Protein Alignment cg and Zfp251

DIOPT Version :10

• Sequence 1: NP_001097306.2
• Gene: cg / 36571
• FlyBaseID: FBgn0000289
• Length: 837
• Species: Drosophila melanogaster
• Sequence 2: NP_001178840.1
• Gene: Zfp251 / 366954
• RGDID: 1311138
• Length: 633
• Species: Rattus norvegicus
• Alignment Length: 576
• Identity: 151/576 - (26%)
• Similarity: 210/576 - (36%)
• Gaps: 202/576 - (35%)

  Fly   280 SETDATIKK----ERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLL 340
            |::..||::    :|.:.||.|.|.|.....|:.|.|.||||:|:.|..||::|.|...|..|..
  Rat   186 SQSGVTIQRNKTGQRIFKCDICNKMFKYNSDLSRHRRSHTGEKPYECGPCGRAFTHSSNLILHQR 250

  Fly   341 LHSTERPYQCQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYV 405
            :|:..:|::|.||.|:|.|..:|..|.|:|:.|:||.|.|||:||.....|:.|...|.||:||.
  Rat   251 IHTGNKPFKCDECGKTFGLNSYLRLHQRIHTGEKPFGCNECGKAFSRSSSLIQHRIIHTGEKPYK 315

  Fly   406 CEECGESFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFL 469
            |.|||::|:|...|..|.|.|....|..|:.||.:|.|...|:.|.||| |:.||.||.|||.|.
  Rat   316 CNECGKAFSQSPQLTQHQRIHTGEKPHGCSWCGKAFSRNASLIQHQRIHTGEKPHKCTQCGKAFS 380

  Fly   470 QKRTLVSHMRRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHH 534
            |..:|..| .||||||:.:.|..||..|...:.|.:||| .|.|..|
  Rat   381 QSSSLFLH-HRVHTGEKPYVCGECGRAFGFNSHLTEHVR-IHTGEKP------------------ 425

  Fly   535 HQAGQQTHPQTITVVSNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDK 599
                                                  :||.|||.||:....|..|.|:|||:|
  Rat   426 --------------------------------------YVCGECGKAFSRSSTLMQHRRVHTGEK 452

  Fly   600 SLMTDLCALTAALPGHFLSTASLNPGTVVTANPNLVGQSPVPVQIISSTGQVMSQTTLVQAANST 664
            ......|.                                               ...:|::..|
  Rat   453 PYQCAECG-----------------------------------------------KAFIQSSQLT 470

  Fly   665 HPQAVVTAVPTMPVHGQQQHLQHVAQQQQQQQQQQQQQQQHVVSVAPANKPKSHFCASCGKGFAA 729
            ..|.|.|.                                          .|.:.|..|||.|:.
  Rat   471 LHQRVHTG------------------------------------------EKPYECGLCGKAFSR 493

  Fly   730 KHGLMQHNRRH--------------------------PNGGC-----------TVRTHV----C- 752
            :..|.||.|.|                          .:||.           |:|:..    |
  Rat   494 RSALTQHRRVHMGESPQEFECGPDFVYDSSSHLSAGERHGGTFSHSAKLVLQWTIRSEEKPRGCR 558

  Fly   753 ECGKAFFQKNHLMLHQRQHLETKPAISQQ--------QEAATQQQLATAGEQQQVQ 800
            ||||.:...:..:.:||.....||:..|:        ....|...:...||:.|::
  Rat   559 ECGKTYSSSSQSVDYQRIQAGEKPSTCQECGGKAGSGVSPLTPHHVTRVGEKPQLK 614

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	32/87 (37%)
		C2H2 Zn finger	294..314	CDD:275368	8/19 (42%)
		zf-H2C2_2	306..331	CDD:463886	12/24 (50%)
		C2H2 Zn finger	322..342	CDD:275368	7/19 (37%)
		C2H2 Zn finger	350..370	CDD:275368	9/19 (47%)
		C2H2 Zn finger	378..398	CDD:275368	8/19 (42%)
		C2H2 Zn finger	406..426	CDD:275368	9/19 (47%)
		C2H2 Zn finger	434..454	CDD:275368	8/19 (42%)
		C2H2 Zn finger	461..482	CDD:275368	10/20 (50%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		C2H2 Zn finger	575..595	CDD:275368	9/19 (47%)
		C2H2 Zn finger	720..740	CDD:275368	9/19 (47%)
		C2H2 Zn finger	752..771	CDD:275368	7/19 (37%)
Zfp251	NP_001178840.1	KRAB	15..75	CDD:214630
		COG5048	82..467	CDD:227381	118/385 (31%)
		C2H2 Zn finger	204..224	CDD:275368	8/19 (42%)
		C2H2 Zn finger	232..252	CDD:275368	7/19 (37%)
		C2H2 Zn finger	260..280	CDD:275368	9/19 (47%)
		C2H2 Zn finger	288..308	CDD:275368	8/19 (42%)
		C2H2 Zn finger	316..336	CDD:275368	9/19 (47%)
		C2H2 Zn finger	344..364	CDD:275368	8/19 (42%)
		C2H2 Zn finger	372..392	CDD:275368	10/20 (50%)
		C2H2 Zn finger	400..420	CDD:275368	8/20 (40%)
		C2H2 Zn finger	428..448	CDD:275368	9/19 (47%)
		C2H2 Zn finger	456..476	CDD:275368	4/66 (6%)
		zf-H2C2_2	469..493	CDD:463886	10/65 (15%)
		C2H2 Zn finger	484..504	CDD:275368	9/19 (47%)
		C2H2 Zn finger	557..577	CDD:275368	7/19 (37%)
		C2H2 Zn finger	585..602	CDD:275368	2/16 (13%)