Protein Alignment cg and ZNF33B

DIOPT Version :10

• Sequence 1: NP_001097306.2
• Gene: cg / 36571
• FlyBaseID: FBgn0000289
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001291962.1
• Gene: ZNF33B / 7582
• HGNCID: 13097
• Length: 785
• Species: Homo sapiens
• Alignment Length: 538
• Identity: 167/538 - (31%)
• Similarity: 226/538 - (42%)
• Gaps: 127/538 - (23%)

  Fly   287 KKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQ 351
            |.|:.:.|:||||:|..|.|||.|.||||||:...|..|||:|..|..|..|...|:.|:|::|.
Human   331 KGEKHFECNECGKAFWEKSHLTRHQRVHTGEKHFQCNQCGKTFWEKSNLTKHQRSHTGEKPFECN 395

  Fly   352 ECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQE 416
            ||.|:|:.|..|..|.|.|:.|:|:.|..||:.|..|..|..|.:.|.|::||.|.|||:||...
Human   396 ECGKAFSHKSALTLHQRTHTGEKPYQCNACGKTFYQKSDLTKHQRTHTGQKPYECYECGKSFCMN 460

  Fly   417 NHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMRR 480
            :||.:|.|.|....||.|.|||.||.:|..|..|.|.| |..|:.|..|||.|..|..|..| :.
Human   461 SHLTVHQRTHTGEKPFECLECGKSFCQKSHLTQHQRTHIGDKPYECNACGKTFYHKSVLTRH-QI 524

  Fly   481 VHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQT 545
            :|||.:.:.|..||:.|..|::|..|.|| |.|..|       .|..:..:...|::....|.:|
Human   525 IHTGLKPYECYECGKTFCLKSDLTIHQRT-HTGEKP-------FACPECGKFFSHKSTLSQHYRT 581

  Fly   546 ITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTA 610
            .|                     ....:.|.|||..|.::..|..|.|.|||:|....:.|..|
Human   582 HT---------------------GEKPYECHECGKIFYNKSYLTKHNRTHTGEKPYECNECGKT- 624

  Fly   611 ALPGHFLSTASLNPGTVVTANPNL-VGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVP 674
                 |...:.|      |.:..: :|:.|..   .:..|:..           .|..|::
Human   625 -----FCQKSQL------TQHQRIHIGEKPYE---CNECGKAF-----------CHKSALI---- 660

  Fly   675 TMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRR 739
               || |:.|.|.                            |.:.|..|||.|..|.||:.|.|:
Human   661 ---VH-QRTHTQE----------------------------KPYKCNECGKSFCVKSGLILHERK 693

  Fly   740 HP----------------NGGCTV--RTHV------C-ECGKAFFQKNHLMLHQRQHLETKP--- 776
            |.                ....||  |.|.      | ||||.|::|:.|..|||.|...||
Human   694 HTGEKPYECNECGKSFSHKSSLTVHHRAHTGEKSCQCNECGKIFYRKSDLAKHQRSHTGEKPYEC 758

  Fly   777 -----AISQQQEAATQQQ 789
                 ..||:......|:
Human   759 NTCRKTFSQKSNLIVHQR 776

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	39/83 (47%)
		C2H2 Zn finger	294..314	CDD:275368	12/19 (63%)
		zf-H2C2_2	306..331	CDD:463886	15/24 (63%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	10/19 (53%)
		C2H2 Zn finger	434..454	CDD:275368	10/19 (53%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		C2H2 Zn finger	575..595	CDD:275368	8/19 (42%)
		C2H2 Zn finger	720..740	CDD:275368	10/19 (53%)
		C2H2 Zn finger	752..771	CDD:275368	11/19 (58%)
ZNF33B	NP_001291962.1	KRAB	19..78	CDD:214630
		C2H2 Zn finger	310..330	CDD:275368
		C2H2 Zn finger	338..358	CDD:275368	12/19 (63%)
		zf-H2C2_2	350..374	CDD:463886	14/23 (61%)
		C2H2 Zn finger	366..386	CDD:275368	8/19 (42%)
		COG5048	390..779	CDD:227381	138/479 (29%)
		C2H2 Zn finger	394..414	CDD:275368	9/19 (47%)
		C2H2 Zn finger	422..442	CDD:275368	7/19 (37%)
		C2H2 Zn finger	450..470	CDD:275368	10/19 (53%)
		C2H2 Zn finger	478..498	CDD:275368	10/19 (53%)
		C2H2 Zn finger	506..526	CDD:275368	8/20 (40%)
		C2H2 Zn finger	534..554	CDD:275368	9/20 (45%)
		C2H2 Zn finger	562..582	CDD:275368	2/19 (11%)
		C2H2 Zn finger	590..610	CDD:275368	8/19 (42%)
		C2H2 Zn finger	618..638	CDD:275368	5/31 (16%)
		C2H2 Zn finger	646..666	CDD:275368	6/38 (16%)
		C2H2 Zn finger	674..694	CDD:275368	10/19 (53%)
		C2H2 Zn finger	702..722	CDD:275368	3/19 (16%)
		C2H2 Zn finger	730..750	CDD:275368	11/19 (58%)
		C2H2 Zn finger	758..778	CDD:275368	3/19 (16%)