DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and ZSCAN32

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001271456.1	Gene:	ZSCAN32 / 54925	HGNCID:	20812	Length:	697	Species:	Homo sapiens

Alignment Length:	259	Identity:	85/259 - (32%)
Similarity:	114/259 - (44%)	Gaps:	43/259 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   236 VQVQKVIQ--------------GLEDNEDSQGEAPNLKLEPGTLELSPKTELQESM--------- 277
            |::.|.:|              |||....|:.:..|   .||  |...||..||.|
Human   432 VEINKALQRKSRGVYWHSELQKGLESEPTSRRQCRN---SPG--ESEEKTPSQEKMSHQSFCARD 491

  Fly   278 ----HF-----------SETDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGK 327
                |.           |.....:|.|:...|.||||:|....:|..|.|:||||:||.|:.|||
Human   492 KACTHILCGKNCSQSVHSPHKPALKLEKVSQCPECGKTFSRSSYLVRHQRIHTGEKPHKCSECGK 556

  Fly   328 SFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLV 392
            .|:.:..|..||..|:.||||||.:|.|||.....|:.|.|.|:.|:|:.|..||:.|.......
Human   557 GFSERSNLTAHLRTHTGERPYQCGQCGKSFNQSSSLIVHQRTHTGEKPYQCIVCGKRFNNSSQFS 621

  Fly   393 THSKFHAGERPYVCEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGK 456
            .|.:.|.||.||.|..||:.|...:|...|.:.|....|:.|:.|...|.:...|..|..:|.|
Human   622 AHRRIHTGESPYKCAVCGKIFNNSSHFSAHRKTHTGEKPYRCSHCERGFTKNSALTRHQTVHMK 685

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	39/83 (47%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	14/24 (58%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	8/19 (42%)
		zf-H2C2_2	362..385	CDD:290200	9/22 (41%)
		C2H2 Zn finger	378..398	CDD:275368	5/19 (26%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		SIR2	<425..>465	CDD:294129	9/32 (28%)
		C2H2 Zn finger	434..454	CDD:275368	5/19 (26%)
		C2H2 Zn finger	461..482	CDD:275368
		C2H2 Zn finger	490..509	CDD:275368
		lambda-1	491..>603	CDD:212564
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
ZSCAN32	NP_001271456.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..33
		SCAN	33..142	CDD:128708
		SCAN	33..121	CDD:280241
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	144..177
		KRAB_A-box	218..250	CDD:295379
		Myb_DNA-bind_4	253..334	CDD:290549
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	347..395
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	451..482		12/35 (34%)
		COG5048	<455..668	CDD:227381	76/217 (35%)
		zf-C2H2	522..543	CDD:278523	9/20 (45%)
		C2H2 Zn finger	523..543	CDD:275368	9/19 (47%)
		zf-H2C2_2	535..559	CDD:290200	13/23 (57%)
		C2H2 Zn finger	551..571	CDD:275368	8/19 (42%)
		zf-H2C2_2	563..588	CDD:290200	14/24 (58%)
		C2H2 Zn finger	579..599	CDD:275368	8/19 (42%)
		zf-H2C2_2	591..616	CDD:290200	10/24 (42%)
		C2H2 Zn finger	607..627	CDD:275368	5/19 (26%)
		zf-H2C2_2	623..644	CDD:290200	10/20 (50%)
		C2H2 Zn finger	635..655	CDD:275368	6/19 (32%)
		zf-H2C2_2	647..671	CDD:290200	6/23 (26%)
		zf-C2H2	661..683	CDD:278523	5/21 (24%)
		C2H2 Zn finger	663..683	CDD:275368	5/19 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910