DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and CG10274

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001097525.1	Gene:	CG10274 / 38716	FlyBaseID:	FBgn0035690	Length:	863	Species:	Drosophila melanogaster

Alignment Length:	720	Identity:	152/720 - (21%)
Similarity:	229/720 - (31%)	Gaps:	266/720 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 AAESVLEISPNINYTVSGESMPYLLSTDGS----LAVQ-KDVKGLTAGGKNNVVRRMFVVNDPSF 82
            ||||..|...:|:..|..|..    |:||.    ||.: :|...:....|..|::.    .|..|
  Fly   181 AAESSEESEEDIDQDVDFEPN----SSDGDDDVPLAQRLRDNSRMIPKAKAAVIKE----EDQEF 237

  Fly    83 PPGTQRVITAGGASTVVKKQDNNQQVLSLDKNYLLVDPATAAAAAAAAGGDSGLAHHHTLTNGSI 147
            |.|::.....|..|...:|:               :.|              |..|.|     .|
  Fly   238 PTGSEEEDEDGEKSKSRRKR---------------IPP--------------GERHLH-----RI 268

  Fly   148 VDAKTGQTVLTAGSAAAKSHFSSIGALHLTQEECNEILIKRAIAAGHHQTH-------------- 198
            :|.                        |:..::     .|:||....|..|
  Fly   269 IDC------------------------HICHQK-----FKKAIRYEEHMKHHNDLLPFQCKVETC 304

  Fly   199 --TITAADG-----SHHHASGGTPSFCSVGGATTLLGDILPGISVQV--QKVIQGLEDNEDSQGE 254
              ..|.|.|     .|.|........|:|.|.    |...|.|.:..  .|.:.|:     ::..
  Fly   305 RKGFTTAGGLRLHIDHAHTELSEVHSCNVDGC----GKTFPRIRLLTFHMKKMHGI-----TKAA 360

  Fly   255 APNLKLEPGTLELSPKTELQE--------SMHFSETDATIKKERPYSCDECGKSFLLKHHLTTHA 311
            ||....        |.||.::        ..|..:.|.   ||.|:.|:.|||.|::...|..|.
  Fly   361 APPRDY--------PCTECEKVFRCPMALKKHMYKHDG---KELPFPCNICGKRFVINSALKDHL 414

  Fly   312 RVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTHSR-VHSRERP 375
            ..|.|.:.::|.:||.....:...|||:|.|:.|:.::|..|:.:...|..|..|.: ||.:.:.
  Fly   415 MRHAGIKNYVCPYCGVGKTTRQEWNTHILTHTQEKKFKCHICEHASHNKQSLANHIKIVHEKIKN 479

  Fly   376 FVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFAQENHLIMHSRFHG------------- 427
            :.||.||:.|........|...|.||:...|:.||:.|.....|..|.:.|.
  Fly   480 YACQYCGKTFGKSHACKIHEMTHTGEKRCECKVCGKKFLYPKSLTKHLKTHEKRVLRAIETYRQR 544

  Fly   428 -----------------------SLNPF-----------VCAECGASF---PRKFQLVNHGRI-- 453
                                   |:.|.           ||||..|:.   ||:.|.|:..::
  Fly   545 QVEMGETPGEQFDNPPAPPVEGISIEPIMSRNAADELLKVCAESVATIPKDPRRVQRVDLAQLAG 609

  Fly   454 --------------------------------------------HGKIPH------SCTVCGKEF 468
                                                        |.||.|      :|..|.|.|
  Fly   610 TAVNPIPSVSVPSWSPQVNFTKKEGKHICPGCGQGFNNIGNMKRHYKIIHEKVKDFACRFCPKRF 674

  Fly   469 LQKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQL--QQ 531
            .:.:|| .|...:||||:...|.:||..|..:..|.:|.|| |....|..|.....|.::|  |:
  Fly   675 AKAQTL-RHHEWIHTGEKPFECKTCGTHFRQETALKRHQRT-HENRPPVISPKFYAAREELEEQE 737

  Fly   532 AHHHQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHT 596
            ....:|.:|                      .||..        ||...|  ::|.|:...:|.:
  Fly   738 RSKREAKRQ----------------------ADAKR--------REIAEA--AKEQLSSLHKLES 770

  Fly   597 GDKSL 601
            .|:||
  Fly   771 SDRSL 775

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	27/84 (32%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		zf-H2C2_2	306..331	CDD:290200	7/24 (29%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	5/20 (25%)
		zf-H2C2_2	362..385	CDD:290200	8/23 (35%)
		C2H2 Zn finger	378..398	CDD:275368	6/19 (32%)
		zf-H2C2_2	390..415	CDD:290200	8/24 (33%)
		C2H2 Zn finger	406..426	CDD:275368	6/19 (32%)
		SIR2	<425..>465	CDD:294129	17/141 (12%)
		C2H2 Zn finger	434..454	CDD:275368	8/68 (12%)
		C2H2 Zn finger	461..482	CDD:275368	7/20 (35%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	26/113 (23%)
		C2H2 Zn finger	575..595	CDD:275368	5/19 (26%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
CG10274	NP_001097525.1	zf-AD	15..90	CDD:214871
		C2H2 Zn finger	334..353	CDD:275368	5/22 (23%)
		C2H2 Zn finger	368..388	CDD:275368	3/19 (16%)
		COG5048	394..729	CDD:227381	79/336 (24%)
		C2H2 Zn finger	397..417	CDD:275368	7/19 (37%)
		C2H2 Zn finger	425..445	CDD:275368	7/19 (37%)
		C2H2 Zn finger	453..474	CDD:275368	5/20 (25%)
		C2H2 Zn finger	482..502	CDD:275368	6/19 (32%)
		C2H2 Zn finger	510..530	CDD:275368	6/19 (32%)
		C2H2 Zn finger	638..659	CDD:275368	3/20 (15%)
		C2H2 Zn finger	667..687	CDD:275368	7/20 (35%)
		zf-H2C2_2	680..704	CDD:290200	10/24 (42%)
		C2H2 Zn finger	695..715	CDD:275368	8/20 (40%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	1.100