DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and Zfat

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_006241775.1	Gene:	Zfat / 362925	RGDID:	1310886	Length:	1235	Species:	Rattus norvegicus

Alignment Length:	1049	Identity:	206/1049 - (19%)
Similarity:	321/1049 - (30%)	Gaps:	360/1049 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 RAAESVL--------EISPNINYTVSGESMPYLLSTDGSLAVQKDVKGLTAGGKNNVVRRMFVVN 78
            ||||:..        ..|||     ..|.:.::....|...|..|          :|:..:..:|
  Rat     4 RAAENTAIFMCKCCNLFSPN-----QSELVTHVSEKHGEEGVNVD----------DVIIPLRPLN 53

  Fly    79 DPSFPPGTQRVITAGGASTVV------------KKQDNNQQVLSLDKNYLLVDPATAAAAAAAAG 131
            .|..|..::     ||...:|            ||....::|:   :|  ||.|......|...|
  Rat    54 TPENPNPSK-----GGDEFLVMKRKRGRPKGSTKKPSTEEEVV---EN--LVSPIEDGPLAPEEG 108

  Fly   132 GDSGLAHHHTLTNGSIVDAK-------TGQ-------TVLTAGSAAAKSHFSSIGALHLTQEECN 182
            .        .|...|:..:|       |.|       .||..|......:.|.:......:|:..
  Rat   109 S--------RLAPSSLECSKCCRKFSNTRQLRKHICIIVLNLGEEGDAGNESDLDLEKTYKEDDR 165

  Fly   183 EILIKRAIAAGHHQTHTITAADGSHHHASGGTPSFCSVGGATTLLGDILPGISVQVQKVIQGLED 247
            |...||..|....:...|:..:..  ..||......||   .....:.:||.:    |:|. :|.
  Rat   166 EKTSKRPRAQKTEKVQKISGKEAG--QLSGAKKPIISV---VLTAHEAIPGAT----KIIP-VEA 220

  Fly   248 NEDSQGEAPNLKLEPGTLELSPKTELQE-SMHFSETDATIKKER--P-----YSCDECGKSFLLK 304
            .....|..|.   |....:|.|:...|| ::..:..:..:|..|  |     ::|:.|.|.|..|
  Rat   221 GPPETGAPPP---ETTAADLVPRRGYQEYAIQQTPYEQPMKSSRLGPTQLKIFTCEYCNKVFKFK 282

  Fly   305 HHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQCQECKKSFTLKHHLLTH-SR 368
            |.|..|.|:||.|:|:.|:.|..:.|.|..||.||..|:.|: :.|..|..:...|.||..| .|
  Rat   283 HSLQAHLRIHTNEKPYKCSQCSYASAIKANLNVHLRKHTGEK-FACDYCSFTCLSKGHLKVHIER 346

  Fly   369 VHSRERPFVCQECGRAFPLKRHLVTHSK-FH-------------------AGERP--YVCEECGE 411
            ||.:.:.. |:.|.:.:...::|:.|.: .|                   .|:|.  |.|..|..
  Rat   347 VHKKIKQH-CRFCKKKYSDVKNLIKHIRDMHDPQDKKVKEALDELRLMTREGKRQLLYDCHICER 410

  Fly   412 SFAQENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIHGKIPHSCTVCGKEFLQKRTLVS 476
            .|..|.....|...||...||.|..||....:...|..|.|.|..: :.|.:|.|:|:....|.|
  Rat   411 KFKNELDRDRHMLVHGDKWPFACELCGHGATKYQALELHVRKHPFV-YVCAICLKKFVSSIRLRS 474

  Fly   477 HMRRVHTGEQ--------------------------------------AHPCVSCGEGFLTKAEL 503
            |:|.||...|                                      ..|.:...:|.:...|.
  Rat   475 HIREVHGAAQETLVFTSSINQSFCLLEPGGDIQQEALGNQLPLAAEEFVCPEIDVRKGEVCPGEA 539

  Fly   504 HQHV----------------------------------RTAHNG-------------VNPNTSSA 521
            ...|                                  .|..|.             :..:||||
  Rat   540 QPEVGLRELEAPGEACAPAVPLANPQSVSVSLSPCKLETTVVNSDLNSLGVVSDDFLLKTDTSSA 604

  Fly   522 TIIANQQLQQAHHHQAGQQTHPQTITVVSNPGNST---------------LLTVSTTDAN----- 566
            ...|..:|.....|:...||..:.:|::.....||               .|..|.:|:|
  Rat   605 EPHAAAELTSDTQHRGSAQTQGEEVTLLLAKAKSTGPDSESPPSGGQNVGALPASESDSNRCLRA 669

  Fly   567 ------------------GVARP-----------------------------------------Q 572
                              ||.:|                                         .
  Rat   670 NPAETSDLLPTVADGGDLGVCQPDSCTSSSEHHPGSTAFMKVLDSLQKKQMNTSLCERIRKVYGD 734

  Fly   573 FVCRECGSAFNSREALALHLRLHTGDKSLMTDLCALTAALPGHFLS-TASLNPGTVVTANPNLVG 636
            ..|..||..|..:....:|:|.||.:.......|        |:.| |.:.....|:..:.|::.
  Rat   735 LECEYCGKLFWYQVHFDMHVRTHTREHLYYCSQC--------HYSSITKNCLKRHVIQKHSNILL 791

  Fly   637 QSPV------------------------------PVQIISSTGQVMSQTTLVQA-ANSTHPQAVV 670
            :.|.                              ||     ..:..|:..|::: ..:.||:..:
  Rat   792 KCPTDGCDYSTPDKYKLQAHLKVHTELDKRSYSCPV-----CEKSFSEDRLIKSHIKTNHPEVSM 851

  Fly   671 TAVPTMPVHGQQQHLQHVAQQQQQQ--------QQQQQQQQQHV---VSVAP--------ANKPK 716
            ..:  ..|.|::..|:.:..::..:        .:.....|:|:   ..|.|        |.:.|
  Rat   852 NTI--SEVLGRRVQLKGLIGKRAMKCPYCDFYFMKNGSDLQRHIWAHEGVKPFKCSLCEYATRSK 914

  Fly   717 S--------------HFCASCGKGFAAKHGLMQHNRRHPNGGCTVRTHVCECGKAFFQKNHLMLH 767
            |              |.|..|||.|.:|..|..|...|.:.|...:..||:...|  ||..|:.|
  Rat   915 SNLKAHMNRHSTEKTHLCDMCGKKFKSKGTLKSHKLLHTSDGKQFKCTVCDYTAA--QKPQLLRH 977

  Fly   768 QRQHLETKP 776
            ..||...||
  Rat   978 MEQHASFKP 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	34/91 (37%)
		C2H2 Zn finger	294..314	CDD:275368	9/19 (47%)
		zf-H2C2_2	306..331	CDD:290200	9/24 (38%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	7/20 (35%)
		zf-H2C2_2	362..385	CDD:290200	8/23 (35%)
		C2H2 Zn finger	378..398	CDD:275368	4/20 (20%)
		zf-H2C2_2	390..415	CDD:290200	9/46 (20%)
		C2H2 Zn finger	406..426	CDD:275368	5/19 (26%)
		SIR2	<425..>465	CDD:294129	12/39 (31%)
		C2H2 Zn finger	434..454	CDD:275368	6/19 (32%)
		C2H2 Zn finger	461..482	CDD:275368	8/20 (40%)
		C2H2 Zn finger	490..509	CDD:275368	3/52 (6%)
		lambda-1	491..>603	CDD:212564	32/237 (14%)
		C2H2 Zn finger	575..595	CDD:275368	6/19 (32%)
		C2H2 Zn finger	720..740	CDD:275368	8/19 (42%)
		C2H2 Zn finger	752..771	CDD:275368	6/18 (33%)
Zfat	XP_006241775.1	C2H2 Zn finger	272..292	CDD:275368	9/19 (47%)
		zf-H2C2_2	284..306	CDD:290200	9/21 (43%)
		C2H2 Zn finger	300..320	CDD:275368	8/19 (42%)
		C2H2 Zn finger	327..348	CDD:275368	7/20 (35%)
		C2H2 Zn finger	355..395	CDD:275368	5/39 (13%)
		C2H2 Zn finger	405..425	CDD:275368	5/19 (26%)
		C2H2 Zn finger	433..453	CDD:275368	6/19 (32%)
		C2H2 Zn finger	459..477	CDD:275368	7/17 (41%)
		C2H2 Zn finger	737..757	CDD:275368	6/19 (32%)
		C2H2 Zn finger	765..815	CDD:275368	7/57 (12%)
		C2H2 Zn finger	825..844	CDD:275368	4/23 (17%)
		C2H2 Zn finger	875..896	CDD:275368	2/20 (10%)
		C2H2 Zn finger	904..924	CDD:275368	3/19 (16%)
		zf-H2C2_2	916..941	CDD:290200	6/24 (25%)
		C2H2 Zn finger	932..952	CDD:275368	8/19 (42%)
		C2H2 Zn finger	961..981	CDD:275368	7/21 (33%)
		C2H2 Zn finger	989..1010	CDD:275368
		C2H2 Zn finger	1036..1054	CDD:275368
		zf-C2H2	270..292	CDD:278523	9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24388
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.100