DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and Zfp143

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	NP_001012169.2	Gene:	Zfp143 / 361627	RGDID:	1305662	Length:	638	Species:	Rattus norvegicus

Alignment Length:	707	Identity:	187/707 - (26%)
Similarity:	267/707 - (37%)	Gaps:	184/707 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    55 VQKDVKGLTAGGKNNVVRRMFVVNDPSFPPG---TQRVITAGGASTVVKKQDN--NQQVLSLDKN 114
            :.:|.:|:|                 .||.|   .|.|......:..|...||  |.:.:||.
  Rat     6 INRDSQGMT-----------------EFPGGGMEAQHVTLCLTEAVTVADGDNLENMEGVSLQ-- 51

  Fly   115 YLLVDPATAAAAAAAAGGDSGLAHHHTLTNGSIVDAKTGQTV-LTAGSAAAKSHF----SSIGAL 174
                       |...|.|.:....|:: .:|.::|   ||.: |..||||...|.    |:..:|
  Rat    52 -----------AVTLADGSTAYIQHNS-KDGRLID---GQVIQLEDGSAAYVQHVPIPKSTGDSL 101

  Fly   175 HLTQEECNEILIKRAIAAGHHQT----------HTITAADGSH---HHA-------------SGG 213
            .|  |:...:.::....|..|.|          ..:...||:.   |||             :.|
  Rat   102 RL--EDGQAVQLEDGTTAFIHHTSKDSYDQSSLQAVQLEDGTTAYIHHAVQVPQPDTILAIQADG 164

  Fly   214 TPSFCSVGGATTLLGDILPGISVQVQKV-IQGLED-------NEDSQGEAPNLKLEPGTLELSPK 270
            |.:....|.| |:..|.:..:.....|| |.|.|.       .|:.|.:...:.|:.....::||
  Rat   165 TVAGLHTGDA-TIDPDTISALEQYAAKVSIDGSEGVTSTGLIGENEQEKKMQIVLQGHATRVTPK 228

  Fly   271 TELQESMHFSETDATIKKERPYSC--DECGKSFLLKHHLTTHARVHTGERPHICTH--CGKSFAH 331
            :  |:|           .|:.:.|  |.|||.:...|||..|.|.|||:||:.|.|  |||:||.
  Rat   229 S--QQS-----------GEKAFRCKYDGCGKLYTTAHHLKVHERSHTGDRPYQCEHSGCGKAFAT 280

  Fly   332 KHCLNTHLLLHSTERPYQCQE--CKKSFTLKHHLLTHSRVHSRERPFVC--QECGRAFPLKRHLV 392
            .:.|.:|...|:.|:||:|.|  |.|||.....|..|.|.|:.||||.|  :.|||:|.......
  Rat   281 GYGLKSHFRTHTGEKPYRCSEDNCTKSFKTSGDLQKHIRTHTGERPFKCPIEGCGRSFTTSNIRK 345

  Fly   393 THSKFHAGERPYVCEE--CGESFAQENHLIMHSRFHGSLNPFVCA--ECGASFPRKFQLVNHGRI 453
            .|.:.|.|||||.|.|  ||.:||...:...|.|.|....|:||.  .|...|.....|..|..:
  Rat   346 VHIRTHTGERPYYCTEPGCGRAFASATNYKNHVRIHTGEKPYVCTVPGCDKRFTEYSSLYKHHVV 410

  Fly   454 H-GKIPHSCTVCGKEFLQKRTLVSHMRRVH---------------------------------TG 484
            | ...|::|..|||.:.|..||..|.|..|                                 ||
  Rat   411 HTHSKPYNCNHCGKTYKQISTLAMHKRTAHNDTEPIEEEQEAFFEPPPGQGDDVLKGSQITYVTG 475

  Fly   485 EQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHPQTITVV 549
            .:....||.....:|::.|.|.|              |:|:....|..:..||..|....|||:|
  Rat   476 VEGEDIVSTQVATVTQSGLSQQV--------------TLISQDGTQHVNISQADMQAIGNTITMV 526

  Fly   550 SNPGNSTLLTVSTTDANGVARPQFVCRECGSAFNSREALALHLRLHTGDKS---LMTDLCALTAA 611
            :..|  |.:||.|.||        |....|:     .::|:.....|..:.   :..||.|..||
  Rat   527 TQDG--TPITVPTHDA--------VISSAGT-----HSVAMVTAEGTEGQQVAIVAQDLAAFHAA 576

  Fly   612 LP-------GHFLSTASLNPGTVV-TANPNLV----GQSPVPVQIISSTGQVMSQTT 656
            ..       .|.|.|....|.|:| |:|...:    |:.|...:.|....::....|
  Rat   577 SSEMGHQPHSHHLVTTETRPLTLVATSNGTQIAVQLGEQPSLEEAIRIASRIQQGET 633

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	38/89 (43%)
		C2H2 Zn finger	294..314	CDD:275368	10/21 (48%)
		zf-H2C2_2	306..331	CDD:290200	15/26 (58%)
		C2H2 Zn finger	322..342	CDD:275368	9/21 (43%)
		C2H2 Zn finger	350..370	CDD:275368	9/21 (43%)
		zf-H2C2_2	362..385	CDD:290200	12/24 (50%)
		C2H2 Zn finger	378..398	CDD:275368	6/21 (29%)
		zf-H2C2_2	390..415	CDD:290200	12/26 (46%)
		C2H2 Zn finger	406..426	CDD:275368	8/21 (38%)
		SIR2	<425..>465	CDD:294129	11/42 (26%)
		C2H2 Zn finger	434..454	CDD:275368	5/21 (24%)
		C2H2 Zn finger	461..482	CDD:275368	9/20 (45%)
		C2H2 Zn finger	490..509	CDD:275368	6/18 (33%)
		lambda-1	491..>603	CDD:212564	27/114 (24%)
		C2H2 Zn finger	575..595	CDD:275368	2/19 (11%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
Zfp143	NP_001012169.2	SFP1	<207..292	CDD:227516	32/97 (33%)
		C2H2 Zn finger	239..261	CDD:275368	10/21 (48%)
		COG5048	<251..424	CDD:227381	69/172 (40%)
		C2H2 Zn finger	269..291	CDD:275368	9/21 (43%)
		C2H2 Zn finger	299..321	CDD:275368	9/21 (43%)
		C2H2 Zn finger	329..351	CDD:275368	6/21 (29%)
		C2H2 Zn finger	359..381	CDD:275368	8/21 (38%)
		C2H2 Zn finger	389..411	CDD:275368	5/21 (24%)
		C2H2 Zn finger	419..438	CDD:275368	8/18 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	0	0.000