Protein Alignment cg and Plag1

DIOPT Version :10

• Sequence 1: NP_001097306.2
• Gene: cg / 36571
• FlyBaseID: FBgn0000289
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_064353.2
• Gene: Plag1 / 56711
• MGIID: 1891916
• Length: 499
• Species: Mus musculus
• Alignment Length: 417
• Identity: 105/417 - (25%)
• Similarity: 162/417 - (38%)
• Gaps: 111/417 - (26%)

  Fly   227 LGDILPGISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTELQESMHFSETDATIKKERP 291
            :..::||          .|.:..|:| :||:.|.:.|           ||          |..:.
Mouse     1 MATVIPG----------DLSEVRDTQ-KAPSGKRKRG-----------ES----------KPRKN 33

  Fly   292 YSCDECGKSFLLKHHLTTHARVHTGERPHICTH--CGKSFAHKHCLNTHLLLHSTERPYQCQECK 354
            :.|..|.|:|.....|..|:..||||||:.|||  |.|:|..|:.|..|:..||.|:.::|..|:
Mouse    34 FPCQLCDKAFNSVEKLKVHSFSHTGERPYKCTHQDCTKAFVSKYKLQRHMATHSPEKTHKCNYCE 98

  Fly   355 KSFTLKHHLLTHSRVHS-RERPFVCQECGRAF----PLKRHLVTHSKFHAGERPYVCEECGESFA 414
            |.|..|.||..|...|. .:..|.|:|||:::    ..||||..|:   |......|:.|.::|.
Mouse    99 KMFHRKDHLKNHLHTHDPNKETFKCEECGKSYNTKLGFKRHLALHA---ATSGDLTCKVCLQNFE 160

  Fly   415 QENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKI---PHSCTVCGKEFLQKRTLVS 476
            ....|:.|.:.|.                       |:..|.:   .|.|..|.:.|..::.:..
Mouse   161 STGVLLEHLKSHA-----------------------GKSSGGVKEKKHQCEHCERRFYTRKDVRR 202

  Fly   477 HMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNG------------VNPNTSSATIIANQQL 529
            || .||||.:...|..|.:.|..|..|.:|::.:||.            ::|.|.:.::....:|
Mouse   203 HM-VVHTGRKDFLCQYCAQRFGRKDHLTRHMKKSHNQELLKVKTEPVDFLDPFTCNMSVPIKDEL 266

  Fly   530 QQAHHHQAGQQTHPQTITVVSNPGNSTLLT---VSTTDANGVARPQFVCRECGSAFNSREALALH 591
                            :.|:|.| :|.||:   .:|...|....|....:..|||......|.|.
Mouse   267 ----------------LPVMSLP-SSELLSKPFTNTLQLNLYNTPFQSMQSSGSAHQMITTLPLG 314

  Fly   592 LRLHTGDKSLMTDLCALTAALPGHFLS 618
                      ||....:.|..|.|.|:
Mouse   315 ----------MTCPIDMDAVHPSHHLA 331

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	33/85 (39%)
		C2H2 Zn finger	294..314	CDD:275368	6/19 (32%)
		zf-H2C2_2	306..331	CDD:463886	14/26 (54%)
		C2H2 Zn finger	322..342	CDD:275368	9/21 (43%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	9/23 (39%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		C2H2 Zn finger	434..454	CDD:275368	1/19 (5%)
		C2H2 Zn finger	461..482	CDD:275368	5/20 (25%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		C2H2 Zn finger	575..595	CDD:275368	5/19 (26%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
Plag1	NP_064353.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..33		12/63 (19%)
		Interaction with KPNA2. /evidence=ECO:0000250	2..84		33/113 (29%)
		Nuclear localization signal. /evidence=ECO:0000250	22..25		1/2 (50%)
		C2H2 Zn finger	36..56	CDD:275368	6/19 (32%)
		Decreased nuclear import with localization in the nucleus but also in the cytoplasm. /evidence=ECO:0000250	41..242		68/227 (30%)
		SFP1	<58..139	CDD:227516	31/80 (39%)
		C2H2 Zn finger	64..86	CDD:275368	9/21 (43%)
		zf-H2C2_2	79..101	CDD:463886	8/21 (38%)
		C2H2 Zn finger	94..114	CDD:275368	8/19 (42%)
		C2H2 Zn finger	123..143	CDD:275368	8/19 (42%)
		C2H2 Zn finger	152..172	CDD:275368	5/19 (26%)
		C2H2 Zn finger	187..207	CDD:275368	5/20 (25%)
		C2H2 Zn finger	215..233	CDD:275368	6/17 (35%)
		Activates transcription, Inhibition of nuclear import due to lack of NLS and KPNA2 interaction. /evidence=ECO:0000250	243..499		23/116 (20%)
		Repression domain, contains 3 sumoylation motifs and massively decrease transcription activity. /evidence=ECO:0000250	243..383		23/116 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	365..400
		Massively activates transcription. /evidence=ECO:0000250	384..499