DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and CG4360

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_650879.1	Gene:	CG4360 / 42413	FlyBaseID:	FBgn0038787	Length:	556	Species:	Drosophila melanogaster

Alignment Length:	589	Identity:	136/589 - (23%)
Similarity:	182/589 - (30%)	Gaps:	243/589 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   121 ATAAAAAAA--------------AGGDSGLAHHHTLTNGSIVDAKTGQTVLTAGSAAAKSHFSSI 171
            ||||.||.|              .||..|.........||.....:||...|..::..:|.|
  Fly     6 ATAATAAMANYQHYQLPASHGGGGGGGGGGGGGGGSNGGSGPGPNSGQQQPTTLASLQQSPF--- 67

  Fly   172 GALH-LTQEECNEILIKRAIAAGHHQTH-----------------TITAADGSHHHASGGTPSFC 218
             ||| ||           |:.|..|.||                 |.||..|     .||
  Fly    68 -ALHQLT-----------AVQAIQHPTHQAMLHPQHPLVHLLDISTTTANSG-----GGG----- 110

  Fly   219 SVGGATTLLGDILPGISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTL--ELSPKTELQESMHFSE 281
              ||:.|   .|.| :..:||.||    ..|:...:.|..|.:....  :....|.|:..|.. .
  Fly   111 --GGSHT---PISP-MKQEVQSVI----SEEEVVVDDPRKKKQCHVCKNKFRQLTTLRNHMKI-H 164

  Fly   282 TDATIKKERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTE- 345
            ||     ||||.|..|.|:|.....||.|.::||||:|..|..|.|.|..:..|..|:..|...
  Fly   165 TD-----ERPYKCKHCDKAFRQISTLTNHVKIHTGEKPFTCNICAKDFRQQSTLINHIKTHKAAE 224

  Fly   346 -------------------------------------------------------RPYQCQECKK 355
                                                                   :|:||..||:
  Fly   225 SSTPTSLLNYQPQTGSGKHRKSQMHQAYQQQHQRVQISKTLYSGSYSSPAAEELVKPFQCSVCKR 289

  Fly   356 SFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQE---- 416
            .|.....|..|.|.|...:|:.|:.|.::|.....|..|.|.|.|::||.|..|...|.|:
  Fly   290 RFPQLSTLHNHERTHIDPKPYKCETCDKSFSQLATLANHKKIHTGDKPYTCSYCHMQFRQQSTLT 354

  Fly   417 NHLIMH--------------------------------------------SRFHGSL-------- 429
            |||..|                                            :..|||.
  Fly   355 NHLKTHTHQIAPGGVGGAGGGGGAVTATVDHSMPAPLAPGTQQLTSGLLPNNLHGSTANIIQLDH 419

  Fly   430 ------------------------------------------------------NPFVCAECGAS 440
                                                                  .||.|:.|...
  Fly   420 HPLLHFLDGSTTVSSVVATAAANTKVEHFQAGGSPSGRMTVVGTINMLKGDNPDRPFGCSVCQRF 484

  Fly   441 FPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELH 504
            |.::..||||.:.| |:.|:.|.:|...|.|..||.:|| ::||||:.:.|..|.:.|..|:.|.
  Fly   485 FSQQSTLVNHIKTHTGEKPYKCKICEVNFRQVATLNNHM-KIHTGEKPYNCSFCPKQFRQKSTLQ 548

  Fly   505 QHVR 508
            .|:|
  Fly   549 NHLR 552

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	32/139 (23%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		zf-H2C2_2	306..331	CDD:290200	12/24 (50%)
		C2H2 Zn finger	322..342	CDD:275368	6/19 (32%)
		C2H2 Zn finger	350..370	CDD:275368	7/19 (37%)
		zf-H2C2_2	362..385	CDD:290200	7/22 (32%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	10/24 (42%)
		C2H2 Zn finger	406..426	CDD:275368	8/67 (12%)
		SIR2	<425..>465	CDD:294129	16/102 (16%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	7/19 (37%)
		lambda-1	491..>603	CDD:212564	6/18 (33%)
		C2H2 Zn finger	575..595	CDD:275368
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
CG4360	NP_650879.1	C2H2 Zn finger	144..164	CDD:275368	3/20 (15%)
		zf-H2C2_2	157..181	CDD:290200	12/29 (41%)
		C2H2 Zn finger	172..192	CDD:275368	7/19 (37%)
		zf-H2C2_2	185..209	CDD:290200	12/23 (52%)
		C2H2 Zn finger	200..220	CDD:275368	6/19 (32%)
		C2H2 Zn finger	284..304	CDD:275368	7/19 (37%)
		zf-C2H2_8	287..363	CDD:292531	26/75 (35%)
		C2H2 Zn finger	312..332	CDD:275368	6/19 (32%)
		C2H2 Zn finger	340..360	CDD:275368	7/19 (37%)
		C2H2 Zn finger	478..498	CDD:275368	7/19 (37%)
		zf-H2C2_2	491..515	CDD:290200	10/23 (43%)
		C2H2 Zn finger	506..526	CDD:275368	8/20 (40%)
		zf-H2C2_2	519..543	CDD:290200	10/24 (42%)
		C2H2 Zn finger	534..554	CDD:275368	7/19 (37%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440484
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930