DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and Zfp169

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_011242711.1	Gene:	Zfp169 / 67911	MGIID:	1915161	Length:	732	Species:	Mus musculus

Alignment Length:	552	Identity:	170/552 - (30%)
Similarity:	226/552 - (40%)	Gaps:	153/552 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 ERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTH--------------- 338
            |:||||.|||..|..|..||.|.|.|:||:||:|..||:.|.:...||:|
Mouse   255 EKPYSCSECGHQFAQKASLTVHQRKHSGEKPHVCEECGRGFMYVSSLNSHKKIIHSGESPLVCPE 319

  Fly   339 ----------LLLHS----TERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKR 389
                      ||||.    .::|:.|.||.:.|..|..||.||..||.:.||:|..|||.|.|..
Mouse   320 CGRGFRQKIDLLLHQRTHLDKKPFVCPECGRGFCRKASLLQHSWSHSGDNPFICSVCGRGFRLLS 384

  Fly   390 HLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH 454
            .|:||...|:||:|:||.:||:.|.|:..|:.|.:.|....||||.:||.||.:|..|:.|.|||
Mouse   385 RLLTHQVTHSGEKPHVCPDCGQRFGQKGTLMRHQKTHTGEKPFVCRQCGWSFTQKVNLIRHQRIH 449

  Fly   455 GKI-PHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNG----V 514
            .:: |..|..||:.|..|..|..| |:.|.||:.:.|..||.||..|..|..|.| .|.|    :
Mouse   450 TEVKPFLCPECGRAFEFKSLLTRH-RKTHMGEKPYVCPQCGRGFSQKFNLIGHQR-IHTGELPFL 512

  Fly   515 NPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECG 579
            .|....|.:   :|.....|    |:||.                       |..:| :.|.|||
Mouse   513 CPECGRAFV---KQSMLIRH----QRTHA-----------------------GWEKP-YQCPECG 546

  Fly   580 SAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQI 644
            ..|..:..|..|.::|||:|..:...|                  |...:...||:|.
Mouse   547 RTFEFKSLLTRHQKIHTGEKPYVCPQC------------------GRGFSQKFNLIGH------- 586

  Fly   645 ISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSV 709
                             ..||......|.|            ...|:.:|:....:.|:.|.
Mouse   587 -----------------QKTHTGEKPYACP------------QCGQRFRQKFNLARHQRIHT--- 619

  Fly   710 APANKPKSHFCASCGKGFAAKHGLMQHNRRHPNG---GCT---------------VRTH------ 750
              ..||  ..||.||:.|..|..|::|.|.|...   .||               .:||
Mouse   620 --GEKP--FLCAECGRAFGKKVSLIRHQRTHGEEKPYQCTECGRAFEFKSLFIRHQKTHTGEKPY 680

  Fly   751 VC-ECGKAFFQKNHLMLHQRQHLETKPAISQQ 781
            || ||||||.||.:|:.|||.|...||.:..|
Mouse   681 VCPECGKAFSQKFNLIGHQRSHTGEKPYLCPQ 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	40/110 (36%)
		C2H2 Zn finger	294..314	CDD:275368	10/19 (53%)
		zf-H2C2_2	306..331	CDD:290200	13/24 (54%)
		C2H2 Zn finger	322..342	CDD:275368	9/44 (20%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		zf-H2C2_2	362..385	CDD:290200	12/22 (55%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		zf-H2C2_2	390..415	CDD:290200	12/24 (50%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		SIR2	<425..>465	CDD:294129	17/40 (43%)
		C2H2 Zn finger	434..454	CDD:275368	9/19 (47%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	8/18 (44%)
		lambda-1	491..>603	CDD:212564	30/115 (26%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368	9/19 (47%)
		C2H2 Zn finger	752..771	CDD:275368	13/19 (68%)
Zfp169	XP_011242711.1	KRAB	14..73	CDD:214630
		C2H2 Zn finger	233..252	CDD:275368
		COG5048	256..727	CDD:227381	169/551 (31%)
		C2H2 Zn finger	260..280	CDD:275368	10/19 (53%)
		C2H2 Zn finger	288..309	CDD:275368	7/20 (35%)
		C2H2 Zn finger	317..337	CDD:275368	4/19 (21%)
		C2H2 Zn finger	345..365	CDD:275368	9/19 (47%)
		C2H2 Zn finger	373..393	CDD:275368	9/19 (47%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		C2H2 Zn finger	429..449	CDD:275368	9/19 (47%)
		C2H2 Zn finger	457..477	CDD:275368	8/20 (40%)
		C2H2 Zn finger	485..505	CDD:275368	9/20 (45%)
		C2H2 Zn finger	513..533	CDD:275368	5/26 (19%)
		C2H2 Zn finger	542..562	CDD:275368	7/19 (37%)
		C2H2 Zn finger	570..590	CDD:275368	5/61 (8%)
		C2H2 Zn finger	598..618	CDD:275368	4/31 (13%)
		C2H2 Zn finger	626..646	CDD:275368	9/19 (47%)
		C2H2 Zn finger	654..674	CDD:275368	2/19 (11%)
		C2H2 Zn finger	682..702	CDD:275368	13/19 (68%)
		C2H2 Zn finger	710..730	CDD:275368	1/3 (33%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	2	1.870