Protein Alignment cg and RBAK

DIOPT Version :10

• Sequence 1: NP_001097306.2
• Gene: cg / 36571
• FlyBaseID: FBgn0000289
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_066986.1
• Gene: RBAK / 57786
• HGNCID: 17680
• Length: 714
• Species: Homo sapiens
• Alignment Length: 684
• Identity: 183/684 - (26%)
• Similarity: 262/684 - (38%)
• Gaps: 188/684 - (27%)

  Fly   171 IGALHLTQEECN--------------EILIKRAIAAGHH--QTHTITAADGSHHHASGGTPSFCS 219
            |.:..||:|:.|              .|:....::.|.:  ....:.::|||:....   |..|:
Human   105 INSKTLTEEKENTFSQIYMETSLVPSSIIAHNCVSCGKNLESISQLISSDGSYARTK---PDECN 166

  Fly   220 VGGAT---------TLLGD--------ILPGISV-----QVQKVIQGLEDNE--------DSQGE 254
            ..|.|         ...||        ||..||:     :..:.::.| |||        ...||
Human   167 ECGKTYHGEKMCEFNQNGDTYSHNEENILQKISILEKPFEYNECMEAL-DNEAVFIAHKRAYIGE 230

  Fly   255 APNLKLEPGTLELSPKTELQESMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERP 319
            .|....:.|       .:..:..:|:....:..:.:|:.|.||||||..|.....|.|.||||:|
Human   231 KPYEWNDSG-------PDFIQMSNFNAYQRSQMEMKPFECSECGKSFCKKSKFIIHQRAHTGEKP 288

  Fly   320 HICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRA 384
            :.|..|||||:.|..|..|...|..|:||:|.||.|:|..|.||..|.|.||.|:|:.|.|||:.
Human   289 YECNVCGKSFSQKGTLTVHRRSHLEEKPYKCNECGKTFCQKLHLTQHLRTHSGEKPYECSECGKT 353

  Fly   385 FPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVN 449
            |..|.||..|.:.|:|||||.|.|||:||::::.|..|.|.|.....:.|.|||.|:.||..|:.
Human   354 FCQKTHLTLHQRNHSGERPYPCNECGKSFSRKSALSDHQRTHTGEKLYKCNECGKSYYRKSTLIT 418

  Fly   450 HGRIH-GKIPHSCTVCGKEFLQKRTLVSHM---------------------------RRVHTGEQ 486
            |.|.| |:.|:.|:.|||.|.:...|..|.                           |:|||.|:
Human   419 HQRTHTGEKPYQCSECGKFFSRVSYLTIHYRSHLEEKPYECNECGKTFNLNSAFIRHRKVHTEEK 483

  Fly   487 AHPCVSCGEGFLTKAELHQHVRTAHNGVNP---NTSSATIIANQQLQQAHHHQAGQQTHPQTITV 548
            :|.|..||:  .::..|..| .|||....|   |....|.:.|...........|::::  ...|
Human   484 SHECSECGK--FSQLYLTDH-HTAHLEEKPYECNECGKTFLVNSAFDGHQPLPKGEKSY--ECNV 543

  Fly   549 VSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALP 613
            .....|..........::...:| :.|.|||..|:...:|..|.|:|||:|......|
Human   544 CGKLFNELSYYTEHYRSHSEEKP-YGCSECGKTFSHNSSLFRHQRVHTGEKPYECYEC------- 600

  Fly   614 GHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPV 678
            |.|.|..|.                                                     :.:
Human   601 GKFFSQKSY-----------------------------------------------------LTI 612

  Fly   679 HGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRHPNG 743
            |    |..|..:                         |.:.|:.|||.|:....|..|.|.|..
Human   613 H----HRIHSGE-------------------------KPYECSKCGKVFSRMSNLTVHYRSHSG- 647

  Fly   744 GCTVRTHVC-ECGKAFFQKNHLMLHQRQHLETKP 776
               .:.:.| ||||.|.||::|.:|.|.|...||
Human   648 ---EKPYECNECGKVFSQKSYLTVHYRTHSGEKP 678

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	39/83 (47%)
		C2H2 Zn finger	294..314	CDD:275368	10/19 (53%)
		zf-H2C2_2	306..331	CDD:463886	13/24 (54%)
		C2H2 Zn finger	322..342	CDD:275368	9/19 (47%)
		C2H2 Zn finger	350..370	CDD:275368	10/19 (53%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		C2H2 Zn finger	434..454	CDD:275368	10/19 (53%)
		C2H2 Zn finger	461..482	CDD:275368	8/47 (17%)
		C2H2 Zn finger	490..509	CDD:275368	5/18 (28%)
		C2H2 Zn finger	575..595	CDD:275368	8/19 (42%)
		C2H2 Zn finger	720..740	CDD:275368	8/19 (42%)
		C2H2 Zn finger	752..771	CDD:275368	11/19 (58%)
RBAK	NP_066986.1	KRAB	8..68	CDD:214630
		C2H2 Zn finger	165..199	CDD:275368	7/33 (21%)
		Required for interaction with RB1. /evidence=ECO:0000269|PubMed:10702291	171..260		16/96 (17%)
		C2H2 Zn finger	207..227	CDD:275368	4/20 (20%)
		SUF4-like	259..>307	CDD:411020	24/47 (51%)
		C2H2 Zn finger	263..284	CDD:411020	10/20 (50%)
		C2H2 Zn finger	263..283	CDD:275368	10/19 (53%)
		C2H2 Zn finger	291..311	CDD:275368	9/19 (47%)
		zf-C2H2	317..339	CDD:395048	11/21 (52%)
		C2H2 Zn finger	319..339	CDD:275368	10/19 (53%)
		COG5048	343..701	CDD:227381	112/435 (26%)
		C2H2 Zn finger	347..367	CDD:275368	9/19 (47%)
		C2H2 Zn finger	375..395	CDD:275368	9/19 (47%)
		C2H2 Zn finger	403..423	CDD:275368	10/19 (53%)
		Interaction with AR. /evidence=ECO:0000269|PubMed:14664718	417..714		78/361 (22%)
		C2H2 Zn finger	431..451	CDD:275368	7/19 (37%)
		C2H2 Zn finger	459..479	CDD:275368	1/19 (5%)
		C2H2 Zn finger	513..533	CDD:275368	3/19 (16%)
		C2H2 Zn finger	541..561	CDD:275368	2/19 (11%)
		C2H2 Zn finger	569..589	CDD:275368	8/19 (42%)
		C2H2 Zn finger	597..617	CDD:275368	7/83 (8%)
		C2H2 Zn finger	625..645	CDD:275368	8/19 (42%)
		C2H2 Zn finger	653..673	CDD:275368	11/19 (58%)
		C2H2 Zn finger	681..701	CDD:275368