DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and PRDM15

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_011527985.1	Gene:	PRDM15 / 63977	HGNCID:	13999	Length:	1441	Species:	Homo sapiens

Alignment Length:	662	Identity:	166/662 - (25%)
Similarity:	243/662 - (36%)	Gaps:	129/662 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   130 AGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFSSIGALHLTQEECNEILIKRAIAAGH 194
            |||:: |..:....:|..|..|    |.:..|...| |..:.|....|.|.|.....:..:...|
Human   823 AGGEN-LVRYKKEPSGCPVCGK----VFSCRSNMNK-HLLTHGDKKYTCEICGRKFFRVDVLRDH 881

  Fly   195 HQTHTITAADGSHHHASGGTPSFCSVGGATTLLGDILPGISVQVQKVIQGLEDNEDSQGEAPNLK 259
            ...|....|....|...             ..:|.|  |||.:..      :||.|...::...|
Human   882 IHVHFKDIALMDDHQRE-------------EFIGKI--GISSEEN------DDNSDESADSEPHK 925

  Fly   260 LEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERP----- 319
            ......:|:.....:...|..|    :.||:.|.|..|.:.|.||.....|..:|....|
Human   926 YSCKRCQLTFGRGKEYLKHIME----VHKEKGYGCSICNRRFALKATYHAHMVIHRENLPDPNVQ 986

  Fly   320 ---HICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQEC 381
               |.|..||:.|.....|..|.|:|:..:.:.|::|.|||..|..|..|.|||...|.::|.||
Human   987 KYIHPCEICGRIFNSIGNLERHKLIHTGVKSHACEQCGKSFARKDMLKEHMRVHDNVREYLCAEC 1051

  Fly   382 GRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQ 446
            |:....|..|..|.|.|.|.:.|.|:||...|||:.:::.|.:.|..:..|:|..||.:|..:..
Human  1052 GKGMKTKHALRHHMKLHKGIKEYECKECHRRFAQKVNMLKHCKRHTGIKDFMCELCGKTFSERNT 1116

  Fly   447 LVNHGRIH--GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRT 509
            :..|..||  || ..:|:||.|:::.:..|..|::..|...:|..|..||....|:|.:.:|:|.
Human  1117 METHKLIHTVGK-QWTCSVCDKKYVTEYMLQKHVQLTHDKVEAQSCQLCGTKVSTRASMSRHMRR 1180

  Fly   510 AHNGV----------NPNT-----SSATII------ANQQLQQAHHHQAGQQTH----------- 542
            .|..|          .|.|     ||..|:      ..:.|.:..|.:|.:::|
Human  1181 KHPEVLAVRIDDLDHLPETTTIDASSIGIVQPELTLEQEDLAEGKHGKAAKRSHKRKQKPEEEAG 1245

  Fly   543 ---PQTITV------------------------------------VSNPGNSTLLT-VSTTDANG 567
               |:..|.                                    |:.|.:|..|| ::.|....
Human  1246 APVPEDATFSEYSEKETEFTGSVGDETNSAVQSIQQVVVTLGDPNVTTPSSSVGLTNITVTPITT 1310

  Fly   568 VARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANP 632
            .|..||.        |.:.....||.  |.::.|..|...||........|....|....|..:|
Human  1311 AAATQFT--------NLQPVAVGHLT--TPERQLQLDNSILTVTFDTVSGSAMLHNRQNDVQIHP 1365

  Fly   633 NLVGQSPVPV-QIISSTGQVMSQTTLVQAANSTHPQAVVTAVP---TMPVHGQQQHLQHVAQQQQ 693
            .....:|..| ..|:.|..|.|.|.|....:..|| ....|||   .:|....|...|..||.|.
Human  1366 QPEASNPQSVAHFINLTTLVNSITPLGSQLSDQHP-LTWRAVPQTDVLPPSQPQAPPQQAAQPQV 1429

  Fly   694 QQQQQQQQQQQH 705
            |.:|||||...:
Human  1430 QAEQQQQQMYSY 1441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	30/91 (33%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		zf-H2C2_2	306..331	CDD:290200	8/32 (25%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		zf-H2C2_2	362..385	CDD:290200	10/22 (45%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		SIR2	<425..>465	CDD:294129	13/41 (32%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	461..482	CDD:275368	6/20 (30%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	33/183 (18%)
		C2H2 Zn finger	575..595	CDD:275368	3/19 (16%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
PRDM15	XP_011527985.1	SET	349..465	CDD:214614
		GAGA_bind	<515..>580	CDD:283799
		COG5048	663..1125	CDD:227381	89/332 (27%)
		zf-C2H2	672..694	CDD:278523
		C2H2 Zn finger	674..694	CDD:275368
		C2H2 Zn finger	701..722	CDD:275368
		C2H2 Zn finger	735..751	CDD:275368
		C2H2 Zn finger	789..809	CDD:275368
		C2H2 Zn finger	838..858	CDD:275368	6/24 (25%)
		C2H2 Zn finger	865..885	CDD:275368	3/19 (16%)
		C2H2 Zn finger	928..949	CDD:275370	3/24 (13%)
		C2H2 Zn finger	956..976	CDD:275368	6/19 (32%)
		C2H2 Zn finger	992..1012	CDD:275368	7/19 (37%)
		zf-H2C2_2	1004..1029	CDD:290200	9/24 (38%)
		C2H2 Zn finger	1020..1040	CDD:275368	9/19 (47%)
		C2H2 Zn finger	1048..1068	CDD:275368	8/19 (42%)
		zf-H2C2_2	1060..1085	CDD:290200	10/24 (42%)
		C2H2 Zn finger	1076..1096	CDD:275368	7/19 (37%)
		C2H2 Zn finger	1104..1124	CDD:275368	5/19 (26%)
		C2H2 Zn finger	1132..1153	CDD:275368	6/20 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	0	0.000