DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and ZNF221

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001284517.1	Gene:	ZNF221 / 7638	HGNCID:	13014	Length:	617	Species:	Homo sapiens

Alignment Length:	611	Identity:	161/611 - (26%)
Similarity:	233/611 - (38%)	Gaps:	194/611 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 HLTQE-----ECNEILIKRAIAAGHHQTHTITAADGSHHHASGGT-PSFCSVGGATTLLGDILPG 233
            |:.|:     ||.:.....::...|.|:|:     |...|..|.. .|||
Human   164 HVQQKPYRCNECKQSFSDVSVFDLHQQSHS-----GEKSHTCGECGKSFC--------------- 208

  Fly   234 ISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECG 298
                                             .||...:.:.:|..        |:.|.||.||
Human   209 ---------------------------------YSPALHIHQRVHMG--------EKCYKCDVCG 232

  Fly   299 KSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHL 363
            |.|....||.||.||||||:|..|..|||.|..:..||.|..||:.|:||.|:||.|:|.....|
Human   233 KEFNQSSHLQTHQRVHTGEKPFKCGQCGKGFHSRSALNVHCKLHTGEKPYNCEECGKAFIHDSQL 297

  Fly   364 LTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGS 428
            ..|.|:|:.|:||.|..||::|.::..|..||..|.||:|:.|:.||::|.|.:.|..||..|..
Human   298 QEHQRIHTGEKPFKCDICGKSFRVRSRLNRHSMVHTGEKPFRCDTCGKNFRQRSALNSHSMVHIE 362

  Fly   429 LNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVS 492
            ..|:.|.:||..|..:.....|..:| |:.|::|..|||.|.....|::| ::||:|:::..|..
Human   363 EKPYKCEQCGKGFICRRDFCKHQMVHTGEKPYNCKECGKTFRWSSCLLNH-QQVHSGQKSFKCEE 426

  Fly   493 CGEGFLTKAELHQHVRTAHNGVNP-NTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNST 556
            ||:||.|.:....|.| :|||..| |.........::|....|    |:.|..
Human   427 CGKGFYTNSRRSSHQR-SHNGEKPYNCEECGKDYKRRLDLEFH----QRVHTG------------ 474

  Fly   557 LLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTAS 621
                        .|| :.|:|||.:|.....|..|.|||:|:|....:.|
Human   475 ------------ERP-YNCKECGKSFGWASCLLKHQRLHSGEKPFKCEEC--------------- 511

  Fly   622 LNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQ 686
                                       |:..:|::.:.:..:.|.             |:
Human   512 ---------------------------GKRFTQSSQLHSHQTCHT-------------GE----- 531

  Fly   687 HVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHV 751
                                         |.:.|..|.||:.:|..|..|.|.|  ||  .|.:.
Human   532 -----------------------------KLYKCEQCEKGYNSKFNLDMHQRVH--GG--ERPYN 563

  Fly   752 C-ECGKAFFQKNHLMLHQRQHLETKP 776
            | ||||:|...:.|:.|||.|...||
Human   564 CKECGKSFGWASCLLKHQRLHSGEKP 589

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	40/83 (48%)
		C2H2 Zn finger	294..314	CDD:275368	11/19 (58%)
		zf-H2C2_2	306..331	CDD:290200	16/24 (67%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		zf-H2C2_2	362..385	CDD:290200	10/22 (45%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	11/24 (46%)
		C2H2 Zn finger	406..426	CDD:275368	8/19 (42%)
		SIR2	<425..>465	CDD:294129	11/40 (28%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	461..482	CDD:275368	7/20 (35%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	30/112 (27%)
		C2H2 Zn finger	575..595	CDD:275368	8/19 (42%)
		C2H2 Zn finger	720..740	CDD:275368	8/19 (42%)
		C2H2 Zn finger	752..771	CDD:275368	10/19 (53%)
ZNF221	NP_001284517.1	KRAB	30..70	CDD:307490
		COG5048	166..576	CDD:227381	153/594 (26%)
		C2H2 Zn finger	172..192	CDD:275368	4/19 (21%)
		C2H2 Zn finger	200..220	CDD:275368	6/67 (9%)
		C2H2 Zn finger	228..248	CDD:275368	11/19 (58%)
		C2H2 Zn finger	256..276	CDD:275368	8/19 (42%)
		C2H2 Zn finger	284..304	CDD:275368	8/19 (42%)
		C2H2 Zn finger	312..332	CDD:275368	7/19 (37%)
		C2H2 Zn finger	340..360	CDD:275368	8/19 (42%)
		C2H2 Zn finger	368..388	CDD:275368	5/19 (26%)
		C2H2 Zn finger	396..416	CDD:275368	7/20 (35%)
		C2H2 Zn finger	424..444	CDD:275368	8/20 (40%)
		C2H2 Zn finger	452..472	CDD:275368	3/23 (13%)
		C2H2 Zn finger	480..500	CDD:275368	8/19 (42%)
		C2H2 Zn finger	508..528	CDD:275368	3/61 (5%)
		C2H2 Zn finger	536..556	CDD:275368	8/19 (42%)
		C2H2 Zn finger	564..584	CDD:275368	10/19 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100