DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment cg and Zfp786

DIOPT Version :9

Sequence 1:	NP_001097306.2	Gene:	cg / 36571	FlyBaseID:	FBgn0000289	Length:	837	Species:	Drosophila melanogaster
Sequence 2:	XP_030111337.1	Gene:	Zfp786 / 330301	MGIID:	3026883	Length:	881	Species:	Mus musculus

Alignment Length:	445	Identity:	140/445 - (31%)
Similarity:	190/445 - (42%)	Gaps:	90/445 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 ECNEILIKRAIAAGHHQTHT---------------ITAADGSHHHA-SGGTPSFCSVGGATTLLG 228
            |.....:.::..||..:|||               :......|.|. .|..|.||...|
Mouse   472 EYGNCFLSQSKQAGLCRTHTGEKASQCPESNKRLCLRGLQNVHQHGLRGEKPVFCRKCG------ 530

  Fly   229 DILPGISVQVQKVIQGLEDNEDSQGEAPNLKLEPGTLELSPKTEL---QESMHFSETDATIK--- 287
                                   ||...:..|...|..||.:...   |...:||:....::
Mouse   531 -----------------------QGFTKHCGLTEHTRILSGEKSFWCAQCGRNFSQKGQLLRHQR 572

  Fly   288 ---KERPYSCDECGKSFLLKHHLTTHARVHTGERPHICTHCGKSFAHKHCLNTHLLLHSTERPYQ 349
               :|:|:.|..|...|.||..|..|...|.||||..|:.||::|.|:..|..||.:||.|||:|
Mouse   573 LHLEEKPFQCTMCELRFHLKSRLRAHQLQHGGERPFSCSECGRAFTHQCKLREHLRVHSGERPFQ 637

  Fly   350 CQECKKSFTLKHHLLTHSRVHSRERPFVCQECGRAFPLKRHLVTHSKFHAGERPYVCEECGESFA 414
            |.||.|||.||..|..|.|:||:||||.|.|||:.|..:..|..|.:.|:||||:.|.||...|.
Mouse   638 CPECHKSFRLKGVLKAHQRIHSKERPFSCGECGKGFIRQSKLTEHFRVHSGERPFQCPECDRRFR 702

  Fly   415 QENHLIMHSRFHGSLNPFVCAECGASFPRKFQLVNHGRIH-GKIPHSCTVCGKEFLQKRTLVSHM 478
            .:..|:.|.|.|....||.|.|||.|:..|..:..|..:| |::|.||. |||.|.::..||.||
Mouse   703 LKGQLLSHQRLHTGERPFQCPECGKSYRVKADMKAHQLLHGGQMPFSCQ-CGKGFAKQSKLVEHM 766

  Fly   479 RRVHTGEQAHPCVSCGEGFLTKAELHQHVRTAHNGVNPNTSSATIIANQQLQQAHHHQAGQQTHP 543
             |.||||:...|..|.:.|..||:|..| :..|.|..|.....   .::..::..|....|:.|
Mouse   767 -RTHTGEKPFQCPKCDKSFRLKAQLLSH-QGLHTGERPFHCPE---CDKNFREKGHMLRHQRIH- 825

  Fly   544 QTITVVSNPGNSTLLTVSTTDANGVARPQ--FVCRECGSAFNSREALALHLRLHT 596
                                      ||:  |.|.:||..|..:..||.|:|:||
Mouse   826 --------------------------RPERPFACGDCGKGFIYKSKLAEHIRVHT 854

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
cg	NP_001097306.2	COG5048	287..>371	CDD:227381	39/89 (44%)
		C2H2 Zn finger	294..314	CDD:275368	7/19 (37%)
		zf-H2C2_2	306..331	CDD:290200	11/24 (46%)
		C2H2 Zn finger	322..342	CDD:275368	8/19 (42%)
		C2H2 Zn finger	350..370	CDD:275368	11/19 (58%)
		zf-H2C2_2	362..385	CDD:290200	13/22 (59%)
		C2H2 Zn finger	378..398	CDD:275368	7/19 (37%)
		zf-H2C2_2	390..415	CDD:290200	11/24 (46%)
		C2H2 Zn finger	406..426	CDD:275368	7/19 (37%)
		SIR2	<425..>465	CDD:294129	15/40 (38%)
		C2H2 Zn finger	434..454	CDD:275368	7/19 (37%)
		C2H2 Zn finger	461..482	CDD:275368	10/20 (50%)
		C2H2 Zn finger	490..509	CDD:275368	7/18 (39%)
		lambda-1	491..>603	CDD:212564	25/108 (23%)
		C2H2 Zn finger	575..595	CDD:275368	8/19 (42%)
		C2H2 Zn finger	720..740	CDD:275368
		C2H2 Zn finger	752..771	CDD:275368
Zfp786	XP_030111337.1	KRAB	113..171	CDD:214630
		COG5048	330..821	CDD:227381	125/383 (33%)
		C2H2 Zn finger	346..366	CDD:275370
		C2H2 Zn finger	374..391	CDD:275370
		C2H2 Zn finger	498..518	CDD:275368	2/19 (11%)
		C2H2 Zn finger	526..546	CDD:275368	6/48 (13%)
		C2H2 Zn finger	554..574	CDD:275368	3/19 (16%)
		C2H2 Zn finger	582..602	CDD:275368	7/19 (37%)
		C2H2 Zn finger	610..630	CDD:275368	8/19 (42%)
		C2H2 Zn finger	638..658	CDD:275368	11/19 (58%)
		C2H2 Zn finger	666..686	CDD:275368	7/19 (37%)
		C2H2 Zn finger	694..714	CDD:275368	7/19 (37%)
		C2H2 Zn finger	722..742	CDD:275368	7/19 (37%)
		C2H2 Zn finger	751..769	CDD:275368	9/19 (47%)
		C2H2 Zn finger	777..797	CDD:275368	7/20 (35%)
		C2H2 Zn finger	805..825	CDD:275368	2/22 (9%)
		C2H2 Zn finger	833..853	CDD:275368	8/19 (42%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	1	0.960