DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and si:ch211-119o8.6

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001108212.1	Gene:	si:ch211-119o8.6 / 556659	ZFINID:	ZDB-GENE-070912-17	Length:	735	Species:	Danio rerio

Alignment Length:	584	Identity:	149/584 - (25%)
Similarity:	228/584 - (39%)	Gaps:	106/584 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   245 LEDNEDSQGEAP-------------NLKLEPG-TLELSPKTELQESMHFSETDATIKKERPYSCD 295
            |.:..|| ||.|             ||.|:.| :.|........|.:|        ..::|:.|.
Zfish   179 LTEPNDS-GEPPHLSTTTTCRSLRSNLCLKCGKSFERKSDLRAHEKVH--------SLQKPHQCS 234

  Fly   296 ECGKSFLLKHHLTTHARV----------------------------HTGERPHICTHCGKSFAHK 332
            .||||::.:|.|:.|.|:                            ||||:|..|:.|||||:.:
Zfish   235 TCGKSYVDRHELSMHERLHTGEKLFDCSYCKKKFVRESALKYHLRSHTGEKPFSCSQCGKSFSRR 299

  Fly   333 HCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKF 397
            ..|||||.||....|:||..|.|.|.....:..|...|:.||||.|.:|.:.|..|..|..|...
Zfish   300 STLNTHLRLHMGPLPHQCDHCGKLFNTAAAMRAHRATHTGERPFPCPQCDKKFIFKAELEVHLDG 364

  Fly   398 HAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSC 461
            |||.:|:.|..||:.|.::....:|...|.....|.|..|..||.|...|.:|.:|| .:.||.|
Zfish   365 HAGNKPFKCSVCGKGFLRKQECNVHQTIHQDKRSFHCTYCDNSFKRLSHLTSHLKIHYPESPHKC 429

  Fly   462 TVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATI-IA 525
            |.|.|.|....:|..| .|:||||:.:.|..||:.|.:..:     ||.|..|:....|... ..
Zfish   430 TYCEKSFKHPNSLKLH-ERLHTGEKPYSCEHCGKRFPSSGD-----RTRHLAVHSEVKSYKCPKC 488

  Fly   526 NQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQ---FVCRECGSAFNSREA 587
            :::.:..:..|:.|..|...........:.....::...|:.|...:   :.|.:||.||.....
Zfish   489 DRRFRFKNSLQSHQVMHTGERPFHCKKCDRDFARLANLKAHSVVHTEERSYSCSQCGQAFKCSST 553

  Fly   588 LALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVM 652
            |..|:.:|:....|....|..|............::.|              :.|...:..|:.:
Zfish   554 LKSHMIIHSSKTLLDCTTCGKTFTRHDTLKRHQDIHAG--------------IKVYKCTDCGKCL 604

  Fly   653 SQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQ----QQQQQQQQQQQHVVSVAPAN 713
            |..:.::    .|          |..|...:.:.:..:.::    ....|:.:|..|       :
Zfish   605 SSASCLK----LH----------MEGHSGNKKMYYCDECEKSFSSMSYLQKHRQMAH-------S 648

  Fly   714 KPKSHFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVC-ECGKAFFQKNHLMLHQRQHLETKP 776
            ..|...|..||:.|.:...|:.|..:|...    ..|.| ||||.|.:|..|..|.:.|.|.:|
Zfish   649 DEKPFVCFECGESFNSDGKLVTHQLQHSGR----MDHACTECGKKFARKETLRRHVKAHSEERP 708

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	35/111 (32%)
		C2H2 Zn finger	294..314	CDD:275368	9/47 (19%)
		zf-H2C2_2	306..331	CDD:290200	14/52 (27%)
		C2H2 Zn finger	322..342	CDD:275368	11/19 (58%)
		C2H2 Zn finger	350..370	CDD:275368	5/19 (26%)
		zf-H2C2_2	362..385	CDD:290200	8/22 (36%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		SIR2	<425..>465	CDD:294129	15/40 (38%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	4/18 (22%)
		lambda-1	491..>603	CDD:212564	22/115 (19%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368	6/19 (32%)
		C2H2 Zn finger	752..771	CDD:275368	9/19 (47%)
si:ch211-119o8.6	NP_001108212.1	COG5048	201..587	CDD:227381	112/399 (28%)
		C2H2 Zn finger	205..225	CDD:275370	4/19 (21%)
		C2H2 Zn finger	233..253	CDD:275368	9/19 (47%)
		C2H2 Zn finger	261..281	CDD:275368	0/19 (0%)
		zf-H2C2_2	273..298	CDD:290200	11/24 (46%)
		C2H2 Zn finger	289..309	CDD:275368	11/19 (58%)
		C2H2 Zn finger	317..337	CDD:275368	5/19 (26%)
		C2H2 Zn finger	345..362	CDD:275368	5/16 (31%)
		C2H2 Zn finger	373..393	CDD:275368	5/19 (26%)
		C2H2 Zn finger	401..421	CDD:275368	7/19 (37%)
		C2H2 Zn finger	429..449	CDD:275368	8/20 (40%)
		C2H2 Zn finger	457..477	CDD:275368	7/24 (29%)
		C2H2 Zn finger	485..505	CDD:275368	2/19 (11%)
		C2H2 Zn finger	513..533	CDD:275368	2/19 (11%)
		C2H2 Zn finger	541..561	CDD:275368	7/19 (37%)
		C2H2 Zn finger	569..589	CDD:275368	2/19 (11%)
		C2H2 Zn finger	597..614	CDD:275368	3/30 (10%)
		C2H2 Zn finger	626..647	CDD:275368	2/20 (10%)
		C2H2 Zn finger	655..675	CDD:275368	6/19 (32%)
		C2H2 Zn finger	683..703	CDD:275368	9/19 (47%)
		C2H2 Zn finger	711..731	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595233
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.930