DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment cg and Zfat

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_006521187.2	Gene:	Zfat / 380993	MGIID:	2681865	Length:	1282	Species:	Mus musculus

Alignment Length:	875	Identity:	175/875 - (20%)
Similarity:	273/875 - (31%)	Gaps:	324/875 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 QEECNEILIKRAIAAGHHQTHTITAADGSHHHASGGTPSFCSVGGATTLLGDILPGISVQVQKVI 242
            :|:..|...||..|....:...|:..:..  ..||......||   .....:.:||.:    |:|
Mouse   207 KEDDREKASKRPRAQKTEKVQKISGKEAG--QLSGAKKPIISV---VLTAHEAIPGAT----KII 262

  Fly   243 QGLEDNEDSQGEAPNLKLEPGTLELSPKTELQE-SMHFSETDATIKKER--P-----YSCDECGK 299
            . :|......|..|.   |....:|.|:...|| ::..:..:..:|..|  |     ::|:.|.|
Mouse   263 P-VEAGPPETGAPPP---ETTAADLVPRRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNK 323

  Fly   300 SFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLL 364
            .|..||.|..|.|:||.|:|:.|:.|..:.|.|..||.||..|:.|: :.|..|..:...|.||.
Mouse   324 VFKFKHSLQAHLRIHTNEKPYKCSQCSYASAIKANLNVHLRKHTGEK-FACDYCSFTCLSKGHLK 387

  Fly   365 TH-SRVHSRERPFVCQECGRAFPLKRHLVTHSK-FH-------------------AGERP--YVC 406
            .| .|||.:.:.. |:.|.:.:...::|:.|.: .|                   .|:|.  |.|
Mouse   388 VHIERVHKKIKQH-CRFCKKKYSDVKNLIKHIRDMHDPQDKKVKEALDELRLMTREGKRQLLYDC 451

  Fly   407 EECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKIPHSCTVCGKEFLQK 471
            ..|...|..|.....|...||...||.|..||....:...|..|.|.|..: :.|.:|.|:|:..
Mouse   452 HICERKFKNELDRDRHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFV-YVCALCLKKFVSS 515

  Fly   472 RTLVSHMRRVH------------------------------TGEQ-------------------- 486
            ..|.||:|.||                              .|:|
Mouse   516 IRLRSHIREVHGAAQETLVFTSSINQSFCLLEPGGDIQQEALGDQLQLAAEEFVCPEIDVRKEEA 580

  Fly   487 -------------------AH------------------PC------VS--------CGEGFLTK 500
                               ||                  ||      ||        ..:.||.|
Mouse   581 CPGEAQPEVGLRELVVPGDAHAPPPGPLATPQSESSSLSPCKLETTVVSSDLNSLGVVSDDFLLK 645

  Fly   501 AELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVV------------SNPG 553
            ::               ||||...|..:......|:...||..:.:|::            |:||
Mouse   646 SD---------------TSSAEPPAAAEATSDTQHRDSAQTQGEEVTLLLAKAKSAGPDPESSPG 695

  Fly   554 --------------NSTLLTVSTTDAN------------GVARP--------------------- 571
                          :||.|..:.|:|:            ||.:|
Mouse   696 GRQKVGALPASESDSSTCLRANPTEASDLLPTVTDGGDLGVCQPDSCTPSSEHHPGSTAFMKVLD 760

  Fly   572 --------------------QFVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHF 616
                                ...|..||..|..:....:|:|.||.:.......|        |:
Mouse   761 SLQKKQMNTSLCERIRKVYGDLECEYCGKLFWYQVHFDMHVRTHTREHLYYCSQC--------HY 817

  Fly   617 LS-TASLNPGTVVTANPNLVGQSPV------------------------------PVQIISSTGQ 650
            .| |.:.....|:..:.|::.:.|.                              ||     ..:
Mouse   818 SSITKNCLKRHVIQKHSNILLKCPTDGCDYSTPDKYKLQAHLKVHTELDKRSYSCPV-----CEK 877

  Fly   651 VMSQTTLVQA-ANSTHPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQ--------QQQQQQQQQHV 706
            ..|:..|::: ..:.||:..:..:  ..|.|::..|:.:..::..:        .:.....|:|:
Mouse   878 SFSEDRLIKSHIKTNHPEVSMNTI--SEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHI 940

  Fly   707 ---VSVAP--------ANKPKS--------------HFCASCGKGFAAKHGLMQHNRRHPNGGCT 746
               ..|.|        |.:.||              |.|..|||.|.:|..|..|...|.:.|..
Mouse   941 WAHEGVKPFKCSLCEYATRSKSNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTSDGKQ 1005

  Fly   747 VRTHVCECGKAFFQKNHLMLHQRQHLETKP 776
            .:..||:...|  ||..|:.|..||...||
Mouse  1006 FKCTVCDYTAA--QKPQLLRHMEQHASFKP 1033

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	34/91 (37%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	9/24 (38%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	7/20 (35%)
		zf-H2C2_2	362..385	CDD:290200	8/23 (35%)
		C2H2 Zn finger	378..398	CDD:275368	4/20 (20%)
		zf-H2C2_2	390..415	CDD:290200	9/46 (20%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		SIR2	<425..>465	CDD:294129	12/39 (31%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	6/32 (19%)
		lambda-1	491..>603	CDD:212564	33/198 (17%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368	8/19 (42%)
		C2H2 Zn finger	752..771	CDD:275368	6/18 (33%)
Zfat	XP_006521187.2	zf-C2H2	316..338	CDD:333835	9/21 (43%)
		C2H2 Zn finger	318..338	CDD:275368	9/19 (47%)
		zf-H2C2_5	344..368	CDD:372805	9/23 (39%)
		C2H2 Zn finger	346..366	CDD:275368	8/19 (42%)
		C2H2 Zn finger	373..394	CDD:275368	7/20 (35%)
		C2H2 Zn finger	401..441	CDD:275368	5/39 (13%)
		C2H2 Zn finger	451..471	CDD:275368	5/19 (26%)
		C2H2 Zn finger	479..499	CDD:275368	6/19 (32%)
		C2H2 Zn finger	505..523	CDD:275368	7/17 (41%)
		C2H2 Zn finger	784..804	CDD:275368	6/19 (32%)
		C2H2 Zn finger	812..862	CDD:275368	7/57 (12%)
		C2H2 Zn finger	872..891	CDD:275368	4/23 (17%)
		C2H2 Zn finger	922..943	CDD:275368	2/20 (10%)
		C2H2 Zn finger	951..971	CDD:275368	3/19 (16%)
		C2H2 Zn finger	979..999	CDD:275368	8/19 (42%)
		zf-H2C2_5	1006..1028	CDD:372805	7/23 (30%)
		C2H2 Zn finger	1008..1028	CDD:275368	7/21 (33%)
		C2H2 Zn finger	1036..1057	CDD:275368
		C2H2 Zn finger	1083..1101	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100