DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and LOC563292

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_021332054.1	Gene:	LOC563292 / 563292	-ID:	-	Length:	749	Species:	Danio rerio

Alignment Length:	767	Identity:	155/767 - (20%)
Similarity:	232/767 - (30%)	Gaps:	246/767 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    86 TQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHHTLTNGSIVDA 150
            |:.|:..|      ::|:::.....   :||::....|....:..|.:       ....|:|.|.
Zfish   109 TEDVLVEG------REQEHDSDSCG---DYLMISLDDAGKMVSGDGDE-------VTVEGAIDDQ 157

  Fly   151 KT-----GQTVLTAGSAAAKSHFSSIG-ALHLTQEECNEILIKRAIAAGHHQTHTITAADGSHHH 209
            :.     ||.|:......|.|....:| .:.|.:.|  .:.:...:.....:...::..||.|..
Zfish   158 EVEKDEDGQEVIKVYIFKADSGEDDLGETVDLGENE--TVALAEPVVRPLREKIYMSVGDGHHTQ 220

  Fly   210 ASGGTP------SFCSVGG-----------ATTLLGDILPGISVQVQKVIQGLEDN-EDSQGEAP 256
            ..||:.      ....|||           :|.|..|.:|   |.......|.::. |:..|.|.
Zfish   221 TDGGSKLSDEVYMEVVVGGEEPVPHDRPYDSTALSKDFMP---VAWAAAYAGADEGCENRNGAAS 282

  Fly   257 NLKLEPGTLELSPKTELQESMHFSETDATIKKERP----------------------------YS 293
            .|                  :|..|:||..|..|.                            |.
Zfish   283 AL------------------LHIDESDALDKLNRQHGKNRRRAEPRQVQTAIIIGPYGQPLTVYP 329

  Fly   294 CDECGKSF----LLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLH--STERPYQCQE 352
            |..|||.|    .||.|...|.:.....:.:.||.|..:...|..|:.|:.:|  |.:.|::|:.
Zfish   330 CMLCGKKFKSRGFLKRHTRNHHQDVLTRKKYQCTDCDFTTNKKASLHNHMEVHALSNKAPFECET 394

  Fly   353 CKKSF-----TLKHHLLTHSR------------------------------------------VH 370
            |.|.|     ...|.|..|.|                                          ||
Zfish   395 CGKEFHQQAALFSHRLQHHHREQKTPTAIASPLPPATANKTHKCKFCDYETAEQGLLNRHLLAVH 459

  Fly   371 SRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRF-HGSLNPFVC 434
            |:..|.:|.|||:.|.....|..|.:.|.||:||.|..|....|..::|..|.:. |....||.|
Zfish   460 SKSFPHICVECGKGFRHPSELKKHMRTHTGEKPYSCMYCDYKSADSSNLKTHVKTKHSRELPFRC 524

  Fly   435 AECGASFPRKFQLVNHGRIHGKI-PHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFL 498
            ..||.:|..:.:|..|...|... .|.|:.|.........|..|:..|||.:..|.|..|.:||.
Zfish   525 ERCGQTFAEEEELTQHATTHDDARGHQCSHCDHRSSNSSDLKRHIISVHTKDYPHKCAVCAKGFH 589

  Fly   499 TKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTT 563
            ..:||.:|
Zfish   590 RPSELKKH--------------------------------------------------------- 597

  Fly   564 DANGVARPQFVCRECGSAFNSREALALH-LRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTV 627
            .|:..|:....||.|....:....|:.| |.:||.:              |..........|.|.
Zfish   598 SASHKAKKMHQCRHCNFKISDPFVLSRHILSVHTKE--------------PQQTAQQQQQTPPTS 648

  Fly   628 VTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMP----VHGQQQHLQHV 688
            ....|. ..:||.|.:.|.                     |...|.|.:.    ..||::...:.
Zfish   649 PQQAPP-TEKSPAPKRTIG---------------------AAQLAAPAVKKAGGAKGQRERRVYQ 691

  Fly   689 AQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAAKHGLMQHNRRH 740
            .|............::||:|:...:.|  |.|..|.|||.......||..||
Zfish   692 CQYCDYSTGDASGFKRHVISIHTKDYP--HRCQYCSKGFRRPSEKNQHIMRH 741

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	30/164 (18%)
		C2H2 Zn finger	294..314	CDD:275368	9/23 (39%)
		zf-H2C2_2	306..331	CDD:290200	5/24 (21%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	8/66 (12%)
		zf-H2C2_2	362..385	CDD:290200	11/64 (17%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	9/24 (38%)
		C2H2 Zn finger	406..426	CDD:275368	5/20 (25%)
		SIR2	<425..>465	CDD:294129	12/41 (29%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..482	CDD:275368	4/20 (20%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	16/112 (14%)
		C2H2 Zn finger	575..595	CDD:275368	6/20 (30%)
		C2H2 Zn finger	720..740	CDD:275368	7/19 (37%)
		C2H2 Zn finger	752..771	CDD:275368
LOC563292	XP_021332054.1	Zfx_Zfy_act	43..313	CDD:309717	43/242 (18%)
		ROS_MUCR	<330..360	CDD:327679	9/29 (31%)
		C2H2 Zn finger	330..350	CDD:275368	8/19 (42%)
		C2H2 Zn finger	362..382	CDD:275368	6/19 (32%)
		C2H2 Zn finger	392..412	CDD:275368	6/19 (32%)
		C2H2 Zn finger	438..459	CDD:275368	0/20 (0%)
		COG5048	463..>518	CDD:227381	19/54 (35%)
		C2H2 Zn finger	467..487	CDD:275368	7/19 (37%)
		C2H2 Zn finger	495..516	CDD:275368	5/20 (25%)
		C2H2 Zn finger	524..544	CDD:275368	6/19 (32%)
		C2H2 Zn finger	552..573	CDD:275368	4/20 (20%)
		C2H2 Zn finger	581..601	CDD:275368	8/76 (11%)
		C2H2 Zn finger	609..626	CDD:275368	4/16 (25%)
		C2H2 Zn finger	692..713	CDD:275370	4/20 (20%)
		C2H2 Zn finger	721..741	CDD:275370	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100