DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and Repin1

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001073372.2	Gene:	Repin1 / 58887	MGIID:	1889817	Length:	601	Species:	Mus musculus

Alignment Length:	348	Identity:	120/348 - (34%)
Similarity:	154/348 - (44%)	Gaps:	99/348 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   289 ERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHS---------- 343
            |||:.|.||||.|..|.:||:|.|:||||:|:.||.||:.|.||..|.:|..:|.
Mouse   310 ERPHQCPECGKRFTNKPYLTSHRRIHTGEKPYPCTECGRRFRHKPNLLSHSKIHKRLEVSAQAAP 374

  Fly   344 ---------------------------TERP---YQCQECKKSFTLKHHLLTHSRVHSRERPFVC 378
                                       .|.|   :.|.:|.:||.|:..|..|.|.|:.||||.|
Mouse   375 HPESHQIAAEPMAQPALGVPLGSPRTPAEAPALLHSCSDCGRSFRLERFLRLHQRQHTGERPFAC 439

  Fly   379 QECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPR 443
            .|||:.|..|.|||.||:.|:||||:.|||||..|:|.:||..|.|.|....||||.:||.:|..
Mouse   440 TECGKNFGKKTHLVAHSRVHSGERPFACEECGRRFSQGSHLAAHRRDHAPERPFVCPDCGKAFRH 504

  Fly   444 KFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHV 507
            |..|..|.||| |:.|:.|..|||.|.||..|||| ||:||||:.:.|..|...|..|:.|..|
Mouse   505 KPYLAAHRRIHTGEKPYVCPDCGKAFSQKSNLVSH-RRIHTGERPYACPDCDRSFSQKSNLITH- 567

  Fly   508 RTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQ 572
            |.:|                                                        :....
Mouse   568 RKSH--------------------------------------------------------IRDGA 576

  Fly   573 FVCRECGSAFNSREALALHLRLH 595
            |.|..||..|:..:.|.:|.:.|
Mouse   577 FCCAICGQTFDDEDRLLMHQKKH 599

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	39/121 (32%)
		C2H2 Zn finger	294..314	CDD:275368	11/19 (58%)
		zf-H2C2_2	306..331	CDD:290200	14/24 (58%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		zf-H2C2_2	362..385	CDD:290200	12/22 (55%)
		C2H2 Zn finger	378..398	CDD:275368	11/19 (58%)
		zf-H2C2_2	390..415	CDD:290200	16/24 (67%)
		C2H2 Zn finger	406..426	CDD:275368	11/19 (58%)
		SIR2	<425..>465	CDD:294129	17/40 (43%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..482	CDD:275368	13/20 (65%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	15/105 (14%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
Repin1	NP_001073372.2	C2H2 Zn finger	110..130	CDD:275368
		C2H2 Zn finger	138..158	CDD:275368
		C2H2 Zn finger	169..189	CDD:275368
		C2H2 Zn finger	198..216	CDD:275368
		C2H2 Zn finger	230..250	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368
		zf-H2C2_2	299..324	CDD:290200	9/13 (69%)
		COG5048	<303..574	CDD:227381	112/321 (35%)
		C2H2 Zn finger	315..335	CDD:275368	11/19 (58%)
		zf-H2C2_2	327..352	CDD:290200	14/24 (58%)
		C2H2 Zn finger	343..363	CDD:275368	9/19 (47%)
		C2H2 Zn finger	411..431	CDD:275368	8/19 (42%)
		zf-H2C2_2	424..446	CDD:290200	12/21 (57%)
		C2H2 Zn finger	439..459	CDD:275368	11/19 (58%)
		zf-H2C2_2	451..476	CDD:290200	16/24 (67%)
		C2H2 Zn finger	467..487	CDD:275368	11/19 (58%)
		C2H2 Zn finger	495..515	CDD:275368	8/19 (42%)
		zf-H2C2_2	507..532	CDD:290200	12/24 (50%)
		C2H2 Zn finger	523..543	CDD:275368	13/20 (65%)
		zf-H2C2_2	535..560	CDD:290200	13/25 (52%)
		C2H2 Zn finger	551..571	CDD:275368	7/20 (35%)
		C2H2 Zn finger	579..599	CDD:275368	6/19 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960