DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and Zbtb4

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001350107.1	Gene:	Zbtb4 / 75580	MGIID:	1922830	Length:	982	Species:	Mus musculus

Alignment Length:	956	Identity:	176/956 - (18%)
Similarity:	279/956 - (29%)	Gaps:	356/956 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    77 VNDPSFPPGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHHT 141
            |.|||..|             .|..|.|.|::..|..:..|:           ||.....||...
Mouse     7 VTDPSHAP-------------AVLHQLNEQRLRGLFCDVTLI-----------AGDTKFPAHRSV 47

  Fly   142 LTNGS-------IVDAKTGQTVLTAGSAAAKSHFSSIGALHLTQEECNEILIKRAIAAGHHQTHT 199
            |...|       :..|......:|.|||.:.:                                |
Mouse    48 LAASSPFFREALLASAPLPLPPVTGGSAPSPA--------------------------------T 80

  Fly   200 ITAADGSHH-------HASG--------GTP--SFCSV-----------------GGATTLLGDI 230
            .|||..|..       |:|.        |.|  :|..|                 |.|...:|.:
Mouse    81 TTAASSSSSSPPPASPHSSSPPRVLELPGVPAAAFSDVLNFIYSARLALPGGGGDGAAVAEIGAL 145

  Fly   231 LPGISVQVQKVIQGL------------------EDNEDSQGEAPNL-------KLEPGTLELSPK 270
              |..:.:.: :|||                  :..||..|..|..       |.|..|.:..|:
Mouse   146 --GRRLGISR-LQGLGEGGDTWVPPAPTSMVTSDPTEDGLGAGPRTDGEWVGDKAEALTPDSQPR 207

  Fly   271 TELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTH---------ARVHTGERPHICTHCG 326
                               ||:.|..|||||:....|.||         .|...|..|.:....|
Mouse   208 -------------------RPFPCPRCGKSFIHPKRLQTHEAQCRRGSNTRGSAGLGPGVSGSGG 253

  Fly   327 KSFAHKHCL-----------------NTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRER 374
            .:......|                 ..|:|       |.|..|::|:.....|..||.|||..|
Mouse   254 PAGVDASALPQPVGFRDGPEHVVKVVGGHVL-------YVCAACERSYVTLSSLKRHSNVHSWRR 311

  Fly   375 PFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSR-FHGSLNPFVCAE-- 436
            .:.|:.|.:.|.|..:...|..:|.|||.|.|..|.::|....:|..|.| ||| ::|.:.|.
Mouse   312 KYPCRYCEKVFALAEYRTKHEVWHTGERRYQCIFCWDTFVTYYNLKTHQRAFHG-ISPGLLASEK 375

  Fly   437 --CGASFPRKFQLVNHGRIHGKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLT 499
              .|...||    :|..:::..:|               :.:..|...|..|..|
Mouse   376 TPNGGYKPR----LNTLKLYRLLP---------------MRAAKRPYKTYSQGAP---------- 411

  Fly   500 KAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTD 564
            :|.|...:.|        .:.|.:.|:.|.......:.|.   |.::...::|..|.::..|::.
Mouse   412 EAPLSPSLHT--------PAPAAMPASPQPLPPPAPEPGP---PPSVITFAHPAPSVIVHGSSSS 465

  Fly   565 ANGVARPQFVCRECGSAFNSREALALHLR-----------------LHTGDKSLMTDLCALTAAL 612
            ......|      .|:..:...::..:..                 ..|......|.:...|||.
Mouse   466 GAAGGGP------AGTGGSQAASVITYTTPPRPPKKREYPPPPPEPTATPTSPASTAVSPATAAG 524

  Fly   613 PGHFLSTA---SLNPGTVV--TANP--NLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVV 670
            |......|   :|..|..:  ||.|  .|.|....|......:.|:.:...|.|.......:|:|
Mouse   525 PATATEEAKGRNLRAGRTLTYTAKPVGGLSGSGGSPTGTGRGSSQLQAPPPLCQITVRIGEEAIV 589

  Fly   671 ------TAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHV----------------------- 706
                  |.:....:.|::.......:::::::.|::|::...
Mouse   590 KRRISETDLRPGELSGEEVEESEEEEEEEEEEDQEEQEESKAGGEDQLWRPYYSYKPKRKAGATA 654

  Fly   707 -----VSVAPANK-----------------------------PKSHFCASCGKGFAAKHGLMQHN 737
                 ||..|..:                             .:.|.|..|.:.||....|.:|.
Mouse   655 GGASGVSGLPRGRRPPRWRQKLERRGWEETPSVEGPGGRGRGERRHRCGDCAQAFATVRKLRKHQ 719

  Fly   738 RRHPNGGCTVRT-------HVC-ECGKAFFQKNHLMLHQRQHLETKP--------AISQ------ 780
            ..|..|..|.||       ..| .|.|.......|..|.::|...:|        |.|:
Mouse   720 EAHSGGSHTSRTGRRSSTRFTCPHCAKVCKTAAALNRHGQRHAVERPGGTPTPVIAYSKGSIGTR 784

  Fly   781 ----QQEAATQQQL--------------ATAGEQQQVQVQIMPDGQ 808
                ::||..:.|:              |.|.|...:|..::..|:
Mouse   785 PTDVKEEAPQEMQVSSSSGEAGSGSAAAAEASESASLQDPVISGGE 830

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	26/109 (24%)
		C2H2 Zn finger	294..314	CDD:275368	10/28 (36%)
		zf-H2C2_2	306..331	CDD:290200	7/33 (21%)
		C2H2 Zn finger	322..342	CDD:275368	4/36 (11%)
		C2H2 Zn finger	350..370	CDD:275368	6/19 (32%)
		zf-H2C2_2	362..385	CDD:290200	9/22 (41%)
		C2H2 Zn finger	378..398	CDD:275368	5/19 (26%)
		zf-H2C2_2	390..415	CDD:290200	9/24 (38%)
		C2H2 Zn finger	406..426	CDD:275368	6/20 (30%)
		SIR2	<425..>465	CDD:294129	10/43 (23%)
		C2H2 Zn finger	434..454	CDD:275368	5/23 (22%)
		C2H2 Zn finger	461..482	CDD:275368	1/20 (5%)
		C2H2 Zn finger	490..509	CDD:275368	2/18 (11%)
		lambda-1	491..>603	CDD:212564	14/128 (11%)
		C2H2 Zn finger	575..595	CDD:275368	1/36 (3%)
		C2H2 Zn finger	720..740	CDD:275368	6/19 (32%)
		C2H2 Zn finger	752..771	CDD:275368	5/19 (26%)
Zbtb4	NP_001350107.1	BTB_POZ_ZBTB4	12..160	CDD:349504	36/206 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..103		11/63 (17%)
		Interaction with CBFA2T3. /evidence=ECO:0000250\|UniProtKB:Q9P1Z0	165..324		40/184 (22%)
		zf-C2HC_2	211..233	CDD:372809	9/21 (43%)
		C2H2 Zn finger	212..228	CDD:275370	7/15 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	234..255		4/20 (20%)
		C2H2 Zn finger	287..307	CDD:275368	6/19 (32%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		C2H2 Zn finger	343..361	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	404..578		33/200 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	591..700		7/108 (6%)
		C2H2 Zn finger	704..722	CDD:275368	5/17 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	715..738		7/22 (32%)
		zf-C2H2	739..761	CDD:333835	5/21 (24%)
		C2H2 Zn finger	741..761	CDD:275368	5/19 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	759..839		12/72 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	854..880
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100