DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and D19B

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_477297.1	Gene:	D19B / 38717	FlyBaseID:	FBgn0022699	Length:	774	Species:	Drosophila melanogaster

Alignment Length:	654	Identity:	143/654 - (21%)
Similarity:	220/654 - (33%)	Gaps:	216/654 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   248 NEDSQGEAPNLKLEPGTLELSPKTE---------------LQESMHFSETDATIKKERPYSC--D 295
            ::||.|   |.|.:|....: |.||               .::::.:.|.........|:.|  :
  Fly   226 SDDSDG---NPKDKPKRKRI-PATERDRHRLIDCHICHQKFKKAIRYEEHMKHHNDLLPFQCTVE 286

  Fly   296 ECGKSFLLKHHLTTHA-RVHT-GERPHICTH--CGKSFAHKHCLNTHL-LLHSTERP---YQCQE 352
            .|.|.|...:.|..|. ..|| ....|.||:  |.||||....|:.|: .:|..:.|   :.|.|
  Fly   287 SCRKGFTTANGLRVHVEHAHTETSAMHPCTYEGCNKSFARPVLLSFHMKRVHKVDTPQRDFPCTE 351

  Fly   353 CKKSF----TLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEEC--GE 411
            |:|.|    .||.|:..|:   ..|.||.|:.||:.||:...|..|...|||.:.:||..|  |:
  Fly   352 CEKVFRCPTALKKHMYKHT---GEELPFACEICGKRFPINSVLRDHLLRHAGIKNHVCPYCGVGK 413

  Fly   412 SFAQE--NHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGR-IHGK-IPHSCTVCGKEFLQKR 472
            :..||  .|::.|::    ...:.|.:|..:...|..|.||.: :|.| ...:|..|||.|.:..
  Fly   414 TTRQEWNKHILTHTK----EKKYECRQCDHASHNKQALANHVKVVHEKRKDFACQYCGKTFGKSH 474

  Fly   473 TLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATII------ANQQLQQ 531
            ....| .|.||||:...|..||:.||.:..|.:|::|......|.|.....:      .:..:.:
  Fly   475 ACKIH-ERSHTGEKCCECKICGKVFLFEKGLTKHLKTHEKRDLPKTQGTNALMGDGASGSSTIAK 538

  Fly   532 AHHHQAGQQTH---PQTITVVSNPGNSTLL-----TVSTTDANGVARPQFVCRECGSAFNSREAL 588
            ...|..|:...   .|....|:||..|..|     .|:.|...|    |.:|.:||..||....:
  Fly   539 PSPHLRGRVERVDIAQLAGTVANPIPSVNLPSWSPQVNFTKKEG----QHICPDCGKGFNHVSNM 599

  Fly   589 ALHLRLHTGDKSLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMS 653
            .||.::
  Fly   600 KLHYKV----------------------------------------------------------- 605

  Fly   654 QTTLVQAANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSH 718
                                    ||                                 .|.|..
  Fly   606 ------------------------VH---------------------------------QKVKDF 613

  Fly   719 FCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCE-CGKAFFQKNHLMLHQRQH----------- 771
            .|..|.|.||.|..|..|...|..    .:.:.|: |||.|.|:..|..|.:.|
  Fly   614 CCRFCPKRFAKKQYLRHHEYIHTG----EKPYECKVCGKHFRQEQVLKTHMKVHDKPPRPPGKPK 674

  Fly   772 ------LETKPAISQQQEAATQQQLATAGEQQQVQVQIMPDGQIHGKVIKYEICRNVMPEDQQQE 830
                  .|:..|:.:||....:|....|.|:.....::          :.|:|..|   |.:::.
  Fly   675 EPAGPKAESSTAVKRQQPKNFEQYQDPAAERAAATAEL----------LAYQIEEN---EAKRKA 726

  Fly   831 QADM 834
            :|::
  Fly   727 EAEL 730

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	30/97 (31%)
		C2H2 Zn finger	294..314	CDD:275368	6/22 (27%)
		zf-H2C2_2	306..331	CDD:290200	11/28 (39%)
		C2H2 Zn finger	322..342	CDD:275368	9/22 (41%)
		C2H2 Zn finger	350..370	CDD:275368	9/23 (39%)
		zf-H2C2_2	362..385	CDD:290200	8/22 (36%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	9/26 (35%)
		C2H2 Zn finger	406..426	CDD:275368	7/23 (30%)
		SIR2	<425..>465	CDD:294129	9/41 (22%)
		C2H2 Zn finger	434..454	CDD:275368	6/20 (30%)
		C2H2 Zn finger	461..482	CDD:275368	7/20 (35%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	28/125 (22%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	720..740	CDD:275368	8/19 (42%)
		C2H2 Zn finger	752..771	CDD:275368	8/19 (42%)
D19B	NP_477297.1	zf-AD	12..83	CDD:214871
		C2H2 Zn finger	255..275	CDD:275368	1/19 (5%)
		C2H2 Zn finger	283..335	CDD:275368	18/51 (35%)
		C2H2 Zn finger	318..338	CDD:275368	7/19 (37%)
		COG5048	<347..512	CDD:227381	57/172 (33%)
		C2H2 Zn finger	349..369	CDD:275368	8/19 (42%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		C2H2 Zn finger	434..455	CDD:275368	6/20 (30%)
		C2H2 Zn finger	463..483	CDD:275368	7/20 (35%)
		C2H2 Zn finger	491..511	CDD:275368	7/19 (37%)
		C2H2 Zn finger	586..607	CDD:275368	7/103 (7%)
		C2H2 Zn finger	615..635	CDD:275368	8/19 (42%)
		zf-H2C2_2	627..652	CDD:290200	8/28 (29%)
		C2H2 Zn finger	643..663	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100