DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and si:ch211-79k12.2

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001313520.1	Gene:	si:ch211-79k12.2 / 568844	ZFINID:	ZDB-GENE-131121-535	Length:	555	Species:	Danio rerio

Alignment Length:	595	Identity:	154/595 - (25%)
Similarity:	217/595 - (36%)	Gaps:	156/595 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 LDKNYLLVDPATAAAAAAAAGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFSSIGALH 175
            :||:.|            |||..|.|..||.:.:            |.|.||....|       .
Zfish     1 MDKDRL------------AAGPCSWLDMHHFIGD------------LMAASATVTGH-------P 34

  Fly   176 LTQEECNEIL-------------------IKRAIAAG---------HHQTH----TITAADGSHH 208
            :.:....|.|                   :|.|:..|         |:::|    |.| ..|...
Zfish    35 MAERRTEETLSSWPKVPHPPQSIPSRQNPVKNAVRFGVQSEEREPRHNESHAHRRTCT-CPGCPL 98

  Fly   209 HASGGTPSFCSVGGATTLLGDILPGISVQVQKVIQ-----------------GLEDNEDSQGEA- 255
            .::..:.||.::....:....|.|..|.|...:.|                 ||..:|::.|.:
Zfish    99 SSTPSSSSFQTLKPKASSASQIQPPSSTQSTPLQQAKEPSTAPVSLGLCLGLGLSLDEENTGSSS 163

  Fly   256 ---PNLKLEPGTLELSPKTELQ-ESMHFSETDATIKKERPYSCDECGKSF--------------- 301
               |..:.:.||...||..:.. ||...|...|       :.|..|.:.|
Zfish   164 TSRPPQQEDKGTSTHSPIPQSNPESPGVSPAQA-------FPCVCCHRGFQTCSQLLSQQKDPES 221

  Fly   302 LLKHHLTTHARVHTGERP-HICTHC-GKSFAHKHCLNT-----HLLLHSTERPYQ-------CQE 352
            .:.||...|...|.   | ..||.| ..||....|..|     .||.|......|       |..
Zfish   222 QIAHHYYHHHHHHC---PLSSCTSCTHPSFPCLSCQRTFPTCAQLLRHEQGHAQQDGLQQLSCMH 283

  Fly   353 CKKSFTLKHHLLTHSRVH--SRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQ 415
            |..||.....||.|.|..  ::...|:|.||||||....:|..|...|.|.|||:|..||:||:|
Zfish   284 CNASFPRPSQLLQHQRTQHATKAGGFLCAECGRAFNSHSNLRIHLNVHTGARPYICTNCGKSFSQ 348

  Fly   416 ENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMR 479
            ...|.:|.|.|....|:.|:.||..||....:..|.||| |:.|:.|..|||.|.|...|..| .
Zfish   349 SGALKIHRRIHTGERPYTCSYCGRGFPHLAGVRAHQRIHTGEKPYICGQCGKCFTQSGALKIH-T 412

  Fly   480 RVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGV-NPN---------TSSATIIANQQLQ---- 530
            |:||||:...|..||:.|..::.:..|.||.|..| .||         ::|:.:...|::|
Zfish   413 RIHTGERPFVCGLCGKSFSNRSGIRFHHRTVHGIVMEPNSVGRPSLAASASSQVSDIQRVQVSAV 477

  Fly   531 -QAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAF-----NSREALA 589
             |.|..|..::..|....|  .|....|    :.:|:.:|.| :.|.:||..|     .:|....
Zfish   478 NQIHFRQIEERNLPSKELV--QPSKEQL----SGNADKLALP-YACEDCGQRFPDAPSRNRHQTL 535

  Fly   590 LHLRLHTGDK 599
            .|..|...:|
Zfish   536 QHYSLEEQEK 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	27/114 (24%)
		C2H2 Zn finger	294..314	CDD:275368	6/34 (18%)
		zf-H2C2_2	306..331	CDD:290200	9/26 (35%)
		C2H2 Zn finger	322..342	CDD:275368	9/25 (36%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		zf-H2C2_2	362..385	CDD:290200	10/24 (42%)
		C2H2 Zn finger	378..398	CDD:275368	9/19 (47%)
		zf-H2C2_2	390..415	CDD:290200	12/24 (50%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		SIR2	<425..>465	CDD:294129	14/40 (35%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..482	CDD:275368	9/20 (45%)
		C2H2 Zn finger	490..509	CDD:275368	5/18 (28%)
		lambda-1	491..>603	CDD:212564	31/129 (24%)
		C2H2 Zn finger	575..595	CDD:275368	6/24 (25%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
si:ch211-79k12.2	NP_001313520.1	C2H2 Zn finger	281..302	CDD:275368	8/20 (40%)
		C2H2 Zn finger	311..331	CDD:275368	9/19 (47%)
		zf-H2C2_2	323..348	CDD:290200	12/24 (50%)
		C2H2 Zn finger	339..359	CDD:275368	9/19 (47%)
		zf-H2C2_2	351..374	CDD:290200	8/22 (36%)
		C2H2 Zn finger	367..387	CDD:275368	7/19 (37%)
		zf-H2C2_2	380..404	CDD:290200	11/23 (48%)
		C2H2 Zn finger	395..415	CDD:275368	9/20 (45%)
		zf-H2C2_2	407..432	CDD:290200	11/25 (44%)
		C2H2 Zn finger	423..442	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100