ...|..|.......|              ||. ::|..|.:.:.||..   .||    :..:|.:
Human   917 ETAPMEFRPLGLEGPDGLEGPELSSFEGIGTSDLSAEENPLLEKPVSE---PST----NPPSLEE 974

  Fly   660 AANS------THPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSH 718
            |.|:      |.|.|....:|.:|   :.:.|....::|.::|.:....:..|..|....:.::.
Human   975 APNNWVGTFKTTPPAETAPLPPLP---ESESLLKALRRQDKEQAEALVLEGRVQMVVIQGEGRAF 1036

  Fly   719 FCASCGKGFAAKHGLMQHNRRHPNGGCTVRTH--VC-ECGKAFFQKNHLMLH 767
            .|..|......:..|..|:|.    ||..|..  :| |||.:|.|:..|..|
Human  1037 RCPHCPFITRREKALNLHSRT----GCQGRREPLLCPECGASFKQQRGLSTH 1084

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	32/119 (27%)
		C2H2 Zn finger	294..314	CDD:275368	6/49 (12%)
		zf-H2C2_2	306..331	CDD:290200	6/49 (12%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	10/25 (40%)
		zf-H2C2_2	362..385	CDD:290200	9/22 (41%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	8/24 (33%)
		C2H2 Zn finger	406..426	CDD:275368	4/19 (21%)
		SIR2	<425..>465	CDD:294129	10/44 (23%)
		C2H2 Zn finger	434..454	CDD:275368	6/21 (29%)
		C2H2 Zn finger	461..482	CDD:275368	5/20 (25%)
		C2H2 Zn finger	490..509	CDD:275368	4/18 (22%)
		lambda-1	491..>603	CDD:212564	29/140 (21%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368	5/19 (26%)
		C2H2 Zn finger	752..771	CDD:275368	8/17 (47%)
ZNF142	NP_001353219.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23
		C2H2 Zn finger	365..385	CDD:275368
		C2H2 Zn finger	393..413	CDD:275368
		C2H2 Zn finger	421..438	CDD:275368
		C2H2 Zn finger	455..475	CDD:275368	1/1 (100%)
		C2H2 Zn finger	545..566	CDD:275368	5/20 (25%)
		C2H2 Zn finger	574..595	CDD:275368	0/20 (0%)
		zf-H2C2_5	601..625	CDD:404746	11/23 (48%)
		C2H2 Zn finger	603..623	CDD:275368	8/19 (42%)
		C2H2 Zn finger	631..651	CDD:275368	7/21 (33%)
		C2H2 Zn finger	659..679	CDD:275368	7/19 (37%)
		C2H2 Zn finger	687..707	CDD:275368	4/19 (21%)
		C2H2 Zn finger	714..731	CDD:275368	5/16 (31%)
		PHA03247	928..>1219	CDD:223021	38/171 (22%)
		C2H2 Zn finger	1306..1353	CDD:275368
		C2H2 Zn finger	1373..1394	CDD:275368
		C2H2 Zn finger	1402..1422	CDD:275368
		C2H2 Zn finger	1430..1451	CDD:275368
		C2H2 Zn finger	1626..1646	CDD:275368
		C2H2 Zn finger	1654..1674	CDD:275368
		C2H2 Zn finger	1682..1702	CDD:275368
		C2H2 Zn finger	1710..1730	CDD:275368
		zf-H2C2_2	1723..1747	CDD:404364
		C2H2 Zn finger	1738..1759	CDD:275368
		C2H2 Zn finger	1767..1787	CDD:275368
		C2H2 Zn finger	1795..1815	CDD:275368
		C2H2 Zn finger	1823..1843	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000