DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and znf143b

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_005159129.1	Gene:	znf143b / 393954	ZFINID:	ZDB-GENE-040426-1586	Length:	623	Species:	Danio rerio

Alignment Length:	679	Identity:	175/679 - (25%)
Similarity:	257/679 - (37%)	Gaps:	157/679 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   106 QQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHH--TLTNGSIVDAKTGQTV-LTAGSAAAKSH 167
            :.|...|.|...:|..:..|.....|..:.:.|..  :||...|::   ||.: |..||||...|
Zfish    31 EAVTVADDNIDGMDTVSLQAVTLVDGSTAYIQHSPKVSLTENKIME---GQVIQLEDGSAAYVQH 92

  Fly   168 --FSSIGALHLTQEECNEILIKRAIAAGHH----------------------------QTHTITA 202
              .|..|...|..|:...:.::....|..|                            |::||.|
Zfish    93 LPMSKTGGEGLRLEDGQAVQLEDGTTAYIHAPKETYDQGGLQAVQLEDGTTAYIQHMPQSNTILA 157

  Fly   203 ADGSHHHASGGTPSFCSVGG---ATTLLGDILPGISVQVQ--KVIQGLEDNEDSQGEAPNLKLEP 262
            ..      :.||.:.....|   |.|:  .:|...|.:::  :...||....||.|....:.|:
Zfish   158 IQ------ADGTVADLQTEGTIDAETI--SVLEQYSTKMEATECGTGLIGRGDSDGVHMQIVLQ- 213

  Fly   263 GTLELSPKTELQESMHFSETDATIKKERPYSCDE--CGKSFLLKHHLTTHARVHTGERPHICTH- 324
            |....||:.:     |..        |:.:.|:.  |||.:...|||..|.|.|||::|:||.|
Zfish   214 GQDCRSPRIQ-----HVG--------EKAFRCEHEGCGKLYTTAHHLKVHERSHTGDKPYICDHL 265

  Fly   325 -CGKSFAHKHCLNTHLLLHSTERPYQCQE--CKKSFTLKHHLLTHSRVHSRERPFVC--QECGRA 384
             |||.||..:.|.:|:..|:.|:||:|||  |.|||.....|..|:|.|:.|:||.|  :.|||:
Zfish   266 GCGKKFATGYGLKSHVRTHTGEKPYRCQELNCLKSFKTSGDLQKHTRTHTGEKPFKCPFEGCGRS 330

  Fly   385 FPLKRHLVTHSKFHAGERPYVCEE--CGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQL 447
            |........|.:.|.|||||.|.|  ||.:||...:...|.|.|....|:||...|
Zfish   331 FTTSNIRKVHIRTHTGERPYYCAEPNCGRAFASATNYKNHMRIHTGEKPYVCTVPG--------- 386

  Fly   448 VNHGRIHGKIPHSCTVCGKEFLQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHN 512
                            |.|.|.:..:|..| ..|||..:.:.|..||:.:...:.|..|.|||||
Zfish   387 ----------------CDKRFTEYSSLYKH-HVVHTPCKPYNCNHCGKTYKQISTLAMHKRTAHN 434

  Fly   513 GVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRE 577
            ...|               ....|.|....|  ...:.:||  .:.|.|..|.:..:.     :.
Zfish   435 DTEP---------------IEEEQEGYFEPP--AEAIDDPG--LMYTPSVVDDDSGSE-----QV 475

  Fly   578 CGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPV 642
            .||....:..:||..:..|.......|:.|:...:      |.....||.:|.        |...
Zfish   476 SGSEIMGQHHVALISQDGTQQVLSQADMQAMGGTI------TMVTQEGTTITI--------PAHE 526

  Fly   643 QIISSTGQVMSQTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVV 707
            .::||.|  ....|:|.|..:....|:||              ..:|..|.::.:..|.|:||.|
Zfish   527 AMLSSGG--AHSVTMVSADGTEGQVAIVT--------------PDLAAYQTEEGELIQDQEQHEV 575

  Fly   708 SVAPANKPKSHFCASCGKGFAAKHGLMQH 736
            |.:|  .|.:....|.|...|.:  |..|
Zfish   576 STSP--HPVTLLATSNGTHIAVQ--LSDH 600

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	38/89 (43%)
		C2H2 Zn finger	294..314	CDD:275368	9/21 (43%)
		zf-H2C2_2	306..331	CDD:290200	15/26 (58%)
		C2H2 Zn finger	322..342	CDD:275368	9/21 (43%)
		C2H2 Zn finger	350..370	CDD:275368	10/21 (48%)
		zf-H2C2_2	362..385	CDD:290200	11/24 (46%)
		C2H2 Zn finger	378..398	CDD:275368	6/21 (29%)
		zf-H2C2_2	390..415	CDD:290200	12/26 (46%)
		C2H2 Zn finger	406..426	CDD:275368	8/21 (38%)
		SIR2	<425..>465	CDD:294129	5/39 (13%)
		C2H2 Zn finger	434..454	CDD:275368	2/19 (11%)
		C2H2 Zn finger	461..482	CDD:275368	5/20 (25%)
		C2H2 Zn finger	490..509	CDD:275368	5/18 (28%)
		lambda-1	491..>603	CDD:212564	23/111 (21%)
		C2H2 Zn finger	575..595	CDD:275368	4/19 (21%)
		C2H2 Zn finger	720..740	CDD:275368	5/17 (29%)
		C2H2 Zn finger	752..771	CDD:275368
znf143b	XP_005159129.1	C2H2 Zn finger	232..254	CDD:275368	9/21 (43%)
		zf-H2C2_2	246..273	CDD:290200	15/26 (58%)
		zf-C2H2_8	262..341	CDD:292531	32/78 (41%)
		C2H2 Zn finger	262..284	CDD:275368	9/21 (43%)
		zf-H2C2_2	277..303	CDD:290200	13/25 (52%)
		C2H2 Zn finger	292..314	CDD:275368	10/21 (48%)
		zf-H2C2_2	306..333	CDD:290200	12/26 (46%)
		zf-C2H2_8	322..402	CDD:292531	30/105 (29%)
		C2H2 Zn finger	322..344	CDD:275368	6/21 (29%)
		zf-H2C2_2	338..363	CDD:290200	12/24 (50%)
		C2H2 Zn finger	352..374	CDD:275368	8/21 (38%)
		zf-H2C2_2	366..392	CDD:290200	9/50 (18%)
		C2H2 Zn finger	382..404	CDD:275368	7/47 (15%)
		C2H2 Zn finger	412..431	CDD:275368	5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	0	0.000